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In vitro inhibitory properties of sesquiterpenes from Chloranthus serratus on cell motility via down-regulation of LIMK1 activation in human breast cancer
Conclusion collectively, it was concluded that SERA exhibited significant inhibitory effects on breast cancer cells migration, and these effects of this sesquiterpene are due to its properties reducing the activation of LIM kinase 1. Graphical abstract
Source: Phytomedicine - June 14, 2018 Category: Drugs & Pharmacology Source Type: research

Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway.
CONCLUSIONS Baicalin, a flavonoid used in Chinese herbal medicine, inhibited the proliferation and migration of human NSCLC cells, A549 and H1299, by activating the SIRT1/AMPK signaling pathway. PMID: 29632297 [PubMed - in process]
Source: Medical Science Monitor - April 13, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Molecules, Vol. 22, Pages 892: The Cytotoxicity of the Ajoene Analogue BisPMB in WHCO1 Oesophageal Cancer Cells Is Mediated by CHOP/GADD153
Garlic is a food and medicinal plant that has been used in folk medicine since ancient times for its beneficial health effects, which include protection against cancer. Crushed garlic cloves contain an array of small sulfur-rich compounds such as ajoene. Ajoene is able to interfere with biological processes and is cytotoxic to cancer cells in the low micromolar range. BisPMB is a synthetic ajoene analogue that has been shown in our laboratory to have superior cytotoxicity to ajoene. In the current study we have performed a DNA microarray analysis of bisPMB-treated WHCO1 oesophageal cancer cells to identify pathways and pro...
Source: Molecules - May 28, 2017 Category: Chemistry Authors: Vuyolwethu Siyo Georgia Sch äfer Roger Hunter Andriy Grafov Iryna Grafova Martin Nieger Arieh A. Katz M. Iqbal Parker Catherine H. Kaschula Tags: Article Source Type: research

Taraxacum mongolicum extract induced endoplasmic reticulum stress associated-apoptosis in triple-negative breast cancer cells
Conclusion ER stress related cell apoptosis accounted for the anti-cancer effect of dandelion extract, and these findings support dandelion extract might be a potential therapeutic approach to treat TNBC. Graphical abstract
Source: Journal of Ethnopharmacology - April 29, 2017 Category: Drugs & Pharmacology Source Type: research

Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
In conclusion, our data indicated that shikonin treatment induced necroptosis and autophagy in NSCLC cells. In addition, inhibition of shikonin-induced autophagy enhanced necroptosis, suggesting that shikonin could be a novel therapeutic strategy against NSCLC.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Hwang, K. E., Jeong, E. T., Kim, H. R. Tags: 11.1 Lung Cancer Source Type: research

SH003 selectively induces p73 ‑dependent apoptosis in triple‑negative breast cancer cells.
SH003 selectively induces p73‑dependent apoptosis in triple‑negative breast cancer cells. Mol Med Rep. 2016 Sep 6; Authors: Choi EK, Kim SM, Hong SW, Moon JH, Shin JS, Kim JH, Hwang IY, Jung SA, Lee DH, Lee EY, Lee S, Kim H, Kim D, Kim YS, Choi YK, Kim HI, Choi HS, Cho SG, Kim JE, Kim KP, Hong YS, Lee WK, Lee JS, Kim TW, Ko SG, Jin DH Abstract Triple-negative breast cancer (TNBC) is a breast cancer subtype that has an aggressive phenotype, is highly metastatic, has limited treatment options and is associated with a poor prognosis. In addition, metastatic TNBC has no preferred standard chemotherapy ...
Source: Molecular Medicine Reports - September 10, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Modified Panax ginseng Extract Inhibits uPAR-Mediated αFormula: see textβ1-Integrin Signaling by Modulating Caveolin-1 to Induce Early Apoptosis in Lung Cancer Cells.
Abstract Urokinase receptor (uPAR) is enhanced in many human cancer cells and is frequently an indicator of poor prognosis. Activation of [Formula: see text]1-integrin requires caveolin-1 and is regulated by uPAR. However, the underlying molecular mechanism responsible for the interaction between uPAR and [Formula: see text]1-integrin remains obscure. We found that modified regular Panax ginseng extract (MRGX) had a negative modulating effect on the uPAR/[Formula: see text]1-integrin interaction, disrupted the uPAR/integrin interaction by modulating caveoline-1, and caused early apoptosis in cancer cells. Addition...
Source: The American Journal of Chinese Medicine - July 18, 2016 Category: Complementary Medicine Authors: Hwang IH, Kwon YK, Cho CK, Lee YW, Sung JS, Joo JC, Lee KB, Yoo HS, Jang IS Tags: Am J Chin Med Source Type: research

