Functional MRI of Letter Cancellation Task Performance in Older Adults
Functional MRI of Letter Cancellation Task Performance in Older Adults Ivy D. Deng1, Luke Chung2, Natasha Talwar3,4, Fred Tam1, Nathan W. Churchill3, Tom A. Schweizer3,4,5,6† and Simon J. Graham1,2*† 1Physical Sciences Platform, Sunnybrook Research Institute (SRI), Toronto, ON, Canada 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada 3Neuroscience Research Program, Keenan Research Centre for Biomedical Science, Toronto, ON, Canada 4Institute of Medical Science, University of Toronto, Toronto, ON, Canada 5Division of Neurosurgery, St. Michael’s Hospital, Toronto, ON, Canada 6Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada The Letter Cancellation Task (LCT) is a widely used pen-and-paper probe of attention in clinical and research settings. Despite its popularity, the neural correlates of the task are not well understood. The present study uses functional magnetic resonance imaging (fMRI) and specialized tablet technology to identify the neural correlates of the LCT in 32 healthy older adults between 50–85 years of age, and further investigates the effect of healthy aging on performance. Subjects performed the LCT in its standard pen-and-paper administration and with the tablet during fMRI. Performance on the tablet was significantly slower than on pen-and-paper, with both response modes showing slower performance as a function of age. Across all ages, bilateral...
Publication date: Available online 24 May 2020Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Maira Jaqueline da Cunha, Katia Daniele Rech, Ana Paula Salazar, Aline Souza Pagnussat
ConclusionThe proposed multiparametric MRI-based SLICs+MTh method performs noninvasive assessment of NACT response in osteosarcoma that may improve cancer treatment monitoring, planning, and overall prognosis.Key Points• The simple linear iterative clustering supervoxels and Otsu multithresholding-based technique (SLICs+MTh) successfully estimates the proportion of necrosis, viable tumor, and edema in osteosarcoma in the course of chemotherapy.• The proposed technique is noninvasive and uses multiparametric MRI to measure necrosis as an indication of anticancer treatment response.• SLICs+MTh-based necrosis w...
ConclusionsThe e-ASPECTS software generates robust values for e-ASPECTS and acute infarct volumes when using ST ≤ 4 mm with ST = 1 mm yielding the best performance for predicting baseline stroke severity and clinical outcome after 90 days.Key Points•Clinical utility of automatically derived ASPECTS from computed tomography scans was shown in patients with acute ischemic stroke and treatment with mechanical thrombectomy.•Thin slices (= 1 mm) had the highest clinical utility in comparison with thicker slices (2–10 mm) by having the strongest correlation...
Publication date: Available online 25 May 2020Source: Academic RadiologyAuthor(s): Amel Amalou, Baris Turkbey, Sheng Xu, Evrim Turkbey, Peng An, Gianpaolo Carrafiello, Anna Maria Ierardi, Robert Suh, Hayet Amalou, Bradford J. Wood
Publication date: Available online 25 May 2020Source: Pathology - Research and PracticeAuthor(s): Wei Han, Jia Shi, Jiachao Cao, Bo Dong, Wei Guan
Publication date: Available online 5 May 2020Source: Joint Bone SpineAuthor(s): Laure Gossec, Anna Molto, Catherine Beauvais, Eric Senbel, René-Marc Flipo, Sophie Pouplin, Christophe Richez, Alain Saraux, Philippe Gaudin, Daniel Wendling, Maxime Dougados
Publication date: Available online 29 April 2020Source: Joint Bone SpineAuthor(s): Delphine Villeneuve, Olivier Lidove, Pascal Chazerain, Jean-Marc Ziza, Thomas Sené
Publication date: Available online 24 May 2020Source: Neurología (English Edition)Author(s): M. León Ruiz, M. Sospedra, S. Arce Arce, J. Tejeiro-Martínez, J. Benito-León
Publication date: Available online 24 May 2020Source: Neurología (English Edition)Author(s): A.I. Pérez-Álvarez, P. Suárez-Santos, M. González-Delgado, P. Oliva-Nacarino
Publication date: Available online 25 May 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Charmaine Yam, Daniel Merlo, Jim Stankovich, David Darby, Melissa Gresle, Tomas Kalincik, Trevor J Kilpatrick, Jeanette Lechner-Scott, Bruce Taylor, Michael Barnett, Helmut Butzkueven, Anneke van der Walt
More News: Academia | Advertising | Alzheimer's | Anatomy | Austria Health | Biomedical Engineering | Biomedical Science | Bipolar | Brain | Brain Cancers | Brain Tumor | Canada Health | Cardiology | Cerebellum | Computers | Databases & Libraries | Environmental Health | France Health | Geriatrics | Germany Health | Grants | Heart | Ireland Health | Laboratory Medicine | Mania | Medical Ethics | Men | MRI Scan | Multiple Sclerosis | Neurology | Neuroscience | Neurosurgery | New York University | Oxford University | Parkinson's Disease | Perfusion | PET Scan | Psychiatry | Psychology | Rehabilitation | Reproduction Medicine | Respiratory Medicine | Schizophrenia | Science | Statistics | Stroke | Study | Substance Abuse | Substance Abuse Disorders | Training | Universities & Medical Training