Molecules, Vol. 23, Pages 258: Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation
Molecules, Vol. 23, Pages 258: Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation
Molecules doi: 10.3390/molecules23020258
Authors:
Abu Sayem
Aditya Arya
Hamed Karimian
Narendiran Krishnasamy
Ameya Ashok Hasamnis
Chowdhury Hossain
Diabetes is associated with obesity, generally accompanied by a chronic state of oxidative stress and redox imbalances which are implicated in the progression of micro- and macro-complications like heart disease, stroke, dementia, cancer, kidney failure and blindness. All these complications rise primarily due to consistent high blood glucose levels. Insulin and glucagon help to maintain the homeostasis of glucose and lipids through signaling cascades. Pancreatic hormones stimulate translocation of the glucose transporter isoform 4 (GLUT4) from an intracellular location to the cell surface and facilitate the rapid insulin-dependent storage of glucose in muscle and fat cells. Malfunction in glucose uptake mechanisms, primarily contribute to insulin resistance in type 2 diabetes. Plant secondary metabolites, commonly known as phytochemicals, are reported to have great benefits in the management of type 2 diabetes. The role of phytochemicals and their action on insulin signaling pathways through stimulation of GLUT4 translocation is crucial to understand the pathogenesis of this disease in the management process. This review will summarize the effects of phytochemicals...
Source: Molecules - Category: Chemistry Authors: Abu Sayem Aditya Arya Hamed Karimian Narendiran Krishnasamy Ameya Ashok Hasamnis Chowdhury Hossain Tags: Review Source Type: research
More News: Blindness | Cancer | Cancer & Oncology | Cardiology | Dementia | Diabetes | Diabetes Type 2 | Eating Disorders & Weight Management | Endocrinology | Heart | Heart Disease | Hormones | Insulin | Obesity | Opthalmology | Pancreas | Pancreatic Cancer | Stroke | Translocation | Urology & Nephrology