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Total 80126 results found since Jan 2013.
Mitophagy-dependent mitochondrial ROS mediates 2,5-hexanedione-induced NLRP3 inflammasome activation in BV2 microglia
In conclusion, our data indicated that HD triggered activation of NLRP3 inflammasome through mitophagy-dependent mtROS production, offering an important insight for the immunopathogenesis of environmental toxins-induced neuroinflammation and neurotoxicity.PMID:37722613 | DOI:10.1016/j.neuro.2023.09.008
Source: Neurotoxicology - September 18, 2023 Category: Neurology Authors: Wenqiong Wang Rui Chang Yan Wang Liyan Hou Qingshan Wang Source Type: research
Comparison of three DREADD agonists acting on Gq-DREADDs in the ventral tegmental area to alter locomotor activity in tyrosine hydroxylase:Cre male and female rats
CONCLUSIONS: Large individual variability was observed in both DREADD agonist behavioral effects and receptor expression. These results suggest further basic research would facilitate the utility of these chemogenetic tools for behavioral neuroscience research.PMID:37722510 | DOI:10.1016/j.bbr.2023.114674
Source: Behavioural Brain Research - September 18, 2023 Category: Neurology Authors: Hannah L Robinson Katherine L Nicholson Keith L Shelton Peter J Hamilton Matthew L Banks Source Type: research
Secondary surgical procedures following motor nerve injuries
CONCLUSIONS: Secondary surgical procedures are a valuable option for functional reconstruction after nerve injury.PMID:37721574 | DOI:10.1007/s00115-023-01543-y
Source: Der Nervenarzt - September 18, 2023 Category: Neurology Authors: Johannes Heinzel Cosima Prahm Henrik Lauer Adrien Daigeler Helene Hurth Martin Schuhmann Jonas Kolbenschlag Source Type: research
Subjective cognitive decline exhibits alterations of resting-state phase-amplitude coupling in precuneus
CONCLUSIONS: The SCD group demonstrated reduced theta-gamma PAC in the precuneus.SIGNIFICANCE: Subjective perception of cognitive decline is reflected by objective alterations of brain function.PMID:37722986 | DOI:10.1016/j.clinph.2023.08.015
Source: Clinical Neurophysiology - September 18, 2023 Category: Neurology Authors: Chia-Hsiung Cheng Chun-Che Hung Yi-Ping Chao Rui Nouchi Pei-Ning Wang Source Type: research
Resveratrol ameliorates diabetic encephalopathy through PDE4D/PKA/Drp1 signaling
This study illustrated the role of PDE4D in DE and investigated whether resveratrol protected against DE via inhibiting PDE4D. db/db male mice and hippocampus cell line (HT22) were used to investigate the role of PDE4D and the protective effect of resveratrol on cognitive function under high glucose (HG). PDE4D overexpression or knockdown lentivirus and PKA specific inhibitor H89 were used to further identify the indispensable role of PDE4D/PKA signaling pathway in resveratrol's amelioration effect of neurotoxicity. Resveratrol attenuated cognitive impairment in db/db mice, reduced PDE4D protein, restored the impaired mito...
Source: Brain Research Bulletin - September 18, 2023 Category: Neurology Authors: Yanjuan Cao Wen Sun Chang Liu Zihui Zhou Zongli Deng Mingjie Zhang Meng Yan Xiaoxing Yin Xia Zhu Source Type: research
Corrigendum to "Understanding the role of the hematopoietic niche in Huntington's disease's phenotypic expression: In vivo evidence using a parabiosis model" Neurobiol Dis. 2023 May;180:106091. doi:10.1016/j.nbd.2023.106091. Epub 2023 Mar 24
Neurobiol Dis. 2023 Sep 16:106289. doi: 10.1016/j.nbd.2023.106289. Online ahead of print.NO ABSTRACTPMID:37722998 | DOI:10.1016/j.nbd.2023.106289
Source: Neurobiology of Disease - September 18, 2023 Category: Neurology Authors: Marie Rieux Melanie Alpaugh Shireen Salem Alberto Siddu Martine Saint-Pierre H élèna L Denis Heike Rohweder Frank Herrmann Chantal Bazenet Steve Lacroix Francesca Cicchetti Source Type: research
The effects of sensorimotor and linguistic information on the basic-level advantage
Cognition. 2023 Sep 16;241:105606. doi: 10.1016/j.cognition.2023.105606. Online ahead of print.ABSTRACTThe basic-level advantage is one of the best-known effects in human categorisation. Traditional accounts argue that basic-level categories present a maximally informative or entry level into a taxonomic organisation of concepts in semantic memory. However, these explanations are not fully compatible with most recent views on the structure of the conceptual system such as linguistic-simulation accounts, which emphasise the dual role of sensorimotor (i.e., perception-action experience of the world) and linguistic distributi...
