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Functional MRI of Letter Cancellation Task Performance in Older Adults
Conclusion The present work is the first to identify neural correlates of the LCT using fMRI and tablet technology in a healthy aging population. Across all ages, the activation was found to be bilateral, including in the cerebellum, superior temporal lobe, precentral gyrus, frontal gyrus, and various occipital and parietal areas. With increasing age, performance generally decreased and brain activity was reduced in the supplementary motor area, middle and inferior frontal gyrus, middle occipital gyrus, putamen and cerebellum. Better LCT performance was correlated with increased activity in the middle frontal gyrus, and r...
Source: Frontiers in Human Neuroscience - April 15, 2019 Category: Neuroscience Source Type: research

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway
Conclusion The data in this manuscript demonstrates that apelin-13 upregulates BDNF against STZ-induced congnitive impairment by suppressing glial cell activity and inflammatory factors release. This suggests apelin signaling may be a new target in the treatment of AD. Ethics Statement All experimental protocols were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals approved by the Central South University at XiangYa Animal Care and Use Committee. Author Contributions XqQ and LH conceived the study and contributed to its experimental design. HqL carried out the...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Train your brain, change your brain
(D'Or Institute for Research and Education) Less than one hour of brain training with neurofeedback leads to a strengthening of neural connections and communication among brain areas. This is the main finding of a new study conducted at D'Or Institute for Research and Education (IDOR), published today in Neuroimage. According to the authors, the study may pave the way for the optimization and development of therapeutic approaches against stroke and Parkinson's, for example.
Source: EurekAlert! - Medicine and Health - April 14, 2019 Category: International Medicine & Public Health Source Type: news

Virtual reality during gait training: does it improve gait function in persons with central nervous system movement disorders? A systematic review and meta-analysis.
CONCLUSION: VR-enhanced gait training is an effective method to improve spatiotemporal and functional parameters in persons with CNS movement disorders. Current evidence supports that, in comparison to training without VR, for people post-stroke VR-enhanced gait training is more effective to improve gait function. Future research regarding other outcome measures and other CNS movement disorders is necessary. PMID: 30814368 [PubMed - in process]
Source: NeuroRehabilitation - March 4, 2019 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

Does a perturbation based gait intervention enhance gait stability in fall prone stroke survivors? A pilot study - Punt M, Bruijn SM, van de Port IG, de Rooij IJM, Wittink H, van Dieen JH.
A recent review indicated that perturbation based training (PBT) interventions are effective in reducing falls in older adults and patients with Parkinson's disease. It is unknown whether this type of intervention is effective in stroke survivors. We deter...
Source: SafetyLit - January 29, 2019 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Does a Perturbation Based Gait Intervention Enhance Gait Stability in Fall Prone Stroke Survivors? A Pilot Study.
Authors: Punt M, Bruijn SM, van de Port IG, de Rooij IJM, Wittink H, van Dieën JH Abstract A recent review indicated that perturbation based training (PBT) interventions are effective in reducing falls in older adults and patients with Parkinson's disease. It is unknown whether this type of intervention is effective in stroke survivors. We determined whether PBT can enhance gait stability in stroke survivors. Ten chronic stroke survivors who experienced falls in the past six months participated in the PBT. Participants performed 10 training sessions over a six-week period. The gait training protocol was progressiv...
Source: Journal of Applied Biomechanics - January 25, 2019 Category: Sports Medicine Tags: J Appl Biomech Source Type: research

The effects of relaxation training on depression and anxiety in people living with long-term neurological conditions.
CONCLUSION: Relaxation training is proposed as a clinically effective treatment for anxiety and depression in people living with long-term neurological conditions, which could in turn lead to better functional outcomes of neurorehabilitation. The program investigated here has additional benefits of being delivered in people's own homes, which overcomes barriers to attending hospital, and is consistent with trends towards home as opposed to hospital care. This program may also be less costly to administer as it can be delivered as part of a stepped-care program by therapy assistants under supervision from qualified staff, a...
Source: Disability and Rehabilitation - January 17, 2019 Category: Rehabilitation Authors: Hampson N, King L, Eriksson LM, Smee H Tags: Disabil Rehabil Source Type: research

Economic evaluations of physiotherapy interventions for neurological disorders: a systematic review.
CONCLUSIONS: There are limited studies that have evaluated the cost-effectiveness of physiotherapy treatments in neurological disorders. Three studies that combined extra physiotherapy-by-physiotherapy assistant and novel interventions with conventional physiotherapy were found not cost-effective. Implications for Rehabilitation Progressive muscle strengthening exercise over a period of 6-month is reported to be cost-effective for falls prevention in people with Parkinson's disease Aerobic training is reported as potentially cost-effective for older adults with vascular cognitive impairment Physiotherapy given as an adjuva...
Source: Disability and Rehabilitation - January 7, 2019 Category: Rehabilitation Authors: Winser S, Lee SH, Law HS, Leung HY, Bello UM, Kannan P Tags: Disabil Rehabil Source Type: research

