Deletion of the P2X4 receptor is neuroprotective acutely, but induces a depressive phenotype during recovery from ischemic stroke.

CONCLUSIONS: P2X4R deletion protects against stroke acutely but predisposes to depression-like behavior chronically after stroke. Thus, a time-sensitive approach should be considered when targeting P2X4Rs after stroke. PMID: 28751018 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28751018?dopt=Abstract

Source: Brain, Behavior, and Immunity - July 24, 2017 Category: Neurology Authors: Verma R, Cronin CG, Hudobenko J, Venna VR, McCullough LD, Liang BT Tags: Brain Behav Immun Source Type: research