Linalool Attenuates Hypothalamus Proteome Disturbance Facilitated by Methamphetamine Induced Neurotoxicity in Rats

Neurotoxicology. 2023 Sep 18:S0161-813X(23)00123-7. doi: 10.1016/j.neuro.2023.09.007. Online ahead of print.ABSTRACTBACKGROUND: One of the most powerful stimulants of the central nervous system is methamphetamine (METH). Linalool has a neuroprotective effect against ischemia injury by reducing oxidative stress and apoptosis. The present study investigated whether linalool can reverse the hypothalamus neurotoxicity and proteome disturbance in METH-treated rats.BRIEF METHOD: A total of 36 male albino rats were split into two equal groups (normal and METH-treated). Three equal subgroups of normal rats were created; Control, Linalool (25mg/kg), and Linalool (50mg/kg); Normal rats were given daily oral doses of 1ml of distilled water, 25mg/kg linalool, and 50mg/kg of linalool, respectively. METH groups were divided into 3 equal subgroups; METH-treated rats, Linalool (25mg/kg)+METH-treated, and Linalool (50mg/kg)+METH-treated subgroups; METH-treated rats received daily and oral doses of 1ml distilled water, 25mg/kg linalool, and 50mg/kg of linalool, respectively.RESULTS: According to the data obtained, METH caused a decrease of the sucrose preference test, travel distance test, and center square entries test, superoxide dismutase, glutathione peroxidase, catalase, NADPH oxidase, interleukin-10 but a rise in the center square duration test, tail suspension test, and forced swimming test, malondialdehyde, conjugated dienes, oxidative index, serotonin, dopamine, norepinephrine, γ-ami...
Source: Neurotoxicology - Category: Neurology Authors: Source Type: research