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Infectious Disease: Adenoviruses

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Total 599 results found since Jan 2013.

MiR-30c-5p ameliorates hepatic steatosis in leptin receptor-deficient (db/db) mice via down-regulating FASN.
In this study, we observed a significant reduction of miR-30c-5p in the liver of leptin receptor-deficient (db/db) mice. Remarkably, recombinant adeno-associated virus (rAAV)-mediated delivery of miR-30c-5p was sufficient to attenuate triglyceride accumulation and hepatic steatosis in db/db mice. Through computational prediction, KEGG analysis and Ago2 co-immunoprecipitation, we identified that miR-30c-5p directly targeted fatty acid synthase, a key enzyme in fatty acid biosynthesis. Moreover, down-regulation of FASN by siRNA attenuated some key features of NAFLD, including decreased triglyceride accumulate and lipid depos...
Source: Oncotarget - January 16, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Recombinant adeno-associated virus expressing a p53-derived apoptotic peptide (37AA) inhibits HCC cells growth in vitro and in vivo.
In this study, we successfully constructed a recombinant rAAV expressing 37AA. In vitro and in vivo assays showed that transfection of NT4-37AA/rAAV in HCC cells strongly suppressed cell proliferation, induced apoptosis, and up-regulated the cellular expression of p73. NT4-37AA/rAAV transfection markedly slowed Huh-7 xenografted tumor growth in murine. Pretreatment of HCC cells with p73 siRNA abrogated these effects of NT4-37AA/rAAV. Furthermore, we found that expression of p73 was upregulated and the formation of P73/iASSP complex was prevented when 37AA was introduced into HCC cells. Taken together, these results indicat...
Source: Oncotarget - February 13, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Protein kinase CK2 α catalytic subunit ameliorates diabetic renal inflammatory fibrosis via NF-κB signaling pathway.
This study indicates the essential role of CK2α in regulating the diabetic renal pathological process of inflammatory fibrosis via NF-κB pathway, and inhibition of CK2α may serve as a promising therapeutic strategy for diabetic nephropathy. PMID: 28237649 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - February 21, 2017 Category: Drugs & Pharmacology Authors: Huang J, Chen Z, Li J, Chen Q, Li J, Gong W, Huang J, Liu P, Huang H Tags: Biochem Pharmacol Source Type: research

Hypoxia-inducible lipid droplet-associated (HILPDA) is not a direct physiological regulator of lipolysis in adipose tissue.
Abstract Triglycerides are stored in specialized organelles called lipid droplets. Numerous proteins have been shown to be physically associated with lipid droplets and govern their function. Previously, hypoxia-inducible lipid droplet-associated (HILPDA) was localized to lipid droplets and was suggested to inhibit triglyceride lipolysis in hepatocytes. We confirm the partial localization of HILPDA to lipid droplets and show that HILPDA is highly abundant in adipose tissue, where its expression is controlled by the peroxisome proliferator-activated receptor γ and by β-adrenergic stimulation. Levels of HILPDA mar...
Source: Endocrinology - March 17, 2017 Category: Endocrinology Authors: Dijk W, Mattijssen F, de la Rosa Rodriguez M, Loza Valdes A, Loft A, Mandrup S, Kalkhoven E, Qi L, Borst JW, Kersten S Tags: Endocrinology Source Type: research

Epigenetic upregulation of CXCL12 expression mediates antitubulin chemotherapeutics–induced neuropathic pain
Abstract: Clinically, Microtubule-targeted agents–induced neuropathic pain hampers chemotherapeutics for patients with cancer. Here, we found that application of paclitaxel or vincristine increased the protein and mRNA expression of CXCL12 and frequency and amplitude of miniature excitatory post synaptic currents (mEPSCs) in spinal dorsal horn neurons. Spinal local application of CXCL12 induced the long-term potentiation of nociceptive synaptic transmission and increased the amplitude of mEPSCs. Inhibition of CXCL12 using the transgenic mice (CXCL12−/+) or neutralizing antibody or siRNA ameliorated the mEPSC's enhancem...
Source: Pain - March 25, 2017 Category: Anesthesiology Tags: Research Paper Source Type: research

A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity Lipids
Impaired adipogenic differentiation during diet-induced obesity (DIO) promotes adipocyte hypertrophy and inflammation, thereby contributing to metabolic disease. Adenomatosis polyposis coli down-regulated 1 (APCDD1) has recently been identified as an inhibitor of Wnt signaling, a key regulator of adipogenic differentiation. Here we report a novel role for APCDD1 in adipogenic differentiation via repression of Wnt signaling and an epigenetic linkage between miR-130 and APCDD1 in DIO. APCDD1 expression was significantly up-regulated in mature adipocytes compared with undifferentiated preadipocytes in both human and mouse sub...
Source: Journal of Biological Chemistry - April 14, 2017 Category: Chemistry Authors: Nicole K. H. Yiew, Tapan K. Chatterjee, Yao Liang Tang, Rod Pellenberg, Brian K. Stansfield, Zsolt Bagi, David J. Fulton, David W. Stepp, Weiqin Chen, Vijay Patel, Vinayak M. Kamath, Sheldon E. Litwin, David Y. Hui, Steven M. Rudich, Ha Won Kim, Neal L. W Tags: Cell Biology Source Type: research

