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Total 374 results found since Jan 2013.

Why is Clinical fMRI in a Resting State?
Conclusions Despite some perceived impediments to expanding clinical rs-fMRI use, neuroradiologists were generally enthusiastic about rs-fMRI in research and clinical applications, believing that their current workplace MRI systems are suitable for rs-fMRI acquisition. Many of the concerns associated with using rs-fMRI in clinical contexts are related to: (1) developing better methods for minimizing physiological noise effects, (2) improving methods for detecting the spatial characteristics of clinically-relevant brain processing systems in individual patients, and (3) overcoming remaining standardization, training, and r...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Glutamate Transport and Preterm Brain Injury
Silvia Pregnolato1*, Elavazhagan Chakkarapani1, Anthony R. Isles2 and Karen Luyt1 1Department of Neonatal Neurology, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom 2Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom Preterm birth complications are the leading cause of child death worldwide and a top global health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral palsy and impairment of movement, cognition, and beh...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Anxiety in Patients With Acute Ischemic Stroke: Risk Factors and Effects on Functional Status
Conclusion: Depressive symptoms are the major correlates of PSA while more severe PSA is associated with poorer ADL and health-related QOL. Acute lesions involving CHWM may correlate with PSA in ischemic stroke patients with mild-to-moderate neurologic deficits, supporting a lesion-location hypothesis in PSA.IntroductionAnxiety is prevalent after stroke and occurs in about one-quarter of stroke survivors (1, 2). Poststroke anxiety (PSA) may have a negative impact on quality of life (QOL) of stroke survivors, affecting their rehabilitation (3). Furthermore, one prospective study found that severe anxiety symptoms were assoc...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

Functional MRI of Letter Cancellation Task Performance in Older Adults
Conclusion The present work is the first to identify neural correlates of the LCT using fMRI and tablet technology in a healthy aging population. Across all ages, the activation was found to be bilateral, including in the cerebellum, superior temporal lobe, precentral gyrus, frontal gyrus, and various occipital and parietal areas. With increasing age, performance generally decreased and brain activity was reduced in the supplementary motor area, middle and inferior frontal gyrus, middle occipital gyrus, putamen and cerebellum. Better LCT performance was correlated with increased activity in the middle frontal gyrus, and r...
Source: Frontiers in Human Neuroscience - April 15, 2019 Category: Neuroscience Source Type: research

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Early Prophylactic Hypothermia for Patients With Severe Traumatic Injury: Premature to Close the Case
This study demonstrates that there is no role for the initiation of hypothermia during the acute phase of TBI (1, 2). However, it would be damaging to abandon the concept prematurely. Inflammation Also Paves the Way to Tissue Repair As soon as trauma occurs, the inflammatory cascade begins to take place. The deleterious role of inflammation in the secondary injury response is well-documented, hence the rationale to attempt early prophylactic hypothermia in TBI. However, inflammation also initiates tissue repair and regeneration (3–6). We now know that the secondary injury response accompanies the regenerating and...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

How cost-effective is intraoperative MRI for gliomas?
Using a simulated clinical decision analysis model, researchers from the University...Read more on AuntMinnie.comRelated Reading: Workflow optimization cuts MRI turnaround time Imaging analytics platform optimizes MRI operations MRA is cost-effective for kidney disease-related aneurysms Study reveals steep cost of delaying stroke treatment MRI for knee pain adds cost with negligible benefit
Source: AuntMinnie.com Headlines - April 2, 2019 Category: Radiology Source Type: news

Surgical Management of Deep-Seated Metastatic Brain Tumors Using Minimally Invasive Approaches
Conclusion This minimally invasive approach can be used to achieve extensive resection with minimal morbidity for arguably the highest risk metastatic brain tumors. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - March 19, 2019 Category: Neurosurgery Authors: Gassie, Kelly Alvarado-Estrada, Keila Bechtle, Perry Chaichana, Kaisorn L. Tags: Original Article Source Type: research

