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Condition: Liver Disease

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Association of injection drug use with incidence of HIV-associated non-AIDS-related morbidity by age, 1995–2014
Conclusion: Not all HANA comorbidities occur with higher incidence in PWID compared with non-IDU. However, higher incidence of ESRD and ESLD among PWIDs highlights the importance of recognition and management of markers of these comorbidities in early stages among PWID.
Source: AIDS - May 13, 2016 Category: Infectious Diseases Tags: Epidemiology and Social Source Type: research

Coffee 'cuts risk of dying from heart disease' – video
Research has found that drinking three or more cups of coffee a day can cut the risk of dying early by between 8% and 18%. Scientists suggest drinking coffee lowers the risk of dying from a host of causes, including heart disease, stroke and liver disease. However, experts say it is unclear whether the health boost is down to the brew itself.Coffee cuts risk of dying from stroke and heart disease, study suggestsContinue reading...
Source: Guardian Unlimited Science - July 11, 2017 Category: Science Authors: Guardian Staff Tags: Coffee Food & drink UK news Culture Life and style Health Medical research Science Source Type: news

Real-world Data and Recommended Dosage of Non-vitamin K Oral Anticoagulants for Korean Patients.
Authors: Joung B Abstract Regulatory approvals of non-vitamin K antagonist oral anticoagulants (NOACs) have been based on large randomized phase III trials evaluating dabigatran, rivaroxaban, apixaban, or edoxaban relative to warfarin for atrial fibrillation (AF). The results of the trials showed that all NOACs were at least non-inferior to warfarin in the prevention of stroke/thromboembolism and showed lower rates of intracranial bleeding than those associated with warfarin. However, the trials were designed differently, varied in the inclusion/exclusion criteria, and used either one dose or a low/high dose of the...
Source: Korean Circulation Journal - November 26, 2017 Category: Cardiology Tags: Korean Circ J Source Type: research

The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation
AbstractThe current manuscript is the second update of the original Practical Guide, published in 2013 [Heidbuchelet al. European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation.Europace 2013;15:625 –651; Heidbuchelet al. Updated European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist anticoagulants in patients with non-valvular atrial fibrillation. Europace 2015;17:1467 –1507]. Non-vitamin K antagonist oral anticoagulants (NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in pati...
Source: European Heart Journal - March 19, 2018 Category: Cardiology Source Type: research

The Emergence of Non-communicable Disease in Indonesia.
Authors: Purnamasari D Abstract Based on data from the Indonesian Ministry of Health Information Center, the estimated population of Indonesia in 2016 was approximately 258,704,986 people, consisted of 129,988,690 men and 128,716,296 women. This number of Indonesian population represents young population since the proportion of population aged 0-14 years is more than that aged >14 years. Meanwhile, the proportion of population aged 50 years and above is significantly reduced, which is thought to be due to high mortality rate in the middle-aged population. The mortality rate in  Indonesia is dominated by non-com...
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Transcriptomic Analysis of Mecp2 Mutant Mice Reveals Differentially Expressed Genes and Altered Mechanisms in Both Blood and Brain
This study was carried out in accordance with the recommendations of National Animal Welfare Authority, Ireland. The protocol was approved by the Animal Ethical Committee Trinity College Dublin and HPRA.Author ContributionsAS performed the experiments and wrote the paper; KH provided assistance in the design and analysis of the RNAseq experiment; DT contributed to sample extraction and establishment of the colony; and DT and MG designed and supervised all the parts of the research and the writing of the manuscript.FundingThe study was funded by the Wellcome Trust Grant WT079408/C/06/Z issued to MG, and by an SFI FN Funded ...
Source: Frontiers in Psychiatry - April 29, 2019 Category: Psychiatry Source Type: research

Incidence, 30-day readmission rates and predictors of readmission after new onset atrial fibrillation who underwent transcatheter aortic valve replacement
ConclusionsIncidence of NOAF is associated with increased risk of readmissions and ischemic stroke. Future research should focus on interventions to prevent avoidable readmissions and associated morbidity and mortality.
Source: Heart and Lung: The Journal of Acute and Critical Care - November 3, 2019 Category: Respiratory Medicine Source Type: research

Response to letter to the editor by Kawada on “Association between nonalcoholic fatty liver disease with advanced fibrosis and stroke”
We thank Dr. Kawada for their interest [1] in our recent publication [2], in which we reported on the association between nonalcoholic fatty liver disease (NAFLD) fibrosis indices and stroke. In a large, nationally representative sample of Americans, we demonstrated a cross-sectional relationship between NAFLD-advanced fibrosis and prevalent, self-reported stroke, with variability in our findings depending on the liver fibrosis score used.
Source: Journal of the Neurological Sciences - November 6, 2019 Category: Neurology Authors: NealS. Parikh, Jose Gutierrez Tags: Letter to the Editor Source Type: research

