Filtered By:
Cancer: Skin Cancer

This page shows you your search results in order of relevance. This is page number 15.

Order by Relevance | Date

Total 2013 results found since Jan 2013.

Protein phosphatase 2A (PP2A) inhibitor CIP2A indicates resistance to radiotherapy in rectal cancer
In conclusion, these results suggest that by contributing to radiosensitivity of cancer cells, low CIP2A protein expression level associates with a favorable response to long‐course (C)RT in rectal cancer patients. Low CIP2A protein expression level associates with a favorable response to long‐course chemoradiotherapy in rectal cancer patients. Suppression of CIP2A transcription by siRNA sensitizes colorectal cancer cells to irradiation and decreases their survival in vitro.
Source: Cancer Medicine - February 14, 2018 Category: Cancer & Oncology Authors: Eva ‐Maria Birkman, Adam Elzagheid, Terhi Jokilehto, Tuulia Avoranta, Eija Korkeila, Jarmo Kulmala, Kari Syrjänen, Jukka Westermarck, Jari Sundström Tags: Original Research Source Type: research

Cyclin-Dependent Kinase Inhibitor 3 Promoted Cell Proliferation by Driving Cell Cycle from G1 to S Phase in Esophageal Squamous Cell Carcinoma
Conclusions: Our study suggested that CDKN3 acted as an oncogene in human ESCC and may accelerate the G1/S transition by affecting CyclinD-CDK4 complex via regulating pAKT-p53-p21 axis and p27 independent of AKT.
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Juan Liu, Li Min, Shengtao Zhu, Qingdong Guo, Hengcun Li, Zheng Zhang, Yu Zhao, Changqin Xu, Shutian Zhang Tags: Research Paper Source Type: research

Suppression of the long non-coding RNA MALAT-1 impairs the growth and migration of human tongue squamous cell carcinoma SCC4 cells.
Conclusions: Elevated expression of MALAT-1 in OSCC may play a role in tumorigenesis and/or metastasis. Further studies are necessary to identify the mechanism by which MALAT-1 influences SCC4 growth and migration and validate its increased expression in OSCC patients. PMID: 31360193 [PubMed]
Source: Archives of Medical Science - August 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

LncRNA ZEB1-AS1 down-regulation suppresses the proliferation and invasion by inhibiting ZEB1 expression in oesophageal squamous cell carcinoma.
In conclusion, ZEB1-AS1 overexpression is tightly involved in the development and progression of ESCC, and it exerts the antitumour efficacy by regulating ZEB1 level in ESCC. PMID: 31638344 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - October 21, 2019 Category: Molecular Biology Authors: Zhao Y, Wang N, Zhang X, Liu H, Yang S Tags: J Cell Mol Med Source Type: research

Long non-coding RNA MIAT promotes the growth of melanoma via targeting miR-150
In conclusion, we reported that MIAT promotes the proliferation, invasion and EMT of melanoma cells via targeting miR-150, which suggested that MIAT might be a therapeutic target for the treatment of melanom a.
Source: Human Cell - April 15, 2020 Category: Cytology Source Type: research

MiR-26a inhibits proliferation and apoptosis of uveal melanoma cells via regulating p53/MDM2 pathway.
CONCLUSIONS: Highly expressed miR-26a can inhibit the proliferation and promote apoptosis of SP6.5 cells, whose potential mechanism may be related to the regulation on the p53/MDM2 pathway. PMID: 33277871 [PubMed - as supplied by publisher]
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes
Conclusion: RIG-I and MDA5 may play a role in the antiviral responses of podocytes.
Source: In Vivo - January 5, 2021 Category: Research Authors: NAKATA, M., SHIMADA, M., NARITA-KINJO, I., NAGAWA, D., KITAYAMA, K., HAMADATE, M., MIURA, N., NOZAKA, M., KAWAMURA, Y., FUJITA, T., MURAKAMI, R., IMAIZUMI, T., NAKAMURA, N., TOMITA, H. Tags: Experimental Studies Source Type: research

Cancers, Vol. 13, Pages 166: Molecular Targeting of HuR Oncoprotein Suppresses MITF and Induces Apoptosis in Melanoma Cells
Conclusion: HuR-NP exhibited antitumor activity in melanoma cells independent of their oncogenic B-RAF mutational status. Additionally, combinatorial therapy incorporating MEK inhibitor holds promise in overriding MITF-mediated drug resistance in melanoma.
Source: Cancers - January 6, 2021 Category: Cancer & Oncology Authors: Rebaz Ahmed Ranganayaki Muralidharan Akhil Srivastava Sarah E. Johnston Yan D. Zhao Suhendan Ekmekcioglu Anupama Munshi Rajagopal Ramesh Tags: Article Source Type: research