Effect of expiratory muscle strength training on cough and swallowing in patients with dysphagia following stroke
Conclusion: EMT had improved on not only the coughing function but also swallowing function for a stroke patient with dysphagia. These results suggest that EMT leads to improvement of airway clearance and reduction of aspiration risk, and may be expected as a means to prevent aspiration pneumonia.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Tawara, Y., Fujishima, I., Katagiri, N., Arizono, S., Ohgi, S., Kozu, R. Tags: Physiotherapists Source Type: research

The BOLD response in primary motor cortex and supplementary motor area during kinesthetic motor imagery based graded fMRI neurofeedback
This study has important implications for fMRI-NF protocols that employ motor imagery to modulate activity in specific target regions of the brain and to determine how they may be tailored for neurorehabilitation.
Source: NeuroImage - September 11, 2018 Category: Neuroscience Source Type: research

First-Person Perspective Action Observation Training in Individuals With Parkinson's Disease: A Consideration-of-Concept Controlled Pilot Trial
Conclusions: This pilot study suggests that FPP AOT is a feasible intervention and the research protocol designed would be suitable, with minor modifications, for the conduction of a subsequent stage 2 trial designed to verify the hypothesis that the adjunct of FPP AOT might improve motor performance in individuals with IPD.
Source: Journal of Geriatric Physical Therapy - June 20, 2018 Category: Physiotherapy Tags: Research Reports Source Type: research

Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson's disease? A pilot study.
Abstract Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can boost motor performance in Parkinson's disease (PD) when it is applied at rest. However, the potential supplementary therapeutic effect of the concurrent application of tDCS during the training of motor tasks is largely unknown. The present study examined the effects of tDCS on upper limb motor blocks during a freezing-provoking writing task (the funnel task) requiring up- and down-stroke movements at alternating amplitudes. Ten PD patients and 10 age-matched controls underwent two sessions of writing combined with 20 ...
Source: Human Movement Science - February 28, 2018 Category: Neurology Authors: Broeder S, Heremans E, Pinto Pereira M, Nackaerts E, Meesen R, Verheyden G, Nieuwboer A Tags: Hum Mov Sci Source Type: research

ReWalk Robotics touts Harvard-led Restore soft exosuit study
ReWalk Robotics (NSDQ:RWLK) today released results from a study of a soft suit exoskeleton system designed to aid ambulatory stroke patients, touting that the system was able to facilitate normal walking ability in patients. The study was authored by researchers at Harvard University’s Wyss Institute for Biologically Inspired Engineering and Boston University, and utilized a prototype that Marlborough, Mass.-based ReWalk Robotics plans to commercialize as the Restore system. Results from the study were published in the Journal of Science Translational Medicine. The Restore system is designed to transmit power to ke...
Source: Mass Device - August 2, 2017 Category: Medical Devices Authors: Fink Densford Tags: Clinical Trials Prosthetics Robotics ReWalk Robotics Source Type: news

Does Perturbation Training Prevent Falls after Discharge from Stroke Rehabilitation? A Prospective Cohort Study with Historical Control
This study aimed to determine if PBT during inpatient stroke rehabilitation can prevent falls after discharge into the community.
Source: Journal of Stroke and Cerebrovascular Diseases - June 1, 2017 Category: Neurology Authors: Avril Mansfield, Alison Schinkel-Ivy, Cynthia J. Danells, Anthony Aqui, Raabeae Aryan, Louis Biasin, Vincent G. DePaul, Elizabeth L. Inness Source Type: research

Perturbation ‐based balance training for falls reduction among older adults: Current evidence and implications for clinical practice
Falls are a leading cause of injury, hospitalization and even death among older adults. Although various strength and balance exercise interventions have shown moderate reductions in falls incidence among healthy older adults, no significant falls incidence improvements have been consistently seen in frail older adults or in patient groups with an increased falls risk (e.g. people with Parkinson's disease and stroke). This might be due to a lack of task specificity of previous exercise interventions to the recovery actions required to prevent a fall. Perturbation‐based balance training (PBT) is an emerging task‐specifi...
Source: Geriatrics and Gerontology International - May 1, 2017 Category: Geriatrics Authors: Marissa H.G. Gerards, Christopher McCrum, Avril Mansfield, Kenneth Meijer Tags: Review Article Source Type: research

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