Why is Clinical fMRI in a Resting State?

In conclusion, while rs-fMRI use in clinical neuroradiology practice is limited, enthusiasm appears to be quite high and there are several possible avenues in which further research and development may facilitate its penetration into clinical practice. Introduction Techniques for quantifying spatial and temporal brain activity have developed rapidly since the first demonstrations that MRI could be used to measure modulations in blood oxygen level dependent (BOLD) tissue contrast (1). The observation that MRI could be used to monitor temporally correlated low-frequency activity fluctuations in spatially remote brain areas led to widespread use of resting state functional magnetic resonance imaging (rs-fMRI) to evaluate resting state network (RSN) properties. While BOLD-contrast is an indirect measure of neural activity, similar inter-regional coherent spontaneous neural activity correlations have been observed with electrophysiological techniques (2), suggesting that rs-fMRI networks can provide useful information about the macroscopic organization of neural processing systems. The methods and possible uses of rs-fMRI have recently been reviewed (3, 4). Establishing that rs-fMRI can identify spontaneous brain activity patterns resembling those seen with tasks (5) has led to its widespread acceptance, and a rapid expansion in rs-fMRI publications. Nearly 10,000 rs-fMRI papers are currently listed in PubMed. The most rapidly developing type of functional connectivity rese...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Hearthside Food Solutions of Woodridge, IL is voluntarily recalling 7-Eleven ‘The Italian Job’ sandwiches, which have an incorrect information panel label that does not declare eggs as an allergen. Persons who have an allergy or severe sensitivity to eggs run the risk of serious or life-threatening
Source: FDA Food Alergies - Category: Food Science Authors: Source Type: alerts
Authors: Oh MY, Kim KE, Kim MJ, Chu A, Lee JY, Park JH, Kim J, Hwang KT Abstract Sparganosis is a parasitic infestation caused by sparganum, a plerocercoid tapeworm larva of the genus Spirometra. Since the first case of human sparganosis reported in 1908, sparganosis has been a global disease, and is common in China, Japan, and Southeast Asian countries. Consumption of raw snakes, frogs, fish, or drinking contaminated beverages are sources of human infections. Human sparganosis usually manifests in subcutaneous fat in areas such as the abdomen, genitourinary tract, and limbs. Breast sparganosis cases are rare, repr...
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
In this study, prevalence of CE and variation of cox1 gene sequence were analyzed with isolates E. granulosus collected from different areas in northern Xinjiang, China. The survey showed that 3.5% of sheep and 4.1% of cattle were infected with CE. Fragment of cox1 was amplified from all the positive sheep and cattle samples by PCR. In addition, 26 positive samples across the 4 areas were included. The isolates were all E. granulosus sensu stricto (s.s.) containing 15 haplotypes (Hap1-15), and clustered into 2 genotypes, G1 (90.1%, 91/101) and G3 (9.9%, 10/101). Hap1 was the most common haplotype (48.5%, 49/101). Hap9 were...
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
Authors: Shin SP, Jin CN, Sohn HC, Lee J Abstract Sinuolinea capsularis Davis, 1917 is myxosporean that infect the urinary system of the host fish. Insufficient morphological and molecular data of S. capsularis exits, and it is therefore difficult to make an accurate identification of the parasite. We tried a series of morphological and molecular analysis to identify an myxosporean isolated from urinary bladder of cultured olive flounder, Paralichthys olivaceus, from Jeju island in the Republic of Korea. Some of them were observed under a light microscope and SEM, and remain samples were used molecular and phylogen...
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
Authors: Meade KJ, Sanchez F, Aguayo A, Nadales N, Hamalian SG, Uhlendorf TL, Banner LR, Kelber JA Abstract Cancer metastasis is responsible for the clear majority of cancer-related deaths. Survival and expansion of cancer cells at secondary sites requires that these premetastatic microenvironments be primed by primary tumor cells and their secreted factors. Efforts to date have been limited by immune-deficient in vivo models and/or the need for finely-tuned analysis time points that reduce contributions from early-disseminating cancer cells. In this regard, we developed a tumor cell-free syngeneic breast cancer mo...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusion: In conclusion, the proposed motion correction method showed good results in phantom data and a promising reduction of detected lesion volume and a consequently increasing activity uptake in three patients with lung lesions. PMID: 31105880 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Huang T, Garcia R, Qi J, Lulla R, Horbinski C, Behdad A, Wadhwani N, Shilatifard A, James C, Saratsis AM Abstract [This corrects the article DOI: 10.18632/oncotarget.26430.]. PMID: 31105875 [PubMed - in process]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Publication date: Available online 21 May 2019Source: Parasitology InternationalAuthor(s): Tran Nhat Thang, Hakimullah Hakim, Raihana Royan Rahimi, Madoka Ichikawa-SekiAbstractRecently, phosphoenol pyruvate carboxykinase (pepck) and DNA polymerase delta (pold) were established as reliable nuclear markers for species identification of Fasciola spp. in multiplex polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism-based assays, respectively. Currently, little is known about Fasciola species distribution in Central Asia. Therefore, the objective of the present study was to perform precise molecular...
Source: Parasitology International - Category: Parasitology Source Type: research
Authors: Ma S, Adjavon S, Bouchiha N, Castelli C, Fischler M, Mellot F, Le Guen M Abstract BACKGROUND: A thoracic computed tomography scan is rarely used to help choose the appropriate double-lumen tube. Nowadays, bronchial measurements can be automated using dedicated software. The aim of this prospective monocentric study was to compare manual and automated measurements of the diameter of the trachea and both main bronchi in adult patients free from a history of lung surgery or disease. METHODS: Diameters of the trachea and of the main stem bronchi were measured by trained physicians or automatically using Th...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
In this study, we compared facial emotion recognition performance in age- and gender-matched schizophrenia spectrum disorders subjects with (N = 52) and without (N = 52) a history of violence. Data on current symptom severity, Cluster B personality status, past victimization, and alcohol and substance misuse were also collected. Compared to those without, subjects with a history of violence showed worse facial emotion recognition performances, involving anger, fear, disgust, sadness, and happiness. When formally testing the reporting of angry faces, evidence of enhanced sensitivity to anger was ...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
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