Source: Cognition - September 18, 2023 Category: Neurology Authors: Rens van Hoef Louise Connell Dermot Lynott Source Type: research
Quality of life in children suffering from headaches: a systematic literature review
ConclusionThere is a need for a condition-specific PROM to facilitate the measurement of QoL outcomes in the pediatric headache population. A conceptual model was developed based on the findings from the health concepts. Findings from this review could be used for future qualitative interviews with pediatric patients with headaches to elicit and refine important QoL concepts.
Source: The Journal of Headache and Pain - September 18, 2023 Category: Neurology Source Type: research
Functional neurological seizures and migraine: A systematic review and case series
CONCLUSION: Our systematic review and case series indicate that migraine attacks may trigger FND-seizures, perhaps more often that currently understood, and suggest that migraine prophylaxis may reduce FND-seizure frequency in such cases. To validate these observations, fully powered prospective investigations are required.PMID:37717461 | DOI:10.1016/j.yebeh.2023.109437
Source: Epilepsy and Behaviour - September 17, 2023 Category: Neurology Authors: Laura Duque Ivan Garza Gregory D Cascino Jeffrey P Staab Source Type: research
Refining of the electroclinical phenotype in familial and sporadic cases of CSNK2B-related Neurodevelopmental Syndrome
We report ten new patients with CSNK2B-related Neurodevelopmental Syndrome associated with heterozygous variants of CSNK2B. In three patients, a pathogenic variant was inherited from an affected parent. We describe both molecular and clinical features, focusing on epileptic and neurodevelopmental phenotypes. The median age at follow-up was 8.5 years (range 21 months-42 years). All patients had epilepsy, with onset at a median age of 10.5 months range 6 days-10 years). Seizures were both focal and generalized and were resistant to anti-seizure medications in two out of ten patients. Six patients had mild to moderate cogniti...
Source: Epilepsy and Behaviour - September 17, 2023 Category: Neurology Authors: Marina Trivisano Angela De Dominicis Fabrizia Stregapede Chiara Quintavalle Alessia Micalizzi Simona Cappelletti Maria Lisa Dentici Lorenzo Sinibaldi Costanza Calabrese Alessandra Terracciano Federico Vigevano Antonio Novelli Nicola Specchio Source Type: research
Transcending the amyloid-beta dominance paradigm in Alzheimer's disease: An exploration of behavioural, metabolic, and gut microbiota phenotypes in 5xFAD mice
Neurobiol Dis. 2023 Sep 15:106295. doi: 10.1016/j.nbd.2023.106295. Online ahead of print.ABSTRACTThe amyloid cascade hypothesis is widely accepted as an explanation for the neuropathological changes in Alzheimer's disease (AD). However, the role of amyloid-beta (Aβ) as the sole cause of these changes is being questioned. Using the 5xFAD mouse model of AD, we investigated various factors contributing to neuropathology, including genetic load (heterozygous (HTZ) versus homozygous (HZ) condition), behavioural phenotype, neuropathology markers, metabolic physiology, and gut microbiota composition at early (5 months of age) an...
Source: Neurobiology of Disease - September 17, 2023 Category: Neurology Authors: Dina Medina-Vera Emma N Zambrana-Infantes Antonio J L ópez-Gambero Julia Verheul-Campos Luis J Sant ín Elena Baixeras Juan Suarez Francisco J Pavon Cristina Rosell-Valle Fernando Rodr íguez de Fonseca Source Type: research
A murine model of BSCL2-associated Celia's encephalopathy
Neurobiol Dis. 2023 Sep 15:106300. doi: 10.1016/j.nbd.2023.106300. Online ahead of print.ABSTRACTCelia's encephalopathy or progressive encephalopathy with/without lipodystrophy is a neurodegenerative disease with a fatal prognosis in childhood. It is generally caused by the c.985C > T variant in the BSCL2 gene, leading to the skipping of exon 7 and resulting in an aberrant seipin protein (Celia-seipin). To precisely define the temporal evolution and the mechanisms involved in neurodegeneration, lipodystrophy and fatty liver in Celia's encephalopathy, our group has generated the first global knock-in murine model for the...
