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Condition: Hemorrhagic Stroke
Therapy: Statin Therapy

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Total 361 results found since Jan 2013.

Lipids and cerebrovascular disease - New therapeutic options in lowering LDL-cholesterol.
Abstract Stroke is the third most common cause of death worldwide following myocardial infaction and malignancies, furthermore, its functional outcome is the worst of all conditions. Cholesterol, especially LDL-cholesterol plays a key role in the formation of atherosclerotic plaques. It has been verified recently that escalating incidence and mortality of cerebrovascular diseases are proportional to increased levels of LDL-cholesterol. Statin therapy undeniably reduces the risk of stroke, however other methods for decreasing lipid levels have not been proved significantly effective. Preventive effect of high-dose ...
Source: Orvosi Hetilap - November 30, 2016 Category: Journals (General) Authors: Lovadi E, Csécsei P, Lovig C, Karádi Z, Szapáry L Tags: Orv Hetil Source Type: research

Moyamoya Vasculopathy in a Patient with Scleroderma: A Case Report and Review of the Literature (P3.273)
Conclusions:MMS in the context of scleroderma is a very rare entity. The angiographic findings are result of a systemic process at the cellular level, independent of atheromatous changes. They may represent progressive vasculopathy different from the classically described Suzuki stages for moyamoya disease.Disclosure: Dr. Ahmad has nothing to disclose. Dr. Tahir has nothing to disclose. Dr. Mitsias has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ahmad, A., Tahir, R., Mitsias, P. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility
Publication date: Available online 7 October 2017 Source:Pharmacological Research Author(s): Bin Huang, Zhong-Yan Zhou, Shang Li, Xiao-Hui Huang, Jing-Yi Tang, Maggie Pui Man Hoi, Simon Ming Yuen Lee Defects in vascular integrity in cerebrovasculature lead to serious pathologies including hemorrhagic stroke. The stability of cell adhesion junctions and actin-myosin contractile machinery are two major determinants for the integrity of endothelial monolayer. Here we have evaluated the protective effects of tanshinone I (Tan I), a lipophilic compound presents in Salvia miltiorrhiza, against atorvastatin-induced cerebral hemo...
Source: Pharmacological Research - October 8, 2017 Category: Drugs & Pharmacology Source Type: research

Statin Safety: What Every Health Care Provider Needs to Know
AbstractPurpose of ReviewA key target for quality improvement in preventive cardiology is statin therapy, which is underutilized in appropriate high-risk patients for LDL-lowering to prevent atherosclerotic cardiovascular disease events. Translation of statin evidence to practice may be impeded by exaggerated concerns about adverse effects. We aim to cut through an immense amount of controversy in the scientific and mainstream discourse of statin safety by clearly demarcating the reported adverse events based on the reliability of the supporting evidence.Recent FindingsIn large-scale randomized controlled trials, statin th...
Source: Current Cardiovascular Risk Reports - January 22, 2018 Category: Cardiology Source Type: research

Severe Symptoms, but a Truly Treatable Disease
​BY NOURA MAHDI; DARRON LEWIS; JEREMY OSBORNE; & AHMED RAZIUDDIN, MDA 73-year-old man was brought to the emergency department from his nursing home for rectal bleeding and anemia. The patient mentioned he had had episodes of bright red rectal bleeding and constipation for a few months. A colonoscopy had been done prior to the visit, which revealed a large intestine tumor and biopsy confirming adenocarcinoma. He was awaiting an appointment with his surgeon.The patient reported bloody rectal leakage, and a CBC done at the nursing home showed a hemoglobin level of 7.2. He also complained of dyspnea but denied any other ...
Source: The Case Files - March 20, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Lipid Paradox in Statin-Na ïve Acute Ischemic Stroke But Not Hemorrhagic Stroke
Kai-Hung Cheng, Jr-Rung Lin, Craig S. Anderson, Wen-Ter Lai, Tsong-Hai Lee, the SRICHS Group , Tsong-Hai Lee, Yeu-Jhy Chang, Chien-Hung Chang, Hsiu-Chuan Wu, Kuo-Lun Huang, Ting-Yu Chang, Chi-Hung Liu, Chih-Kuang Cheng, Te-Fa Chiu, Chi-Ren Huang, Ho-Fai Wong, Cheng-Hong Toh, Tsung-I Peng, Wen-Yi Huang, Yu-Yi Chien, Kong Chung, Hsiang-Yun Lo, Yao-Liang Chen, Jiann-Der Lee, Meng Lee, Yen-Chu Huang, Shao-Wen Chou, Cheng-Ting Hsiao, Yuan-Hsiung Tsai, Chia-Wei Liou, Ku-Chou Chang, Hung-Sheng Lin, Teng-Yeow Tan, Ru-Huei Fu, Wei Hsi Chen, Chia-Te Kung, Wei-Che Lin
Source: Frontiers in Neurology - August 29, 2018 Category: Neurology Source Type: research

