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Total 1421 results found since Jan 2013.

Low-grade disease activity in early life precedes childhood asthma and allergy.
In conclusion, the series of papers presented in this thesis (I-VII) evidence the presence of a pre-symptomatic disease process measurable in several body compartments, which supports the notion of low-grade disease activity in early life as a generic trait among neonates developing asthma and allergy. This hypothesis piggybacking on single biomarker assessments could be enforced and refined by applying novel global omics approaches. In particular, metabolomic analyses of serum, urine, and airway lining fluid from neonates as well as neonatal VOC profiling of exhaled breath may facilitate a broader understanding of the ear...
Source: Danish Medical Journal - August 2, 2016 Category: Journals (General) Tags: Dan Med J Source Type: research

What Proteins Cause Cow ’ s Milk Protein Allergy?
Discussion Cow’s milk protein allergy (CMPA) is one of the most common food allergies. It is estimated to have an incidence of 2-7.5% in infants and a prevalence of 0.5% in breastfeed infants. The prevalence decreases with age at 1% in children > or = 6 years. CMPA does not have a laboratory test and therefore is a clinical diagnosis. It is defined as a “hypersensitivity reaction brought on by specific immunologic mechanisms to cow’s milk.” Generally symptoms present within the first month of life and involve 2 of more systems with 2 or more symptoms. Systems are dermatologic (including atopic de...
Source: PediatricEducation.org - September 11, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Are vitamins A and D important in the development of food allergy and how are they best measured?
Abstract Food allergy has a dramatic impact on a child's (and their family's) quality of life and places a major financial burden on the community. It has been hypothesized that the increase in food allergy may relate to the concordant rise in prevalence of vitamin D insufficiency. More recently a second hypothesis has implicated vitamin A sufficiency in the development of immune tolerance. Together, these hypotheses have prompted investigation into the circulating levels of vitamins A and D in relation to food allergy prevalence. This review aims to examine the relationship between vitamins A and D and food aller...
Source: Clinical Biochemistry - February 19, 2014 Category: Biochemistry Authors: Zakariaeeabkoo R, Allen KJ, Koplin JJ, Vuillermin P, Greaves RF Tags: Clin Biochem Source Type: research

Association of blood eosinophilia and vitamin D insufficiency in young infants with cow milk allergy.
CONCLUSIONS: Low serum vitamin D associates with persistent blood eosinophilia and symptoms in young cow milk allergy infants. PMID: 31464401 [PubMed - in process]
Source: Asia Pacific Journal of Clinical Nutrition - August 30, 2019 Category: Nutrition Authors: Li J, Mei X, Cai X, Zhuo Y, Zhang L, Guo H, Yang H, Yang G Tags: Asia Pac J Clin Nutr Source Type: research

Food Allergy Prevention and Treatment by Targeted Nutrition
In view of the dramatic rise in the prevalence of food allergy globally, effective prevention strategies have become a public health priority. Several models have emerged around the etiology of food allergy, including the hygiene hypothesis, dual allergen exposure hypothesis, and vitamin D hypothesis. These form the basis for current and potential prevention strategies. Breastfeeding remains a key pillar of primary allergy prevention. Other nutritional interventions, including the use of whey-based, partially hydrolyzed formula in non-breastfed infants, also play an important role. In recent years, there has been a shift a...
Source: Annals of Nutrition and Metabolism - April 9, 2018 Category: Nutrition Source Type: research

No association between allergy and current 25‐hydroxy vitamin D in serum or vitamin D intake
ConclusionThe findings suggest no association between allergy and 25OHD levels in serum or vitamin D intake in adolescents. Serum 25OHD levels correlated to intake of vitamin D fortified lean milk.This article is protected by copyright. All rights reserved.
Source: Acta Paediatrica - January 21, 2015 Category: Pediatrics Authors: Malin Barman, Karin Jonsson, Bill Hesselmar, Agnes E. Wold, Ann‐Sofie Sandberg, Anna Sandin Tags: Regular Article Source Type: research

Important risk factors for the development of food allergy and potential options for prevention.
Authors: Koplin JJ, Allen KJ, Tang ML Abstract INTRODUCTION: Food allergy currently affects up to 10% of infants. Identification and implementation of effective food allergy prevention strategies is thus imperative. Areas covered: We focus on five food allergy risk factors/prevention strategies which have been or are currently being tested in randomised controlled trials: (1) timely introduction of allergenic foods into the infant diet; (2) maternal diet and consumption of allergenic foods during pregnancy and breastfeeding; (3) infant skin barrier and the role of moisturisers in early life; (4) infant Vitamin D le...
Source: Expert Review of Clinical Immunology - November 10, 2018 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research

