MicroRNA-15a/16-1 Antagomir Ameliorates Ischemic Brain Injury in Experimental Stroke [Basic Sciences]

Conclusions—Our data indicate that pharmacological inhibition of the miR-15a/16-1 cluster reduces ischemic brain injury via both upregulation of antiapoptotic proteins and suppression of proinflammatory molecules. These results suggest that the miR-15a/16-1 cluster is a novel therapeutic target for ischemic stroke.

Source: Stroke - June 26, 2017 Category: Neurology Authors: Xinxin Yang, Xuelian Tang, Ping Sun, Yejie Shi, Kai Liu, Sulaiman H. Hassan, R. Anne Stetler, Jun Chen, Ke-Jie Yin Tags: Basic Science Research, Ischemic Stroke Original Contributions Source Type: research