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Cancer: Liver Cancer

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Total 1432 results found since Jan 2013.

NOR1 promotes hepatocellular carcinoma cell proliferation and migration through modulating the Notch signaling pathway.
In conclusion, these results indicate that NOR1 may be involved in the progression of HCC and thus may be a potential target for the treatment of liver cancer. PMID: 28232113 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - February 19, 2017 Category: Cytology Authors: You K, Sun P, Yue Z, Li J, Xiong W, Wang J Tags: Exp Cell Res Source Type: research

Hepatitis B virus X protein increases microRNA ‑21 expression and accelerates the development of hepatoma via the phosphatase and tensin homolog/phosphoinositide 3‑kinase/protein kinase B signaling pathway.
Hepatitis B virus X protein increases microRNA‑21 expression and accelerates the development of hepatoma via the phosphatase and tensin homolog/phosphoinositide 3‑kinase/protein kinase B signaling pathway. Mol Med Rep. 2017 Mar 23;: Authors: Hou Z, Quan J Abstract Hepatitis B virus (HBV) X protein (HBx) is a key regulatory protein that is involved in HBV infection, replication and carcinogenesis of hepatocellular carcinoma (HCC). The aim of the present study was to investigate the role of HBx in the progression and metastasis of liver cancer cells and to determine the underlying molecular mechanism...
Source: Molecular Medicine Reports - March 27, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

USP39 regulates the growth of SMMC-7721 cells via FoxM1.
Authors: Yuan X, Sun X, Shi X, Jiang C, Yu D, Zhang W, Ding Y Abstract The present study investigated ubiquitin specific peptidase 39 (USP39) gene knockdown on SMMC-7721 cells in vitro and in vivo, and the role of USP39 in regulating the growth of hepatocellular carcinoma (HCC). Two small interfering RNAs (siRNA) were constructed, which targeted the USP39 gene and control sequences were synthesized and inserted into a pGCSIL-GFP lentiviral vector. The full length of USP39 cDNA was amplified by polymerase chain reaction (PCR) and cloned into pEGFP-N2, and the recombinant plasmids were transfected into cells. Knockdo...
Source: Experimental and Therapeutic Medicine - April 18, 2017 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Vascular endothelial growth factor: Evidence for autocrine signaling in hepatocellular carcinoma cell lines affecting invasion
CONCLUSION: Our data indicates that autocrine signaling of VEGF through its receptors exists in HCC cell lines, which has important implications for tumor invasion, metastasis, and for designing interventional strategies.
Source: Indian Journal of Cancer - April 21, 2017 Category: Cancer & Oncology Authors: BK Sharma R Srinivasan YK Chawla A Chakraborti Source Type: research

Downregulation of ANP32B exerts anti-apoptotic effects in hepatocellular carcinoma
In this study, we elucidated the role of ANP32B in HCC cell lines and tissues. ANP32B expression in HCC cell lines was modulated using siRNA and ANP32B expression plasmids and lentiviruses. The levels of apoptosis-related proteins were analyzed by real-time RT-PCR and Western blotting. The expressi on of ANP32B in tissues from patients with HCC was investigated using real-time RT-PCR and immunohistochemistry. ANP32B knockdown by siRNA altered the expression of apoptosis-related proteins in HCC cell lines and reduced the expression of cleaved forms of caspase 3 and caspase 9, but not that of ca spase 8, in HCC cells culture...
Source: PLoS One - May 9, 2017 Category: Biomedical Science Authors: Yoshinori Ohno Source Type: research

GSE68778 Targeting of WEE1 suppresses tumorigenecity and cancer stem cell-like phenotype in hepatocellular carcinoma
Contributors : Yun-Han Lee ; Deakwan Seo ; Snorri S ThorgeirssonSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe current standard-of-care for advanced liver cancer is limited. Therefore, there is an urgent need for development of novel molecular targeted therapy. Increase of WEE1 kinase activity through an epigenetic regulation plays an important role in the development of hepatocellular carcinoma (HCC). Here we demonstrated that WEE1 siRNA silencing caused inhibition of HCC cell growth through blockade of cell cycle progression and induction of apoptosis. The anti-proliferative effects were driven by ...
Source: GEO: Gene Expression Omnibus - May 31, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Increased 18F-FDGuptake on PET in hepatocellular carcinoma is associated with level ofPDL1 expression that regulated by beta-catenin
Conclusion: The above results demonstrate that 18F-FDG PET/CT is closely related to the expression of PDL1 in HCC, and it is an important criterion that not only predicts the anti-cancer response of anti-PDL1 immunotherapy through that 18F-FDG PET/CT but also reflects the prognosis Research Support: This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. NRF-2011-0030086) and and was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2016R1E1A1A01943303) and h was supported by the Basic Science Rese...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Jeon, J., Lee, M., Kim, Y. S., Yun, M. Tags: Radiotherapy and Monitoring Therapy Source Type: research

Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway.
Authors: Guo H, Lin W, Zhang X, Zhang X, Hu Z, Li L, Duan Z, Zhang J, Ren F Abstract Kaempferol is a flavonoid compound that has gained widespread attention due to its antitumor functions. However, the underlying mechanisms are still not clear. The present study investigated the effect of kaempferol on hepatocellular carcinoma and its underlying mechanisms. Kaempferol induced autophagy in a concentration- and time-dependent manner in HepG2 or Huh7 cells, which was evidenced by the significant increase of autophagy-related genes. Inhibition of autophagy pathway, through 3-methyladenine or Atg7 siRNA, strongly dimini...
Source: Oncotarget - July 28, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

GSK-3 β suppresses HCC cell dissociation in vitro by upregulating epithelial junction proteins and inhibiting Wnt/ β -catenin signaling pathway
In conclusion, GSK-3β might play a vital role in suppressing HCC dissociation by preventing the disassembly of cancer cell epithelial junctional complex via the GSK-3β/β-catenin pathway.
Source: Journal of Cancer - September 12, 2017 Category: Cancer & Oncology Authors: Jing-Hua Zhang, Li-Yan Jiao, Tie-Jun Li, York Yuanyuan Zhu, Jian-Wei Zhou, Jian Tian Tags: Research Paper Source Type: research

Long non ‐coding RNA cox‐2 prevents immune evasion and metastasis of hepatocellular carcinoma by altering M1/M2 macrophage polarization
Conclusion: These findings indicate that lncRNA cox‐2 inhibits HCC immune evasion and tumor growth by inhibiting the polarization of M2 macrophages. This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - November 13, 2017 Category: Biochemistry Authors: Yibiao Ye, Yunxiuxiu Xu, Yu Lai, Wenguang He, Yanshan Li, Ruomei Wang, Xinxi Luo, Xinxi Luo, Rufu Chen, Tao Chen Tags: Article Source Type: research

Role of Glypican-3 in the growth, migration and invasion of primary hepatocytes isolated from patients with hepatocellular carcinoma
ConclusionOur data reveal new aspects of the role of GPC3 in early hepatocyte transformation. In addition we conclude that GPC3 may serve as a new HCC immune-therapeutic target.
Source: Cellular Oncology - December 4, 2017 Category: Cancer & Oncology Source Type: research

Cisplatin induces apoptosis of hepatocellular carcinoma LM3 cells via down-regulation of XIAP.
CONCLUSIONS: Downregulation of XIAP enhanced the proapoptotic effect of cisplatin on LM3 cells, suggesting that XIAP might be used as a potential target in the treatment of liver cancer. PMID: 29424923 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Cyclin Y Modulates the Proliferation, Invasion, and Metastasis of Hepatocellular Carcinoma Cells.
CONCLUSIONS In tissue samples of human HCC, and human HCC cell lines, increased expression of CCNY was significantly associated with cell proliferation and migration. Further studies are recommended to evaluate the role of CCNY as a potential diagnostic biomarker or target for treatment in human HCC. PMID: 29557391 [PubMed - in process]
Source: Medical Science Monitor - March 22, 2018 Category: Research Tags: Med Sci Monit Source Type: research

POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim.
Abstract The ubiquitin-proteasome system is implicated in cell apoptosis that is frequently dysregulated in human cancers. POH1/rpn11/PSMD14, as a part of the 19S proteasomal subunit, contributes to the progression of malignancy, but its role in apoptosis remains unclear. Here, we showed that POH1 expression was increased and associated with poor outcomes in three independent cohorts of patients with hepatocellular carcinoma (HCC), esophageal cancer (EC), and colorectal cancer (CRC). The knockdown of POH1 significantly inhibited tumor cell proliferation and induced apoptosis mediated by the mitochondrial pathway i...
Source: Neoplasia - March 21, 2018 Category: Cancer & Oncology Authors: Wang CH, Lu SX, Liu LL, Li Y, Yang X, He YF, Chen SL, Cai SH, Wang H, Yun JP Tags: Neoplasia Source Type: research

RNA-binding protein AUF1 suppresses miR-122 biogenesis by down-regulating Dicer1 in hepatocellular carcinoma.
In conclusion, AUF1 down-regulates the expression miR-122 by interacting with the 3'UTR and coding region of DICER1 mRNA and suppressing Dicer1 expression. The AUF1/Dicer1/miR-122 pathway might play a critical role in the development of HCC. PMID: 29599909 [PubMed]
Source: Oncotarget - April 1, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research