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Specialty: Neurology
Condition: Stroke
Cancer: Brain Cancers
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Total 371 results found since Jan 2013.
The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion.
This study indicates that FCPR16 has protective effects against cerebral ischemia-reperfusion injury through inhibiting inflammation and apoptosis via the cAMP/CREB pathway, while it has low emetogenic potential.
PMID: 29155261 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - November 16, 2017 Category: Neurology Authors: Chen J, Yu H, Zhong J, Feng H, Wang H, Cheng Y, Zou Z, Huang C, Zhou Z, Zheng W, Xu J Tags: Brain Res Bull Source Type: research
Headache and pregnancy: a systematic review
AbstractThis systematic review summarizes the existing data on headache and pregnancy with a scope on clinical headache phenotypes, treatment of headaches in pregnancy and effects of headache medications on the child during pregnancy and breastfeeding, headache related complications, and diagnostics of headache in pregnancy. Headache during pregnancy can be both primary and secondary, and in the last case can be a symptom of a life-threatening condition. The most common secondary headaches are stroke, cerebral venous thrombosis, subarachnoid hemorrhage, pituitary tumor, choriocarcinoma, eclampsia, preeclampsia, idiopathic ...
Source: The Journal of Headache and Pain - October 19, 2017 Category: Neurology Source Type: research
Nivolumab-induced posterior reversible encephalopathy syndrome
A 47-year-old woman with metastatic, poorly differentiated lung cancer with neuroendocrine features was brought to the hospital after 4 days of nausea, vomiting, disorientation, and 1 generalized tonic clonic seizure. On examination, her blood pressure was 148/95 mm Hg, heart rate 95 bpm, and temperature 36.4°C. She was encephalopathic and had cortical blindness. She had no history of seizures or visual impairment. MRI brain without contrast showed changes consistent with posterior reversible encephalopathy syndrome (PRES; figure, A). She had been on nivolumab, of which she had received 2 doses; the last dose was 24 da...
Source: Neurology Clinical Practice - October 16, 2017 Category: Neurology Authors: Hussein, H. M., Dornfeld, B., Schneider, D. J. Tags: MRI, Other cerebrovascular disease/ Stroke, All Clinical Neurology, Chemotherapy-tumor Case Source Type: research
Chapter 37 Overview of neuroradiology
Publication date: 2017 Source:Handbook of Clinical Neurology, Volume 145 Author(s): Elna-Marie Larsson, Johan Wikström Neuroradiology with computed tomography (CT) and magnetic resonance imaging (MRI) is essential for the initial evaluation of patients with a clinical suspicion of brain and spine disorders. Morphologic imaging is required to obtain a probable diagnosis to support the treatment decisions in pre- and perinatal disorders, vascular diseases, traumatic injuries, metabolic disorders, epilepsy, infection/inflammation, neurodegenerative disorders, degenerative spinal disease, and tumors of the central nervous sy...
Source: Handbook of Clinical Neurology - October 4, 2017 Category: Neurology Source Type: research
Global, regional, and national burden of neurological disorders during 1990 –2015: a systematic analysis for the Global Burden of Disease Study 2015
Publication date: Available online 17 September 2017 Source:The Lancet Neurology Author(s): GBD 2015 Neurological Disorders Collaborator GroupValery LFeiginAmanuel AlemuAbajobirKalkidan HassenAbateFoadAbd-AllahAbdishakur MAbdulleSemaw FeredeAberaGebre YitayihAbyuMuktar BeshirAhmedAmani NidhalAichourIbtihelAichourMiloud Taki EddineAichourRufus OlusolaAkinyemiSamerAlabedRajaaAl-RaddadiNelsonAlvis-GuzmanAzmeraw T.AmareHosseinAnsariPalwashaAnwariJohanÄrnlövHamidAsayeshSolomon WeldegebrealAsgedomTesfay MehariAteyLeticiaAvila-BurgosEuripideFrinelG. ArthurAvokpahoAleksandraBaracMiguelBarbozaSuzanne LBarker-ColloTillBärnighaus...
Source: The Lancet Neurology - September 19, 2017 Category: Neurology Source Type: research
Comment on “Orthostatic myoclonus after brain tumor radiation: Insights from two lesional cases”
We were intrigued by an article in press in Parkinsonism and Related Disorders, “Orthostatic myoclonus after brain tumor radiation: insights from two lesional cases” [1] by Cutsforth-Gregory et al. for several reasons. Their observation that the generator of orthostatic myoclonus (OM) likely localizes to the frontal lobes is consistent with our conclusions, based on a case of unilateral OM secondary to a contralateral frontal lobe stroke [2], as well as the high frequency of OM patients who have severe microvascular leukoencephalopathy (MVL) affecting the frontal, medial centrum semiovale [2,3].
Source: Parkinsonism and Related Disorders - September 1, 2017 Category: Neurology Authors: J.A. van Gerpen, Anhar Hassan Tags: Correspondence Source Type: research
Proinflammatory cytokines correlate with early exercise attenuating anxiety ‐like behavior after cerebral ischemia
ConclusionOur results indicated that early treadmill exercise attenuated anxiety‐like behavior by decreasing inflammation response, exercise conferred a great benefit of attenuating anxiety‐like behavior via anti‐inflammatory treatment may prove to be a novel neuroprotective strategy for stroke.