Depressive symptoms across the age span: findings from an integrated epilepsy self-management clinical studies dataset.
Epilepsy has been reported by the CDC to have a prevalence of 1.2% in the United States, which accounts for roughly 3.4 million adults in 2015. Nearly 1 million of those adults are aged 55 or older.1 Epilepsy is more likely to develop in older adults because risk factors for epilepsy are more common as people age including stroke/cardiovascular disease, neurodegenerative disorders, brain tumor and long-term sequelae of alcohol abuse.2 As our population ages, there will be even more older people with epilepsy.
Source: The American Journal of Geriatric Psychiatry - February 28, 2019 Category: Geriatrics Authors: Zaira Khalid, Hasina Momotaz, Kristen Cassidy, Naomi Chaytor, Robert Fraser, Mary Janevic, Barbara Jobst, Erica Johnson, Peter Scal, Tanya Spruill, Martha Sajatovic Tags: Poster Number: EI - 9 Source Type: research

Parkinson's patients have tubes placed in brain in protein study
New drug-delivery system could also be used to treat brain tumours and strokesPeople with Parkinson ’s disease have been fitted with an implant that can deliver drugs directly to the brain through a port in the side of their head, in a pioneering study.The device was used to send a naturally occurring protein, which it is hoped may help restore cells damaged by the disease, to an affected part of the brain.Continue reading...
Source: Guardian Unlimited Science - February 27, 2019 Category: Science Authors: Press Association Tags: Parkinson's disease Stroke Medical research Science Society UK news Neuroscience Source Type: news

Study unveils a blueprint for treating a deadly brain tumor
(NIH/National Institute of Neurological Disorders and Stroke) In a study of mice and human brain tumors researchers at the University of the Michigan, Ann Arbor, searched for new treatments by exploring the reasons why some patients with gliomas live remarkably longer than others. The results suggested that certain patients' tumor cells are less aggressive and much better at repairing DNA than others but are difficult to kill with radiation. The researchers then showed that combining radiation therapy with cancer drugs designed to block DNA repair may be an effective treatment strategy.
Source: EurekAlert! - Cancer - February 19, 2019 Category: Cancer & Oncology Source Type: news

Protective Effects of Alpha-Lipoic Acid on Glutamate-Induced Cytotoxicity in C6 Glioma Cells.
In this study, we investigated the protective effects of alpha-lipoic acid (ALA), a naturally occurring thiol antioxidant, on glutamate-induced cytotoxicity in cultured C6 astroglial cells. Exposure to high-dose glutamate (10 mM) caused oxidative stress and mitochondrial dysfunction through the elevation of reactive oxygen species, depletion of glutathione, and loss of the mitochondrial membrane potential (ΔΨm). Pretreatment with ALA (200 µM), however, significantly inhibited the glutamate-induced oxidative stress and mitochondrial dysfunction. ALA pretreatment dose-dependently suppressed glutamate-induced apoptotic...
Source: Biological and Pharmaceutical Bulletin - January 6, 2019 Category: Drugs & Pharmacology Authors: Park E, Gim J, Kim DK, Kim CS, Chun HS Tags: Biol Pharm Bull Source Type: research

Applications of nanotechnology in drug delivery to the central nervous system
This study was conducted to review the evidence on the applications of nanotechnology in designing drug delivery systems with the ability to cross through the blood-brain barrier (BBB) in order to transfer the therapeutic agents to the CNS.
Source: Biomedicine and Pharmacotherapy - January 4, 2019 Category: Drugs & Pharmacology Source Type: research

Applications of nanotechnology in drug delivery to the central nervous system.
This study was conducted to review the evidence on the applications of nanotechnology in designing drug delivery systems with the ability to cross through the blood-brain barrier (BBB) in order to transfer the therapeutic agents to the CNS. PMID: 30611991 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 3, 2019 Category: Drugs & Pharmacology Authors: Saeedi M, Eslamifar M, Khezri K, Dizaj SM Tags: Biomed Pharmacother Source Type: research