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Condition: Dementia
Drug: Insulin

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Total 47 results found since Jan 2013.

Cochrane Priority Reviews List: December 2016 Update
Cochrane-wide prioritisation remains an important project, with over 140 priority reviews or updates have been published since it began in January 2015.The December 2016 revision of the Cochrane Priority Reviews List includes new titles from the Cochrane Airways, Anaesthesia, Dementia& Cognitive Improvement, ENT, Epilepsy, Gynaecological, Neuro-oncology and Orphan Cancers, Gynaecology& Fertility, Haematological Malignancies, Heart, Incontinence, Kidney& Transplant, Lung Cancer, Neuromuscular Disease, Oral Health, Skin, Stroke, and Urology Groups.The following titles on the list are open to new authors:Long-acti...
Source: Cochrane News and Events - December 14, 2016 Category: Information Technology Authors: mumoquit at cochrane.org Source Type: news

7 Tips To Lower Diabetes Risk in Menopause During the Holidays
By now, most people have been to a holiday party or two. Lots of food, lots of eggnog and other carb laden alcoholic beverages, and lots of grazing all day long on all the boxes of candy friends and business acquaintances sent to us. It's easy to gain the five pounds most people gain during the holidays, and in the process, raise your blood sugar or glucose levels too high. That's your body letting you know you have prediabetes (higher than normal but still below diabetes levels) or diabetes, and unless you take action soon, your body won't like it. Diabetes silently sneaks up on you and if untreated, slowly weakens your ...
Source: Healthy Living - The Huffington Post - December 23, 2016 Category: Consumer Health News Source Type: news

Glycemic control and disability ‐free survival in hypoglycemic agent‐treated community‐dwelling older patients with type 2 diabetes mellitus
ConclusionsThese observations show that a too low HbA1c might be associated with a later risk of incident disability as a result of dementia in community‐dwelling older diabetes patients. Geriatr Gerontol Int 2017; •••: ••–••.
Source: Geriatrics and Gerontology International - February 10, 2017 Category: Geriatrics Authors: Takuro Morita, Tazuo Okuno, Taroh Himeno, Keisuke Watanabe, Kumie Nakajima, Yumi Koizumi, Hiroshi Yano, Osamu Iritani, Masashi Okuro, Shigeto Morimoto Tags: Original Article: Epidemiology, Clinical Practice and Health Source Type: research

Truth, And The Tribulations Of Randomized Diet Trials
This study has not been done. This study will not be done. Whatever you do, don’t hold your breath waiting for it.But, so what?Let’s contrast our ostensible need for this RCT to how we know what we know about putting out house fires.First, there has never been, to the best of my knowledge, a RCT to show that water is a better choice than gasoline. Do you think we need such a trial, to establish the legitimacy of the basic theme (i.e., use water) of the “right” approach? Would you, and your home, be willing to participate in such a trial when you call 911- knowing you might randomly be assigned to the gasoline a...
Source: Healthy Living - The Huffington Post - February 17, 2017 Category: Consumer Health News Source Type: news

Continuous glucose monitoring reveals hypoglycemia risk in elderly patients with type 2 diabetes mellitus
ConclusionsIn patients aged ≥65 years with type 2 diabetes, higher glucose variability and lower average glucose levels indicate a greater hypoglycemia risk. It is therefore necessary to ensure comprehensive blood glucose control in such patients to prevent hypoglycemia.This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - March 1, 2017 Category: Endocrinology Authors: Takahiro Ishikawa, Masaya Koshizaka, Yoshiro Maezawa, Minoru Takemoto, Yoshiharu Tokuyama, Toshihiro Saito, Koutaro Yokote Tags: Original Article Source Type: research

How The GOP's Health Plan Shifts The Burden To Family Caregivers
There are two words missing in the 100-plus pages of the American Health Care Act, which narrowly passed the House on Thursday without a single Democratic vote: “family caregivers.” It’s a shame, because the trickle-down effects of the bill ― should it pass the Senate ― would swell the ranks of the nation’s 43.5 million unpaid and untrained family members who sacrifice portions of their own lives and livelihoods to spare their loved ones being kicked to the curb. Many aspects of the Obamacare repeal uniquely target older Americans. But there’s one in particular that threatens to ...
Source: Healthy Living - The Huffington Post - May 5, 2017 Category: Consumer Health News Source Type: news

Brain microvascular injury and white matter disease provoked by diabetes ‐associated hyperamylinemia
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - June 1, 2017 Category: Neurology Authors: Han Ly, Nirmal Verma, Fengen Wu, Miao Liu, Kathryn E. Saatman, Peter T. Nelson, John T. Slevin, Larry B. Goldstein, Geert Jan Biessels, Florin Despa Tags: Research Article Source Type: research