The manuscript provided novel evidence that early exercise‐associated decrease in neuroinflammation accompanied by a reduction in anxiety‐like behavior and cognitive impairment after the stroke. Based on these findings, we proposed that early exercise attenuated inflammation directly contributing to improve neuroprogress...
Source: Brain and Behavior - September 1, 2017 Category: Neurology Authors: Qi Zhang, Jingjun Zhang, Yuzhong Yan, Pengyue Zhang, Wei Zhang, Rong Xia Tags: ORIGINAL RESEARCH Source Type: research
European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis – endorsed by the European Academy of Neurology
ConclusionsMulticentre observational and experimental studies are needed to increase the level of evidence supporting recommendations on the diagnosis and management of CVT.
Source: European Journal of Neurology - August 20, 2017 Category: Neurology Authors: J. M. Ferro, M. ‐G. Bousser, P. Canhão, J. M. Coutinho, I. Crassard, F. Dentali, M. Minno, A. Maino, I. Martinelli, F. Masuhr, D. Aguiar de Sousa, J. Stam, Tags: Guidelines Source Type: research
Deletion of the P2X4 receptor is neuroprotective acutely, but induces a depressive phenotype during recovery from ischemic stroke
Conclusions P2X4R deletion protects against stroke acutely but predisposes to depression-like behavior chronically after stroke. Thus, a time-sensitive approach should be considered when targeting P2X4Rs after stroke.
Source: Brain, Behavior, and Immunity - July 24, 2017 Category: Neurology Source Type: research
Deletion of the P2X4 receptor is neuroprotective acutely, but induces a depressive phenotype during recovery from ischemic stroke.
CONCLUSIONS: P2X4R deletion protects against stroke acutely but predisposes to depression-like behavior chronically after stroke. Thus, a time-sensitive approach should be considered when targeting P2X4Rs after stroke.
PMID: 28751018 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - July 24, 2017 Category: Neurology Authors: Verma R, Cronin CG, Hudobenko J, Venna VR, McCullough LD, Liang BT Tags: Brain Behav Immun Source Type: research
Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1-Dependent M1 Microglial Polarization Basic Sciences
Conclusions—Our findings indicate that H19 promotes neuroinflammation by driving HDAC1-dependent M1 microglial polarization, suggesting a novel H19-based diagnosis and therapy for ischemic stroke.
Source: Stroke - July 24, 2017 Category: Neurology Authors: Jue Wang, Haiping Zhao, Zhibin Fan, Guangwen Li, Qingfeng Ma, Zhen Tao, Rongliang Wang, Juan Feng, Yumin Luo Tags: Animal Models of Human Disease, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Hospital safety among neurologic patients: A population-based cohort study of adverse events
Conclusions:
This study demonstrates that neurologic patients have a high proportion of AEs in hospital. The findings provide information on the quality and safety of care for people with neurologic conditions in hospital, which can help inform future quality improvement initiatives.
Source: Neurology - July 17, 2017 Category: Neurology Authors: Sauro, K. M., Quan, H., Sikdar, K. C., Faris, P., Jette, N. Tags: All Health Services Research, Medical care, All Clinical Neurology, Patient safety ARTICLE Source Type: research
Application of Solution-Focused Brief Therapy (SFBT) in individuals after stroke.
CONCLUSIONS: The authors suggest SFBT as a simple, beneficial and inexpensive method to manage patients after stroke.
PMID: 28696135 [PubMed - as supplied by publisher]
Source: Brain Injury - July 13, 2017 Category: Neurology Tags: Brain Inj Source Type: research
Protective Effects of Spatholobi Caulis Extract on Neuronal Damage and Focal Ischemic Stroke/Reperfusion Injury
AbstractNeuronal apoptotic cell death plays an important role in many neurological disorders, including Alzheimer ’s disease, Parkinson’s disease, and ischemic stroke. Spatholobi Caulis (SC) has been widely used in traditional herbal medicine for the treatment of cancer, inflammation, viral infection, and anemia. However, the protective effects of SC extract (SCE) against apoptotic cell death in the brain h ave not been reported. We investigated the protective effects of SCE against neuronal injury etoposide-induced neurotoxicity and in rats subjected to focal transient ischemic stroke middle cerebral artery occlusion ...
Source: Molecular Neurobiology - July 13, 2017 Category: Neurology Source Type: research
MicroRNA-15a/16-1 Antagomir Ameliorates Ischemic Brain Injury in Experimental Stroke Basic Sciences
Conclusions—Our data indicate that pharmacological inhibition of the miR-15a/16-1 cluster reduces ischemic brain injury via both upregulation of antiapoptotic proteins and suppression of proinflammatory molecules. These results suggest that the miR-15a/16-1 cluster is a novel therapeutic target for ischemic stroke.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Xinxin Yang, Xuelian Tang, Ping Sun, Yejie Shi, Kai Liu, Sulaiman H. Hassan, R. Anne Stetler, Jun Chen, Ke-Jie Yin Tags: Basic Science Research, Ischemic Stroke Original Contributions Source Type: research
