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Condition: Diabetes
Nutrition: Weight Loss

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Total 290 results found since Jan 2013.

Obesity Surgery May Cut Diabetics' Heart Risk
Severely obese patients who had weight-loss surgery were 40 percent less likely to suffer a heart attack or stroke over five years, versus those on standard diabetes care, according to a new study.
Source: WebMD Health - October 16, 2018 Category: Consumer Health News Source Type: news

National Diabetes Month - November 2018.
Authors: Abstract November is National Diabetes Month. In the United States, approximately 30 million persons are living with diabetes and 84 million with prediabetes (1). Persons with prediabetes are at high risk for developing type 2 diabetes, heart disease, and stroke (2). Likewise, women who have had gestational diabetes (diabetes during pregnancy) are at increased risk for developing type 2 diabetes later in life (2). However, type 2 diabetes can be prevented or delayed through a structured lifestyle change program that promotes weight loss, healthy eating, and increased physical activity (2). A report on ch...
Source: MMWR Morb Mortal Wkl... - November 2, 2018 Category: Epidemiology Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitus.
Abstract Patients with type 2 diabetes mellitus (T2DM) exhibit an increased risk for cardiovascular (CV) events. Hyperglycemia itself contributes to the pathogenesis of atherosclerosis and heart failure (HF) in these patients, but glucose-lowering strategies studied to date have had little or no impact on reducing CV risk, especially in patients with a long duration of T2DM and prevalent CV disease (CVD). Sodium-glucose cotransporter-2 (SGLT2) inhibitors are the new class of glucose-lowering medications that increase urinary glucose excretion, thus improving glycemic control, independent of insulin. The recently p...
Source: Indian Heart J - November 1, 2018 Category: Cardiology Authors: Pancholia AK Tags: Indian Heart J Source Type: research

Carbohydrate quality and human health: a series of systematic reviews and meta-analyses
Publication date: Available online 10 January 2019Source: The LancetAuthor(s): Andrew Reynolds, Jim Mann, John Cummings, Nicola Winter, Evelyn Mete, Lisa Te MorengaSummaryBackgroundPrevious systematic reviews and meta-analyses explaining the relationship between carbohydrate quality and health have usually examined a single marker and a limited number of clinical outcomes. We aimed to more precisely quantify the predictive potential of several markers, to determine which markers are most useful, and to establish an evidence base for quantitative recommendations for intakes of dietary fibre.MethodsWe did a series of systema...
Source: The Lancet - January 11, 2019 Category: General Medicine Source Type: research

Role of protein kinase C inhibition in the development of diabetic microvascular complications.
Authors: Skljarevski V, Ferdinand SJ, Kles KA Abstract Diabetes mellitus affects millions of people in the USA and throughout the world. The global epidemic may be attributed to both the increasing age of the population and the increasing rates of obesity. Diabetes is associated with chronic microvascular (diabetic neuropathy, retinopathy and nephropathy) and macrovascular complications (heart disease, stroke and peripheral vascular disease). Patients with diabetes benefit from a comprehensive approach to prevent complications, including weight loss, smoking cessation, antiplatelet agents, and glycemic and blood pr...
Source: Expert Review of Endocrinology and Metabolism - February 15, 2019 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

The Discovery and Development of Liraglutide and Semaglutide
We describe one such approach, albumin binding, and explain how it was applied in the development of the human GLP-1 analog liraglutide once daily and, subsequently, semaglutide once weekly. The pharmacology of these two long-acting GLP-1 analogs, in terms of improving glycemic control, reducing body weight and decreasing cardiovascular (CV) risk, is also reviewed, together with some novel biology. In addition, we describe the importance of accurate target (GLP-1 receptor) tissue expression analysis. Now an established class of agents, GLP-1-based therapies represent a significant advance in the treatment of T2D. All curr...
Source: Frontiers in Endocrinology - April 11, 2019 Category: Endocrinology Source Type: research

Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

Liraglutide for the prevention of major adverse cardiovascular events in diabetic patients.
Authors: Madsbad S Abstract INTRODUCTION: The GLP-1 receptor agonist (GLP-1 RA) liraglutide has a half-life of approximately 13 h and is suitable for subcutaneous administration once daily. The use of liraglutide in people with type 2 diabetes has become popular because of the efficacy and durability in relation to glycemic control in combination with weight loss in most patients. Areas covered: PubMed searches were completed using the terms "GLP-1 receptor agonist", "Liraglutide", "Liraglutide and CVD", "Liraglutide and CVD risk factors". The reference list of articles subsequently identified was searched and arti...
Source: Expert Review of Cardiovascular Therapy - May 7, 2019 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditure
ConclusionWe propose PRIP as a new therapeutic target for controlling obesity or developing novel anti-obesity drugs.
Source: Journal of Oral Biosciences - May 16, 2019 Category: Biomedical Science Source Type: research

Macro- and micro-vascular complications and their determinants among people with type 2 diabetes in Bangladesh
ConclusionDiabetes complications are highly prevalent among type 2 diabetes population in Bangladesh. Prevention strategies should focus on increasing physical activity, weight loss, smoking cessation, and more strict control of hypertension and glycaemic level.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - August 1, 2019 Category: Endocrinology Source Type: research

Weight-Loss Surgery May Reduce Heart Risks in People With Type 2 Diabetes
A review of patient records finds startling differences, but critics say a clinical trial must be done.
Source: NYT Health - September 2, 2019 Category: Consumer Health News Authors: Roni Caryn Rabin Tags: Bariatric Surgery Diabetes Obesity Weight Heart Stroke Cleveland Clinic Journal of the American Medical Assn Nissen, Steven E Surgery and Surgeons your-feed-science United States Medtronic Inc Source Type: news

Monthly Lifestyle Counseling Tied to Better Outcomes for Patients with Diabetes
In a real-world study of patients with diabetes, those who received counseling about exercise, diet and weight loss at least once a month had lower risk of stroke, heart attacks and death than those who did not
Source: BWH News - August 1, 2019 Category: Hospital Management Source Type: news

Pharmacological treatment of NASH.
Abstract Lifestyle modifications, especially weight loss, are efficient on NASH liver injury, however rarely followed in clinical practice. The target population of pharmacologic treatments is represented by patients with NASH and fibrosis. Out of histological improvement, efficacy of treatments should be assessed through liver morbi-mortality benefit, but also on extrahepatic events, such as cardiovascular. Among anti-diabetic treatments, glitazones et GLP-1 agonists have shown efficacy on histological liver injury. Vitamin E is efficient on liver injury but at the cost of prostate cancer and stroke over risk. Ab...
Source: Presse Medicale - November 18, 2019 Category: General Medicine Authors: Serfaty L Tags: Presse Med Source Type: research

History of Cardiovascular Disease, Intensive Lifestyle Intervention, and Cardiovascular Outcomes in the Look AHEAD Trial.
CONCLUSIONS: Intervention response heterogeneity was significant for nonfatal MI. Response heterogeneity may need consideration in a CVD-outcome trial design. PMID: 31898874 [PubMed - as supplied by publisher]
Source: Obesity - January 2, 2020 Category: Eating Disorders & Weight Management Authors: Look AHEAD Research Group, Lewis CE, Bantle JP, Bertoni AG, Blackburn G, Brancati FL, Bray GA, Cheskin LJ, Curtis JM, Egan C, Evans M, Foreyt JP, Ghazarian S, Barone Gibbs B, Glasser SP, W Gregg E, Hazuda HP, Hesson L, Hill JO, Horton ES, Hubbard VS, Jaki Tags: Obesity (Silver Spring) Source Type: research