Effects of Statin Therapy on the Risk of Intracerebral Hemorrhage in Korean Patients with Hyperlipidemia
ConclusionStatin therapy was associated with a decreased ICH risk and improvements in ischemic cardiovascular and cerebrovascular outcomes in Korean patients with hyperlipidemia. Further large ‐scale clinical studies are needed to clarify the impact of statins on the risk of developing ICH.This article is protected by copyright. All rights reserved.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 26, 2018 Category: Drugs & Pharmacology Authors: Minji Jung, Sukhyang Lee Tags: Original Research Article Source Type: research

New Biomarkers for Atherothrombosis in Antiphospholipid Syndrome: Genomics and Epigenetics Approaches
Conclusions In recent years, there have been many advances in the understanding of the molecular basis for vascular involvement in APS, but many areas need to be further investigated, in particular the association between altered genetic/epigenetic profiles, autoantibodies and clinical manifestations, and the effectiveness of new therapeutic strategies. It would be interesting to apply next generation sequencing technologies like RNA-Seq along with GWAS to screen both, the gene profile and the whole transcriptome of large cohorts of primary APS patients, in order to reveal the mutations/polymorphisms, post-transcriptiona...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

The impact of statin therapy after surgical or endovascular treatment of cerebral aneurysms.
CONCLUSIONSConsistent statin therapy was significantly associated with better prognosis after coil embolization or surgical clipping of cerebral aneurysms. PMID: 31125972 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - May 23, 2019 Category: Neurosurgery Authors: Song TJ, Oh SH, Kim J Tags: J Neurosurg Source Type: research

Thrombocytopenia and declines in platelet counts: predictors of mortality and outcome after mechanical thrombectomy
ConclusionIn AIS patients treated with MT an initial TP was independently associated with higher mortality rates and a marked DPC with higher mortality rates as well as poorer clinical outcomes.
Source: Journal of Neurology - June 20, 2019 Category: Neurology Source Type: research

The effect of HMG-CoA reductase inhibitors on thrombolysis-induced haemorrhagic transformation
Publication date: Available online 11 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yousheng Wu, Dan Lu, Anding XuAbstractThrombolysis-induced haemorrhagic transformation is the most challenging preventable complication in thrombolytic therapy. This condition is often associated with poor functional outcome and long-term disease burden. Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are controversially suggested to either increase or decrease the odds of better primary outcomes compared to treatment without statins after thrombolysis in patients or animals; statins are ...
Source: Journal of Clinical Neuroscience - September 12, 2019 Category: Neuroscience Source Type: research

Changes of complement and oxidative stress parameters in patients with acute cerebral infarction or cerebral hemorrhage and the clinical significance.
Authors: Zheng M, Wang X, Yang J, Ma S, Wei Y, Liu S Abstract Changes of complement and oxidative stress parameters in patients with acute cerebral infarction (ACI) or cerebral hemorrhage (CH), and their clinical significance were explored. A total of 122 patients with ACI or CH admitted to the People's Hospital of Zhangqiu Area from August 2018 to September 2019 were collected. There were 59 ACI patients assigned into a cerebral infarction group (CIG) and further 63 CH patients in a cerebral hemorrhage group (CHG). Additionally, 53 healthy people in physical examination during the same period were enrolled as a co...
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Mechanism Study of the Protective Effects of Sodium Tanshinone IIA Sulfonate Against Atorvastatin-Induced Cerebral Hemorrhage in Zebrafish: Transcriptome Analysis
This study also provided evidence of biomarkers involved in hemorrhage stroke and improved understanding of the effects of HMG-COA reductase inhibition on vascular permeability and cerebral hemorrhage.
Source: Frontiers in Pharmacology - October 1, 2020 Category: Drugs & Pharmacology Source Type: research