Source: Neurobiology of Disease - September 17, 2023 Category: Neurology Authors: Silvia Cobelo-G ómez Sof ía Sánchez-Iglesias Alberto R ábano Ana Senra Pablo Aguiar Noem í Gómez-Lado Lara Garc ía-Varela Iv án Burgueño-García Laura Lamp ón-Fernández Ant ía Fernández-Pombo Everardo Josu é Díaz-López Teresa Prado-Mora ñ Source Type: research
PIEZO1 expression at the glio-vascular unit adjusts to neuroinflammation in seizure conditions
Neurobiol Dis. 2023 Sep 15:106297. doi: 10.1016/j.nbd.2023.106297. Online ahead of print.ABSTRACTMechanosensors are emerging players responding to hemodynamic and physical inputs. Their significance in the central nervous system remains relatively uncharted. Using human-derived brain specimens or cells and a pre-clinical model of mesio-temporal lobe epilepsy (MTLE), we examined how the mRNA levels of the mechanosensitive channel PIEZO1 adjust to disease-associated pro-inflammatory trajectories. In brain tissue micro-punches obtained from 18 drug-resistant MTLE patients, PIEZO1 expression positively correlated with that of ...
Source: Neurobiology of Disease - September 17, 2023 Category: Neurology Authors: Valentin Garcia Marine Blaquiere Alicia Janvier Noemie Cresto Carla Lana Athenais Genin Helene Hirbec Etienne Audinat Adele Faucherre Emmanuel L Barbier Sophie Hamelin Philippe Kahane Chris Jopling Nicola Marchi Source Type: research
TSPO exacerbates acute cerebral ischemia/reperfusion injury by inducing autophagy dysfunction
Exp Neurol. 2023 Sep 15:114542. doi: 10.1016/j.expneurol.2023.114542. Online ahead of print.ABSTRACTAutophagy is considered a double-edged sword, with a role in the regulation of the pathophysiological processes of the central nervous system (CNS) after cerebral ischemia-reperfusion injury (CIRI). The 18-kDa translocator protein (TSPO) is a highly conserved protein, with its expression level in the nervous system closely associated with the regulation of pathophysiological processes. In addition, the ligand of TSPO reduces neuroinflammation in brain diseases, but the potential role of TSPO in CIRI is largely undiscovered. ...
Source: Experimental Neurology - September 17, 2023 Category: Neurology Authors: Yusufu Mahemuti Kaheerman Kadeer Riqing Su Abudureheman Abula Yirizhati Aili Aierpati Maimaiti Subinuer Abulaiti Maimaitiyasheng Maimaitituerxun Tong Miao Shihao Jiang Aximujiang Axier Maimaitili Aisha Yongxin Wang Xiaojiang Cheng Source Type: research
Iron chelation prevents nigrostriatal neurodegeneration in a chronic methamphetamine mice model
Neurotoxicology. 2023 Sep 15:S0161-813X(23)00122-5. doi: 10.1016/j.neuro.2023.09.006. Online ahead of print.ABSTRACTMethamphetamine (METH) has been established to selectively target and impair dopaminergic neurons through multiple pathways. Ferroptosis is a unique form of non-apoptotic cell death driven by cellular iron accumulation-induced lipid peroxidation. Nonetheless, it remains unclear whether METH can induce ferroptosis. In the present study, we sought to assess alterations in iron levels after chronic METH exposure and reveal the modulatory role of iron on METH-induced pathologies. Importantly, we demonstrated that...
Source: Neurotoxicology - September 17, 2023 Category: Neurology Authors: Shanshan Hu Xiaorong Huang Jian Huang Ying Qian Yingbiao Tian Ye Xiao Xiaolan Qi Xiaoxian Zhou Zhusheng Yang Zehui Chen Source Type: research