Insulin resistance among obese middle-aged is associated with decreased cerebrovascular reactivity
Conclusions: IR is associated with impaired CVR; the relationship appears to be driven by the degree of IR and not by obesity. These rarely reported results suggest that early forms of cerebrovascular dysfunction exist among obese middle-aged individuals with significant IR but without type 2 diabetes mellitus. These functional vascular abnormalities may help explain the associations among IR, diabetes, and dementia, and suggest that interventions aiming to improve IR or CVR may help prevent cognitive decline later in life.
Source: Neurology - July 17, 2017 Category: Neurology Authors: Frosch, O. H., Yau, P. L., Osorio, R. S., Rusinek, H., Storey, P., Convit, A. Tags: MRI, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Curative treatment of hypertension by physical exercise.
Authors: Lou M, Zong XF, Wang LL Abstract Hypertension, one of the most common chronic and sporadic conditions, figures among the important worldwide public-health challenges, and it is a major risk for heart disease, stroke, kidney disease and other complications, including dementia. Hypertension is neglected by individuals, and the prevalence of this condition continues to rise across the world. A great number of patients receiving medical intervention is not successfully treated, while adequate curative health services are dependent on the exact update data of the countrywide prevalence of known and undetected c...
Source: European Review for Medical and Pharmacological Sciences - August 6, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Two Liters a Day Keep the Doctor Away? Considerations on the Pathophysiology of Suboptimal Fluid Intake in the Common Population
Suboptimal fluid intake may require enhanced release of antidiuretic hormone (ADH) or vasopressin for the maintenance of adequate hydration. Enhanced copeptin levels (reflecting enhanced vasopressin levels) in 25% of the common population are associated with enhanced risk of metabolic syndrome with abdominal obesity, type 2 diabetes, hypertension, coronary artery disease, heart failure, vascular dementia, cognitive impairment, microalbuminuria, chronic kidney disease, inflammatory bowel disease, cancer, and premature mortality. Vasopressin stimulates the release of glucocorticoids which in turn up-regulate the serum- and g...
Source: Kidney and Blood Pressure Research - August 8, 2017 Category: Urology & Nephrology Source Type: research

Oral antidiabetic drugs and dementia risk: Does treatment matter?
As the population ages, dementia grows as a public health problem. The rising life expectancy and the aging of the so-called baby boomer cohort translate to a substantial number of people reaching ages of high risk for age-related conditions like dementia. As a major cause of disability and dependency in elderly people, dementia puts social and economic burden on patients and their families and affects health care systems worldwide. In the absence of a cure, primary prevention will have the largest effect on the reduction of dementia occurrence.1 Thus, public health research should focus on the identification of modifiable...
Source: Neurology - October 30, 2017 Category: Neurology Authors: Fink, A., Haenisch, B. Tags: All Cognitive Disorders/Dementia, All epidemiology EDITORIALS Source Type: research

Molecules, Vol. 23, Pages 258: Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation
ury Hossain Diabetes is associated with obesity, generally accompanied by a chronic state of oxidative stress and redox imbalances which are implicated in the progression of micro- and macro-complications like heart disease, stroke, dementia, cancer, kidney failure and blindness. All these complications rise primarily due to consistent high blood glucose levels. Insulin and glucagon help to maintain the homeostasis of glucose and lipids through signaling cascades. Pancreatic hormones stimulate translocation of the glucose transporter isoform 4 (GLUT4) from an intracellular location to the cell surface and facilitate th...
Source: Molecules - January 28, 2018 Category: Chemistry Authors: Abu Sayem Aditya Arya Hamed Karimian Narendiran Krishnasamy Ameya Ashok Hasamnis Chowdhury Hossain Tags: Review Source Type: research

Diabetes in the older patient: heterogeneity requires individualisation of therapeutic strategies
AbstractOwing to the worldwide increase in life expectancy, the high incidence of diabetes in older individuals and the improved survival of people with diabetes, about one-third of all individuals with diabetes are now older than 65  years. Evidence is accumulating that type 2 diabetes is associated with cognitive impairment, dementia and frailty. Older people with diabetes have significantly more comorbidities, such as myocardial infarction, stroke, peripheral arterial disease and renal impairment, compared with those without diabetes. However, as a consequence of the increased use of multifactorial risk factor interven...
Source: Diabetologia - June 4, 2018 Category: Endocrinology Source Type: research

Management of hypoglycemia in older adults with type 2 diabetes.
This article highlights the issues faced by older people with T2D, the risk factors for hypoglycemia in this population, and the challenges faced by health care providers regarding glycemic management in this patient group. PMID: 30724638 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - February 8, 2019 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway
Conclusion The data in this manuscript demonstrates that apelin-13 upregulates BDNF against STZ-induced congnitive impairment by suppressing glial cell activity and inflammatory factors release. This suggests apelin signaling may be a new target in the treatment of AD. Ethics Statement All experimental protocols were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals approved by the Central South University at XiangYa Animal Care and Use Committee. Author Contributions XqQ and LH conceived the study and contributed to its experimental design. HqL carried out the...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research