Oral antidiabetic drugs and dementia risk: Does treatment matter?

As the population ages, dementia grows as a public health problem. The rising life expectancy and the aging of the so-called baby boomer cohort translate to a substantial number of people reaching ages of high risk for age-related conditions like dementia. As a major cause of disability and dependency in elderly people, dementia puts social and economic burden on patients and their families and affects health care systems worldwide. In the absence of a cure, primary prevention will have the largest effect on the reduction of dementia occurrence.1 Thus, public health research should focus on the identification of modifiable risk factors for dementia. Diabetes mellitus is an established risk factor for dementia. Patients with diabetes have an increased risk for any dementia, Alzheimer disease, and vascular dementia.2 The exact mechanisms of cognitive impairment in diabetic patients remain unknown. The main contributors to diabetes-associated cognitive decline include hyperglycemia, decreased insulin secretion, obesity, increased oxidative stress, and inflammation.3 Diabetes not only promotes neurodegeneration but also induces cerebrovascular pathologies such as stroke, which in turn are further risk factors for dementia.4 Furthermore, patients with diabetes often have other comorbidities such as high blood pressure and cardiovascular disease that may contribute to the development of dementia. About 12%–14% of US adults have diabetes.5 An effective treatment could prevent ...
Source: Neurology - Category: Neurology Authors: Tags: All Cognitive Disorders/Dementia, All epidemiology EDITORIALS Source Type: research

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Publication date: Available online 10 July 2020Source: International Review of NeurobiologyAuthor(s): Russell H. Swerdlow
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 10 July 2020Source: International Review of NeurobiologyAuthor(s): Mark P. Mattson
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 9 July 2020Source: Obesity Research &Clinical PracticeAuthor(s): Abdulzahra Hussain, Kamal Mahawar, Zefeng Xia, Wah Yang, Shamsi EL-Hasani
Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
Publication date: Available online 10 July 2020Source: Food ChemistryAuthor(s): Ting Xia, Wenhui Duan, Zhujun Zhang, Bin Fang, Bo Zhang, Bicheng Xu, Celia Bertha Vargas de la Cruz, Hesham El-Seedi, Jesus Simal-Gandara, Shaoyun Wang, Min Wang, Jianbo Xiao
Source: Food Chemistry - Category: Food Science Source Type: research
This study used 30 adult male mice strain BALB/c. Diabetes was induced using high-fat diet/streptozotocin method until random blood glucose level reached> 200 mg/dL. Diabetic mice were then exposed to electrical field (static and dynamic), magnetic field (static and induce), and infrared ray (with or without infrared ray) combination therapy 15 min daily for 28 days. Fasting blood glucose level, plasma insulin level, HOMA-IR index, and membrane GLUT-4 density after treatment were analyzed statistically atα = 0.05. Result showed that exposure combination of electrical field, magnetic field, and infrared were found ...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
The objective of this study was investigating the additional effect of DL with nonsurgical periodontal treatment on the red complex bacteria in type 2 diabetes mellitus (DM) patients with chronic periodontitis (CP). Sixty type 2 DM patients with chronic periodontitis (CP) were randomly assigned in two parallel groups to receive scaling root planning (SRP,n = 30) or SRP followed by DL periodontal pocket irradiation (SRP + DL,n = 30). Recording of clinical parameters and subgingival plaque sampling were performed at baseline, and post therapy (1 and 3 months after treatment). Amounts ofPorphy...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
This study presents the effects of berberine (BBR) on the aging process resulting in a promising extension of lifespan in model organisms. BBR extended the replicative lifespan, improved the morphology, and boosted rejuvenation markers of replicative senescence in human fetal lung diploid fibroblasts. BBR also rescued senescent cells with late population doubling (PD). Furthermore, the senescence-associated β-galactosidase (SA-β-gal)-positive cell rates of late PD cells grown in the BBR-containing medium were ~72% lower than those of control cells, and its morphology resembled that of young cells. Mechanistically...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions: Lifestyle factors, such as physical activity, sleep, and social activity appear to be associated with cognitive function among older people. Physical activity and appropriate durations of sleep and conversation are important for cognitive function. Introduction Dementia is a major public health issue worldwide, with a serious burden for patients, caregivers, and society, as well as substantial economic impacts (1). Although the prevalence of late-life cognitive impairment and dementia are expected to increase in future, effective disease-modifying treatments are currently unavailable. Therefore, unders...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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