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What Proteins Cause Cow ’ s Milk Protein Allergy?

Discussion Cow’s milk protein allergy (CMPA) is one of the most common food allergies. It is estimated to have an incidence of 2-7.5% in infants and a prevalence of 0.5% in breastfeed infants. The prevalence decreases with age at 1% in children> or = 6 years. CMPA does not have a laboratory test and therefore is a clinical diagnosis. It is defined as a “hypersensitivity reaction brought on by specific immunologic mechanisms to cow’s milk.” Generally symptoms present within the first month of life and involve 2 of more systems with 2 or more symptoms. Systems are dermatologic (including atopic dermatitis, urticaria, oral pruritis), respiratory (including asthma, stridor, wheezing, rhinoconjunctivitis) and gastrointestinal (including emesis, diarrhea, constipation, malabsorption, gastroestophageal reflux disease) and other symptoms may include colic, irritability, failure to thrive or food aversion. IgE-mediated CMPA (Type 1 hypersensitivity reaction, ~50% of children) has symptoms that occur within minutes to 2 hours of ingestion of the CMP. Non-IgE mediated CMPA (Type 4 delayed hypersensitivity reaction) has symptoms that occur 4 or more hours (even up to 1 week) after exposure to CMP. Allergic colitis can have blood mixed into stools that are usually non-foul smelling, mucousy or foamy. Blood can be hematochezia or melanotic or insidious. The mechanism for rectal bleeding is felt to be ulceration of thinned mucosa that is stretched over enlarged h...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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Objectives/HypothesisThe goal of the study was to perform a systematic review with meta‐analysis to determine the mean change in the 22‐item Sino‐Nasal Outcome Test (SNOT‐22) across patients who have had endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) in the literature. MethodsA literature search was performed to identify studies that assessed SNOT‐22 scores before and after ESS in adult patients with CRS. A random effects model with inverse variance weighting was used to generate the mean change after surgery, along with the forest plot and 95% confidence interval (CI). The impact of patient‐sp...
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Systematic Review Source Type: research
CONCLUSIONS: In this observational study, the guideline-recommended ticagrelor-based primary DAPT regimen was associated with an increased event risk in consecutive ACS patients treated with newer-generation DES. PMID: 29151439 [PubMed - in process]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
Summary BackgroundOxidative stress (OS) has an important effect on the pathogenesis of atopic dermatitis (AD). Thiols are antioxidants that regulate intracellular redox metabolism and protect keratinocytes against OS damage in the stratum corneum. AimTo investigate dynamic thiol‐disulphide homeostasis (dTDH) as a novel OS parameter in children with AD, and its relationship with disease severity and chronicity. MethodsSeverity of AD was determined by using the instruments SCORing Atopic Dermatitis (SCORAD) and Eczema Area And Severity Index (EASI) upon enrolment in the study (SCORAD1 and EASI1) and after 1 year (SCOR...
Source: Clinical And Experimental Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
Authors: Norlien KG, Landsteiner A, Carlson A Abstract Cosmetologists face a variety of occupational health and safety challenges. To gather information on respiratory issues related to work as a cosmetologist, licensed cosmetologists were invited by e-mail to participate in a short online survey. The survey collected demographic data, work history, respiratory symptoms, product usage, and health and safety training. Results revealed that while 57% of cosmetologists reported having received training on customer or consumer safety, only 10.5% had received training on worker health such as work-related asthma and/or ...
Source: Journal of Environmental Health - Category: Environmental Health Tags: J Environ Health Source Type: research
Abstract IgE and not IgG is usually associated with allergy. IgE lodged on mast cells in skin or gut and basophils in the blood allows for the prolonged duration of allergy through the persistent expression of high affinity IgE receptors. However, many allergic reactions are not dependent on IgE and are generated in the absence of allergen specific and even total IgE. Instead, IgG plasma cells are involved in induction of, and for much of the pathogenesis of, allergic diseases. The pattern of IgG producing plasma cells in atopic children and the tendency for direct or further class switching to IgE are the principle factor...
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: Review Source Type: research
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Source: Allergy - Category: Allergy & Immunology Authors: Tags: Brief Communication Source Type: research
BY SHANNON BROWNLEE On Wednesday, October 25, 2017 I was at the inaugural Society for Participatory Medicine conference. It was a fantastic day and the ending keynote was the superb Shannon Brownlee. It was great to catch up with her and I’m grateful that she agreed to let THCB publish her speech. Settle back with a cup of coffee (or as it’s Thanksgiving, perhaps something stronger), and enjoy–Matthew Holt George Burns once said, the secret to a good sermon is to have a good beginning and a good ending—and to have the two as close together as possible. I think the same is true of final keynotes aft...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: OP-ED Patients Physicians Lown Institute Overtreatment Right Choice Alliance Shannon Brownlee Society for Participatory Medicine Source Type: blogs
CONCLUSIONS: No specific antiviral treatment is available and no consensus has been reached on the appropriate treatment for anogenital warts. No data are available to indicate whether treatment eliminates infectivity, the primary aim of treatment being to remove the lesions. There is a paucity of published randomized trials. Despite the introduction of antiviral treatments such as interferon or imiquimod, surgical destruction or removal remains the treatment of choice. PMID: 29154519 [PubMed - as supplied by publisher]
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
No relevant change in allergen - specific/total IgE levels for subjects challenged with omalizumab
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: ENT, Pharmacy, Pulmonology, Allergy, Journal, Source Type: news
Conclusion TCC, BF, and EE show a significant subjective improvement in symptoms of obstructed evacuation and in quality of life, regardless of the reversal of the paradoxical puborectalis contraction.
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
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