Systemic delivery of small interfering RNA by use of targeted polycation liposomes for cancer therapy.
Abstract Novel polycation liposomes decorated with cyclic(Cys-Arg-Gly-Asp-D-Phe) peptide (cyclicRGD)-polyethylene glycol (PEG) (RGD-PEG-polycation liposomes (PCL)) were previously developed for cancer therapy based on RNA interference. Here, we demonstrate the in vivo delivery of small interfering RNA (siRNA) to tumors by use of RGD-PEG-PCL in B16F10 melanoma-bearing mice. Pharmacokinetic data obtained by positron emission tomography showed that cholesterol-conjugated siRNA formulated in RGD-PEG-PCL markedly accumulated in the tumors. Delivered by RGD-PEG-PCL, a therapeutic cocktail of siRNAs composed of cholester...
Source: Biological and Pharmaceutical Bulletin - February 10, 2013 Category: Drugs & Pharmacology Authors: Kenjo E, Asai T, Yonenaga N, Ando H, Ishii T, Hatanaka K, Shimizu K, Urita Y, Dewa T, Nango M, Tsukada H, Oku N Tags: Biol Pharm Bull Source Type: research

Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer.
CONCLUSION: This study identified a wide array of druggable genes for both lung and head and neck cancer. In particular, multiple genes involved in the G2-M checkpoint were shown to be essential for tumor cell survival, indicating their potential as anticancer targets. Clin Cancer Res; 19(8); 1994-2003. ©2013 AACR. PMID: 23444224 [PubMed - in process]
Source: Clinical Lung Cancer - April 15, 2013 Category: Cancer & Oncology Authors: Martens-de Kemp SR, Nagel R, Stigter-van Walsum M, van der Meulen IH, van Beusechem VW, Braakhuis BJ, Brakenhoff RH Tags: Clin Cancer Res Source Type: research

RRM2 Regulates Bcl-2 in Head and Neck and Lung Cancers: A Potential Target for Cancer Therapy.
CONCLUSIONS: Our novel findings add to the knowledge of RRM2 in regulating expression of the anti-apoptotic protein Bcl-2 and reveal a critical link between RRM2 and Bcl-2 in apoptosis signaling. PMID: 23719266 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - May 29, 2013 Category: Cancer & Oncology Authors: Rahman MA, Amin AR, Wang D, Koenig L, Nannapaneni S, Chen Z, Wang Z, Sica GL, Deng X, Chen ZG, Shin DM Tags: Clin Cancer Res Source Type: research

High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients
Conclusions: Our results suggest that Wee1 may be involved in the progression of vulvar carcinomas. Based on our in vitro results, Wee1 is unlikely to function as a target for mono-treatment of these patients.
Source: BMC Cancer - June 14, 2013 Category: Cancer & Oncology Authors: Gry MagnussenEllen HellesyltJahn NeslandClaes TropeVivi FlørenesRuth Holm Source Type: research

Sticky siRNAs targeting survivin and cyclin B1 exert an antitumoral effect on melanoma subcutaneous xenografts and lung metastases
Conclusion: PEI-mediated delivery of sticky siRNAs targeting genes involved in tumor progression such as survivin and cyclin B1, either alone or in combination with chemotherapeutic drugs, represents a promising strategy for melanoma treatment.
Source: BMC Cancer - July 9, 2013 Category: Cancer & Oncology Authors: Valerie KedingerAline MeulleOmar ZounibMarie-Elise BonnetJean-Baptiste GossartElodie BenoitMelanie MessmerPattabhiraman ShankaranarayananJean-Paul BehrPatrick ErbacherAnne-Laure Bolcato-Bellemin Source Type: research

Possible roles of barrier-to-autointegration factor 1 in regulation of keratinocyte differentiation and proliferation
Conclusion: BANF1 is translocated onto the nuclear envelope in the psoriatic epidermal keratinocytes, suggesting that BANF1 is associated with upregulated proliferation of keratinocytes in psoriatic lesions. Activation of BANF1 possibly suppresses S100A9 expression and inactivates c-Jun, resulting in suppression of cutaneous inflammation.
Source: Journal of Dermatological Science - May 10, 2013 Category: Dermatology Authors: Hiroyuki Takama, Kazumitsu Sugiura, Yasushi Ogawa, Yoshinao Muro, Masashi Akiyama Tags: Regular Articles Source Type: research

Regulation of cell proliferation and migration in gallbladder cancer by zinc finger X-chromosomal protein.
Abstract Gallbladder carcinoma (GBC) is one of the mostly aggressive and fatal malignancies. However, little is known about the oncogenic genes that contributed to the development of GBC. Zinc finger X-chromosomal protein (ZFX) was a novel member of the Krueppel C2H2-type zinc-finger protein family and its down-regulation led to impaired cell growth in human laryngeal squamous cell carcinoma. Here, we aim to investigate the function of ZFX in GBC cell proliferation and migration. Loss of function analysis was performed on GBC cell line (GBC-SD) using lentivirus-mediated siRNA against ZFX. The proliferation, in vit...
Source: Gene - July 13, 2013 Category: Genetics & Stem Cells Authors: Tan Z, Zhang S, Li M, Wu X, Weng H, Ding Q, Cao Y, Bao R, Shu Y, Mu J, Ding Q, Wu W, Yang J, Zhang L, Liu Y Tags: Gene Source Type: research