Effect of Cholecalciferol in Food Allergy Mouse Model Is Associated with Decrease of CD69+ CD4+ T Cells.
In this study, we investigated the effect of supplementation with cholecalciferol, a widely used form of vitamin D3, on food allergy using an experimental mouse model. In wild-type BALB/c mice which were sensitized and challenged with an experimental allergen, ovalbumin, a clinical symptom of food allergy, diarrhea, was significantly induced with the elevation of immunoglobulin E level and the increases of T helper 2 cytokine productions, such as interleukin-4, -5, and -13 (p<0.05), whereas no change in T helper 1 cytokine production, such as interferon-γ, was observed. It was also found that cell population of CD69+ C...
Source: Journal of Nutritional Science and Vitaminology - May 9, 2019 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Effects of antioxidant supplements and nutrients on patients with asthma and allergies.
Abstract Asthma and allergic diseases have become a worldwide public health concern because of their increased prevalence. Despite decades of research on risk factors, the causes of these disorders are poorly understood. They are thought to develop through complex interactions between genetic and environmental factors. Because pulmonary and systemic oxidative stress increase inflammatory responses relevant to asthma and allergy, dietary or vitamin supplementation with antioxidants (a broad and varied category) has been proposed as an approach to reducing asthma incidence or morbidity. Meta-analyses of observationa...
Source: Clinical Lung Cancer - May 1, 2014 Category: Cancer & Oncology Authors: Moreno-Macias H, Romieu I Tags: J Allergy Clin Immunol Source Type: research

Is Low Vitamin D Status A Risk Factor For Food Allergy? Current Evidence And Future Directions.
Abstract Studies from several countries have reported an association between latitudes further from the equator and proxy markers of food allergy prevalence. As latitudes further from the equator are associated with lower sun exposure and vitamin D status (VDS), it has been proposed that low vitamin D status (VDS) may be a risk for food allergy. A range of basic science supports the biological plausibility of this hypothesis; and recent work has identified a cross sectional association between low VDS and challenge proven food allergy in infants. Overall, however, the evidence regarding the relationship between VD...
Source: Mini Reviews in Medicinal Chemistry - May 19, 2015 Category: Chemistry Authors: Molloy J, Ponsonby AL, Allen K, Tang ML, Collier F, Ward A, Koplin J, Vuillermin P Tags: Mini Rev Med Chem Source Type: research

IJERPH, Vol. 15, Pages 1245: Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood —Lack of Association with Tobacco Smoke Exposure
IJERPH, Vol. 15, Pages 1245: Vitamins A and E during Pregnancy and Allergy Symptoms in an Early Childhood—Lack of Association with Tobacco Smoke Exposure International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15061245 Authors: Jolanta Gromadzinska Kinga Polanska Lucyna Kozlowska Karolina Mikolajewska Iwona Stelmach Joanna Jerzyńska Włodzimierz Stelmach Mariusz Grzesiak Wojciech Hanke Wojciech Wasowicz Epidemiological studies have suggested an association between maternal antioxidant levels during pregnancy and development of allergic diseases in their offspring. T...
Source: International Journal of Environmental Research and Public Health - June 12, 2018 Category: Environmental Health Authors: Jolanta Gromadzinska Kinga Polanska Lucyna Kozlowska Karolina Mikolajewska Iwona Stelmach Joanna Jerzy ńska W łodzimierz Stelmach Mariusz Grzesiak Wojciech Hanke Wojciech Wasowicz Tags: Article Source Type: research

From the pages of AllergyWatch June 2019
This study examined innate immune profiles associated with the development of egg allergy and natural tolerance in childhood, including the effects of serum vitamin D. The study used peripheral blood mononuclear cell samples longitudinally collected from 54 infants enrolled in the population-based HealthNuts study: 36 who had egg allergy at age 1 year and 18 with no food allergy.
Source: Annals of Allergy, Asthma and Immunology - March 21, 2019 Category: Allergy & Immunology Authors: Stanley M. Fineman, David A. Khan, John J. Oppenheimer Source Type: research

Food allergy prevention: current evidence
Purpose of review The aim of the article is to critically appraise the most relevant studies in the rapidly advancing field of food allergy prevention. Recent findings Epidemiologic studies identified atopic dermatitis as a strong risk factor for food allergy, with mounting evidence for impaired skin barrier and cutaneous inflammation in the pathogenesis. Additional risk factors include a family history of atopy, the timing of allergenic food introduction into the infant's diet, dietary diversity, vitamin D, and environmental factors, such as dog ownership. Early introduction of allergenic foods (such as peanut) into ...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - April 1, 2020 Category: Nutrition Tags: PAEDIATRICS: Edited by Berthold Koletzko and Raanan Shamir Source Type: research

Allergy Prevention: An Overview of Current Evidence.
Authors: Royal C, Gray C Abstract Background: There has been a rapid rise in allergic disorders across the globe. This has increased research into the determinants of allergy development, to identify factors that may be manipulated to mitigate risk. An opportune window in immunological development appears to exist in early life whereby certain exposures may promote or prevent the development of an allergic disposition. Furthermore, factors that affect the composition and diversity of the microbiome in early life have been explored. In this review, we discuss current literature and recommendations relating to exposu...
Source: The Yale Journal of Biology and Medicine - January 1, 2021 Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research

Evaluation of red meat allergy patients and review of the literature
CONCLUSIONS: Clinical and laboratory findings were heterogeneous in children with red meat allergy. Anaphylaxis risk seems to be higher than other food allergies. OFC test is more helpful in both diagnosis and alternative red meat selection compared to laboratory findings.PMID:34738365 | DOI:10.24953/turkjped.2021.05.011
Source: The Turkish Journal of Pediatrics - November 5, 2021 Category: Pediatrics Authors: Şeyhan Kutluğ Gonca Hanc ıoğlu Şefika İlknur Karadağ-Kökçü Recep Sancak Fad ıl Öztürk Source Type: research