Does a perturbation based gait intervention enhance gait stability in fall prone stroke survivors? A pilot study - Punt M, Bruijn SM, van de Port IG, de Rooij IJM, Wittink H, van Dieen JH.

A recent review indicated that perturbation based training (PBT) interventions are effective in reducing falls in older adults and patients with Parkinson's disease. It is unknown whether this type of intervention is effective in stroke survivors. We deter...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

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Abstract Neurological diseases particularly Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and epilepsy are on the rise all around the world causing morbidity and mortality globally with a common symptom of gradual loss or impairment of motor behaviour. Striatum, which is a component of the basal ganglia, is involved in facilitating voluntary movement while the cerebellum is involved in the maintenance of balance and coordination of voluntary movements. Dopamine, serotonin, gamma-aminobutyric acid (GABA), and glutamate, to name a few, interact in regulating the excitation and inhibition of motor neuro...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In patients with acute-onset paraparesis inferior, the concurrent presence of new onset cortical signs (abulia or mutism), and more rarely extrapyramidal signs, should alert clinicians to consider acute anterior bihemispheric ischemia. Prompt recognition of this rare form of acute cerebral stroke can enable timely delivering of acute thrombolytic or endovascular treatment.
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: All Imaging, All Clinical Neurology, Clinical neurology examination, Parkinson's disease/Parkinsonism, All Cerebrovascular disease/Stroke Case Source Type: research
(Ecole Polytechnique F é d é rale de Lausanne) The Defitech Foundation has teamed up with EPFL, CHUV and UNIL to widen access to the groundbreaking neurotechnology developed under the 2018 STIMO study, which allowed paraplegic patients to walk again. Their aim is also to develop new neurosurgical treatments for people suffering from Parkinson's disease or from neurological disorders following a head injury or stroke.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
AbstractAutophagy is a highly conservedcellular degradation process involving lysosomal degradation for the turnover of proteins, protein complexes, and organelles. Defects in autophagy produces impaired intercellular communication and have subsequently been shown to be associated with pathological conditions, including neurodegenerative diseases. Curcumin is a polyphenol found in the rhizome ofCurcuma longa, which has been shown to exert health benefits, such as antimicrobial, antioxidant, anti ‐inflammatory, and anticancer effects. There is increasing evidence in the literature revealing that autophagy modulation may p...
Source: IUBMB Life - Category: Research Authors: Tags: CRITICAL REVIEW Source Type: research
Abstract The gut microbiome - the largest reservoir of microorganisms of the human body - is emerging as an important player in neurodevelopment and ageing as well as in brain diseases including stroke, Alzheimer's disease and Parkinson's disease. The growing knowledge on mediators and triggered pathways has advanced our understanding of the interactions along the gut-brain axis. Gut bacteria produce neuroactive compounds and can modulate neuronal function, plasticity and behavior. Furthermore, intestinal microorganisms impact the host's metabolism and immune status which in turn affect neuronal pathways in the en...
Source: Current Opinion in Neurobiology - Category: Neurology Authors: Tags: Curr Opin Neurobiol Source Type: research
AbstractAutophagy is a highly conservedcellular degradation process involving lysosomal degradation for the turnover of proteins, protein complexes, and organelles. Defects in autophagy produces impaired intercellular communication and have subsequently been shown to be associated with pathological conditions, including neurodegenerative diseases. Curcumin is a polyphenol found in the rhizome ofCurcuma longa, which has been shown to exert health benefits, such as antimicrobial, antioxidant, anti ‐inflammatory, and anticancer effects. There is increasing evidence in the literature revealing that autophagy modulation may p...
Source: IUBMB Life - Category: Research Authors: Tags: CRITICAL REVIEW Source Type: research
Condition:   Parkinson Disease Intervention:   Device: Deep Brain Stimulation Sponsors:   Northwell Health;   National Institute of Neurological Disorders and Stroke (NINDS);   The University of Tennessee, Knoxville Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Treatment of neurological diseases using systemic and non-surgical techniques presents a significant challenge in medicine. This challenge is chiefly associated with the condensation and coherence of the brain tissue. The coherence structure of the brain is due to the presence of the blood brain barrier (BBB), which consists of a continuous layer of capillary endothelial cells. The BBB prevents most drugs from entering the brain tissue and is highly selective, permitting only metabolic substances and nutrients to pass through. Although this challenge has caused difficulties for the treatment of neurologic...
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research
In conclusion, T2D impairs vascular function by dysregulated autophagy. Therefore, autophagy could be a potential target for overcoming diabetic microvascular complications. To What Degree Does Loss of Skeletal Muscle with Age Contribute to Immunosenescence? https://www.fightaging.org/archives/2019/11/to-what-degree-does-loss-of-skeletal-muscle-with-age-contribute-to-immunosenescence/ Sarcopenia, the progressive loss of muscle mass and strength, is characteristic of aging. A perhaps surprisingly large fraction of the losses can be averted by strength training, but there are nonetheless inexorable process...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Quan Y, Ma A, Yang B Abstract Neurological dysfunction and death are common events leading to acute and chronic neurodegenerative diseases. Neurodegenerative disorders such as Alzheimer's and Parkinson's disease account for a significant and increasing proportion of morbidity and mortality in the developed world. Ganoderma lucidum (G. lucidum, Lingzhi), one of highly nutritious and significantly effective medicinal herbs, has been used for clinical applications for thousands of years. Several researches have shown that it has a wide range of brain damage protection, such as amelioration of Alzheimer's dise...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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