Astragalus polysaccharide induces the apoptosis of human hepatocellular carcinoma cells by decreasing the expression of Notch1.
Abstract Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer death worldwide. Astragalus polysaccharide (APS), the primary active component extracted from a traditional Chinese medicinal herb Astragalus membranaceus, has been proved to exert a marked inhibitory effect on a number of types of human solid tumors. In the present study, we aimed to examine the effects of APS on the survival of the HCC cell line H22 and to elucidate the underlying regulatory mechanisms responsible for these effects. Our results revealed that the mRNA and protein expression of Notch1 was significantly upregulate...
Source: International Journal of Molecular Medicine - June 8, 2016 Category: Molecular Biology Authors: Huang WH, Liao WR, Sun RX Tags: Int J Mol Med Source Type: research

Ophiopogonin B induces apoptosis, mitotic catastrophe and autophagy in A549 cells.
Abstract Ophiopogonin B (OP-B), a saponin compound isolated from Radix Ophiopogon japonicus, was verified to inhibit cell proliferation in numerous non-small cell lung cancer (NSCLC) cells in our previous study. However, the precise mechanisms of action have remained unclear. In the present study, we mainly investigated the effects of OP-B on adenocarcinoma A549 cells to further elaborate the underlying mechanisms of OP-B in different NSCLC cell lines. Detection by high content screening (HCS) and TUNEL assay verified that OP-B induced apoptosis in this cell line, while detection of Caspase-3, Bcl-2 and Bax showed...
Source: International Journal of Oncology - May 9, 2016 Category: Cancer & Oncology Authors: Chen M, Guo Y, Zhao R, Wang X, Jiang M, Fu H, Zhang X Tags: Int J Oncol Source Type: research

Clinacanthus nutans Protects Cortical Neurons Against Hypoxia-Induced Toxicity by Downregulating HDAC1/6
This study further opens a new avenue for the use of herbal medicines to regulate epigenetic control of brain injury.
Source: NeuroMolecular Medicine - May 9, 2016 Category: Neurology Source Type: research

Zyflamend, a polyherbal mixture, inhibits lipogenesis and mTORC1 signalling via activation of AMPK
The objective in this study was to determine if the antiproliferative effects are mediated, in part, through the activation of AMPK signalling and inhibition of its downstream targets, lipogenesis and mTORC1 complex. By increasing the phosphorylation of AMPK in CWR22Rv1 and PC3 prostate cancer cell lines, Zyflamend decreased de novo lipid biosynthesis by decreasing the activity of acetyl-CoA carboxylase and the expressions of fatty acid synthase and SREBP-1c, with a concomitant up regulation of fatty acid oxidation. In addition, via AMPK, Zyflamend inhibited the activity of mTORC1 complex by directly phosphorylating raptor...
Source: Journal of Functional Foods - July 25, 2015 Category: Nutrition Source Type: research

Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.
In conclusion, Rg3 induces tumor cell apoptosis correlated with its inhibitory effect on NF-κB signaling pathway-mediated FUT4 expression. Results suggest Rg3 might be a novel therapy agent for melanoma treatment. PMID: 26094873 [PubMed - as supplied by publisher]
Source: International Journal of Oncology - June 18, 2015 Category: Cancer & Oncology Authors: Shan X, Tian LL, Zhang YM, Wang XQ, Yan Q, Liu JW Tags: Int J Oncol Source Type: research

Berberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through miR-93/PTEN/Akt Signaling Pathway
Conclusion: The results suggested that berberine modulated the sensitivity of cisplatin through miR-93/PTEN/AKT signaling pathway in the ovarian cancer cells.Cell Physiol Biochem 2015;36:956-965
Source: Cellular Physiology and Biochemistry - June 16, 2015 Category: Cytology Source Type: research

NBM-T-BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway
Conclusion: Taken together, this study provides that BMX might modulate cisplatin resistance through AMPK-ERK and AMPK-Akt pathways. These results also support the role of BMX as a potential drug candidate for use in combination with cisplatin in the treatment of human lung cancer.Cell Physiol Biochem 2015;36:893-906
Source: Cellular Physiology and Biochemistry - June 9, 2015 Category: Cytology Source Type: research

Tanshinones suppress AURKA through up-regulation of miR-32 expression in non-small cell lung cancer.
Authors: Ma ZL, Zhang BJ, Wang DT, Li X, Wei JL, Zhao BT, Jin Y, Li YL, Jin YX Abstract Tanshinone is the liposoluble constituent of Salia miltiorrhiza, a root used in traditional herbal medicine which is known to possess certain health benefits. Although it is known that tanshinones, including tanshinone I (T1), tanshinone IIA (T2A), and cryptotanshinone (CT), can inhibit the growth of lung cancer cells in vitro, the mechanism under which they act is still unclear. AURKA, an oncogene, encodes a serine-threonine kinase which regulates mitotic processes in mammalian cells. Here, we reported that tanshinones mediate ...
Source: Oncotarget - June 5, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

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