Patients with Atrial Fibrillation Taking Nonsteroidal Anti-Inflammatory Drugs and Oral Anticoagulants in the ARISTOTLE Trial.
Conclusions: A substantial number of patients in the ARISTOTLE trial took NSAIDs. Incident NSAID use was associated with major and CRNM bleeding, but not gastrointestinal bleeding. The safety and efficacy of apixaban versus warfarin appeared not significantly to be altered by NSAID use. This study warrants more investigation of the effect of NSAIDs on the outcomes of patients treated with apixaban. Clinical Trial Registration: URL: https://clinicaltrials.gov Unique Identifier: NCT00412984. PMID: 31747786 [PubMed - as supplied by publisher]
Source: Circulation - November 20, 2019 Category: Cardiology Authors: Dalgaard F, Mulder H, Wojdyla DM, Lopes RD, Held C, Alexander JH, De Caterina R, Washam JB, Hylek EM, Garcia DA, Gersh BJ, Wallentin L, Granger CB, Al-Khatib SM Tags: Circulation Source Type: research

Efficacy and Safety of Direct Oral Anticoagulants in Patients with Atrial Fibrillation and Liver Disease: a Meta-Analysis and Systematic Review
ConclusionsOur findings suggest that DOACs significantly reduce the risk of ischemic stroke, major bleeding, and ICH, with no significant effect on the risk of gastrointestinal bleeding in AF patients with liver disease compared with warfarin.
Source: Cardiovascular Drugs and Therapy - September 2, 2020 Category: Cardiology Source Type: research

IJERPH, Vol. 17, Pages 8549: Migraine as a Risk Factor for Peripheral Artery Occlusive Disease: A Population-Based Cohort Study
In conclusion, the presence of migraine is a significant risk factor for the development of subsequent PAOD.
Source: International Journal of Environmental Research and Public Health - November 18, 2020 Category: Environmental Health Authors: Fu-Hsuan Kuo Chia-Yi Lee Ju-Pi Li Jui-Fu Chung Yu-Hsun Wang Ming-Ju Hsieh Shun-Fa Yang Tags: Article Source Type: research

Impact of Non-Alcoholic Fatty Liver Disease on Metabolic Comorbidities in Type 2 Diabetes Mellitus
Conclusion The coded prevalence of NAFLD in T2D patients is low, which is in contrast to published series. Enhancing disease awareness of NAFLD and screening recommendations in high risk populations will be beneficial for the active management of these patients. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Experimental and Clinical Endocrinology and Diabetes - February 18, 2021 Category: Endocrinology Authors: Labenz, Christian Kostev, Karel Alqahtani, Saleh A. Galle, Peter R. Schattenberg, J örn M. Tags: Article Source Type: research

Trends in Anticoagulant Use at Nursing Home Admission and Variation by Frailty and Chronic Kidney Disease Among Older Adults with Atrial Fibrillation
ConclusionsWhile the proportion of residents with AF receiving oral anticoagulants at admission increased following the approval of DOACs, over 40% remained untreated. Among those treated, use of a DOAC increased, while warfarin use declined. The impact of these recent treatment patterns on the balance between benefit and harm among residents warrant further investigation.
Source: Drugs and Aging - April 21, 2021 Category: Geriatrics Source Type: research

Association between the liver fat score (LFS) and cardiovascular diseases in the national health and nutrition examination survey 1999-2016
CONCLUSIONS: NAFLD is usually asymptomatic, but this large study of a large general population shows that LFS is associated with CHD, CHF, angina pectoris, cardiovascular and all-cause mortality. Determining the LFS is worthwhile, as it identifies people with NAFLD, who may also be at increased cardiovascular risk.Key MessagesLiver fat score (LFS), a non-invasive marker of non-alcoholic fatty liver disease (NAFLD), is associated with coronary heart disease (CHD), congestive heart failure (CHF) and angina.LFS is also associated with increased cardiovascular and all-cause mortality.Determining the LFS is worthwhile as it ide...
Source: Annals of Medicine - June 29, 2021 Category: Internal Medicine Authors: Chun-On Lee Hang-Long Li Man-Fung Tsoi Ching-Lung Cheung Bernard Man Yung Cheung Source Type: research

Proton Pump Inhibitors and the Risk of Community-Acquired Pneumonia: An Updated Meta-analysis
CONCLUSIONS AND RELEVANCE: Using PPI could increase the risk of CAP when compared to not using PPI. PPI use increased the incidence of CAP in patients with stroke. Clinicians and clinical pharmacists should weigh the benefits before medication and strictly control the indication of the prescription, so as to reduce adverse reactions.PMID:34425689 | DOI:10.1177/10600280211039240
Source: The Annals of Pharmacotherapy - August 24, 2021 Category: Drugs & Pharmacology Authors: Xuejiao Xun Qifan Yin Yuhao Fu Xueru He Zhanjun Dong Source Type: research