CMTM3 (CKLF-Like Marvel Transmembrane Domain 3) Mediates Angiogenesis by Regulating Cell Surface Availability of VE-Cadherin in Endothelial Adherens Junctions.
CONCLUSIONS: In this study, we have identified a new regulatory function for CMTM3 in angiogenesis. CMTM3 is involved in VE-cadherin turnover and is a regulator of the cell surface pool of VE-cadherin. Therefore, CMTM3 mediates cell-cell adhesion at adherens junctions and contributes to the control of vascular sprouting. PMID: 28428220 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 20, 2017 Category: Cardiology Authors: Chrifi I, Louzao-Martinez L, Brandt M, van Dijk CGM, Burgisser P, Zhu C, Kros JM, Duncker DJ, Cheng C Tags: Arterioscler Thromb Vasc Biol Source Type: research

PAR1 ‑mediated c‑Jun activation promotes heat stress‑induced early stage apoptosis of human umbilical vein endothelial cells.
PAR1‑mediated c‑Jun activation promotes heat stress‑induced early stage apoptosis of human umbilical vein endothelial cells. Mol Med Rep. 2017 Mar 09;: Authors: Zhang S, Liu Y, Wang Z, Liu J, Gu Z, Xu Q, Su L Abstract Our previous study indicated that when human umbilical vein endothelial cells (HUVECs), which are involved in endothelial barrier function, are heat stressed, levels of protease‑activated receptor 1 (PAR1) are increased significantly. In the present study, it was demonstrated that PAR1 serves a vital role in heat stress‑induced HUVEC apoptosis. When the PAR1 inhibitor, SCH79797 ...
Source: Molecular Medicine Reports - April 29, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.
In this study, we determined whether inhibition of protein kinase CK2 and the resultant stabilisation of proline-rich homeodomain (PRH) could suppress VSMC proliferation. Both silencing and pharmacological inhibition of CK2 with K66 antagonised replication of isolated VSMCs. SiRNA-induced knockdown as well as ectopic overexpression of proline-rich homeodomain indicated that PRH disrupts cell cycle progression. Mutation of CK2 phosphorylation sites Ser(163) and Ser(177) within the PRH homeodomain enabled prolonged cell cycle arrest by PRH. Concomitant knockdown of PRH and inhibition of CK2 with K66 indicated that the anti-p...
Source: Vascular Pharmacology - September 16, 2017 Category: Drugs & Pharmacology Authors: Wadey KS, Brown BA, Sala-Newby GB, Jayaraman PS, Gaston K, George SJ Tags: Vascul Pharmacol Source Type: research

GSE87554 Genome-wide transcriptional profiling of YAP target genes in human endothelial cells
Contributors : Suowen Xu ; Zheng G Jin ; John M Ashton ; Jason R MyersSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndothelial cell is the major cell type that senses and transduces mechanosignal generated by shear stress. We have recently shown that Hippo/YAP pathway is a mechanosensitive pathway that is critical for maintaining endothelial cell homeostasis. However, the transcritpional targets and biological functions of YAP in endothelial cells remain largely unknown. To evaluate YAP-dependent gene expression in endothelial cells, we performed RNA-sequencing in YAP depleted (by ...
Source: GEO: Gene Expression Omnibus - October 3, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Olig2 Silence Ameliorates Cuprizone-Induced Schizophrenia-Like Symptoms in Mice.
CONCLUSIONS Cuprizone-induced schizophrenia-like symptoms involved olig2 upregulation. The silence of olig2 could prevent changes, likely through regulating MBP, CNPase, and GFAP expressions. PMID: 28989170 [PubMed - in process]
Source: Medical Science Monitor - October 12, 2017 Category: Research Tags: Med Sci Monit Source Type: research

CIDEC Gene Silencing Alleviates Pulmonary Vascular Remodeling in a Type 2 Diabetic Rat Model
ConclusionsCIDEC/AMPK signaling pathway could be a potential therapeutic candidate against pulmonary vascular diseases in type 2 diabetes.This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - September 1, 2017 Category: Endocrinology Authors: Dong ‐xin Sui, Hui‐min Zhou, Feng Wang, Ming Zhong, Wei Zhang, Yun Ti Tags: Original Article Source Type: research

The mechanism of all-trans retinoic acid in the regulation of apelin expression in vascular endothelial cells.
Abstract The apelin gene can promote vascular endothelial cell (VEC) proliferation, migration and angiogenesis. However, the molecular mechanism for regulation of the apelin gene is still unknown. Real-time PCR and Western blotting analysis were employed to detect the effect of all-trans retinoic acid (ATRA) in up-regulating apelin expression in human umbilical vein endothelial cells (HUVECs). Furthermore, the in vivo study also indicated that ATRA could increase apelin expression in balloon-injured arteries of rats, which is consistent with the results from the cultured HUVECs. To ensure whether retinoic acid rec...
Source: Bioscience Reports - October 25, 2017 Category: Biomedical Science Authors: Shi H, Yuan L, Yang H, Zang A Tags: Biosci Rep Source Type: research

KIF3A knockdown sensitizes bronchial epithelia to apoptosis and aggravates airway inflammation in asthma.
CONCLUSION: KIF3A plays an important role in epithelium apoptosis and bronchial inflammation in asthma, and may be a potential target for asthma treatment. PMID: 29156524 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 15, 2017 Category: Drugs & Pharmacology Authors: Geng G, Du Y, Dai J, Tian D, Xia Y, Fu Z Tags: Biomed Pharmacother Source Type: research

Nitric oxide promotes epidermal stem cell proliferation via FOXG1-c-Myc signalling
Conclusion This study showed that the biphasic effect of NO on ESC proliferation as well as NO induced ESC proliferation were regulated by the cGMP/FOXG1/c-Myc signalling pathway, suggesting that NO may serve as a new disparate target for wound healing.
Source: Nitric Oxide - December 14, 2017 Category: Chemistry Source Type: research