Microsatellite profiling of hosts from parasite-extracted DNA illustrated with raccoons (Procyon lotor) and their Baylisascaris procyonis roundworms
Important information on movement pathways and introduction routes of invasive parasites can be obtained by comparing the genetic makeup of an invader with its spatial genetic structure in other distribution a... (Source: Parasites and Vectors)
Source: Parasites and Vectors - February 25, 2023 Category: Microbiology Authors: Alain C. Frantz, St éphanie Lippert and Mike Heddergott Tags: Methodology Source Type: research
Phenotypic Profiling of Macrocyclic Lactones on Parasitic < em > Schistosoma < /em > Flatworms
Antimicrob Agents Chemother. 2023 Jan 25:e0123022. doi: 10.1128/aac.01230-22. Online ahead of print.ABSTRACTMacrocyclic lactones are front-line therapies for parasitic roundworm infections; however, there are no comprehensive studies on the activity of this drug class against parasitic flatworms. Ivermectin is well known to be inactive against flatworms. However, the structure-activity relationship of macrocyclic lactones may vary across phyla, and it is entirely possible other members of this drug class do in fact show antiparasitic activity on flatworms. For example, there are several reports hinting at the anti-schistos...
Source: Antimicrobial Agents and Chemotherapy - January 25, 2023 Category: Microbiology Authors: Kaetlyn T Ryan Nicolas J Wheeler Isaac K Kamara Hailey Johnson Judith E Humphries Mostafa Zamanian John D Chan Source Type: research
Phenotypic Profiling of Macrocyclic Lactones on Parasitic < em > Schistosoma < /em > Flatworms
Antimicrob Agents Chemother. 2023 Jan 25:e0123022. doi: 10.1128/aac.01230-22. Online ahead of print.ABSTRACTMacrocyclic lactones are front-line therapies for parasitic roundworm infections; however, there are no comprehensive studies on the activity of this drug class against parasitic flatworms. Ivermectin is well known to be inactive against flatworms. However, the structure-activity relationship of macrocyclic lactones may vary across phyla, and it is entirely possible other members of this drug class do in fact show antiparasitic activity on flatworms. For example, there are several reports hinting at the anti-schistos...
Source: Antimicrobial Agents and Chemotherapy - January 25, 2023 Category: Microbiology Authors: Kaetlyn T Ryan Nicolas J Wheeler Isaac K Kamara Hailey Johnson Judith E Humphries Mostafa Zamanian John D Chan Source Type: research
< i > Trichuris < /i > WAP and CAP proteins: Potential whipworm vaccine candidates?
by Eleanor Wainwright, Rebecca K. ShearsTrichuris trichiura andT.suis are gastrointestinal dwelling roundworms that infect humans and pigs, respectively. Heavy infections cause gastrointestinal symptoms and impaired growth and development. Vaccination has the potential to reduce the disease burden of whipworm infection; however, there are currently no commercially available vaccines against these parasites and very few against other gastrointestinal-dwelling nematodes of medical and agricultural importance. The naturally occurring mouse whipworm,T.muris, has been used for decades to model human trichuriasis, and the immuno...
Source: PLoS Neglected Tropical Diseases - December 22, 2022 Category: Tropical Medicine Authors: Eleanor Wainwright Source Type: research
Trickle infection with Heligmosomoides polygyrus results in decreased worm burdens but increased intestinal inflammation and scarring
DiscussionTo our knowledge, we are the first to identify the involvement of this protein family of matrix metalloproteinases (MMPs) in host responses to helminth infections. Our results highlight the delicate balance between parasite clearance and host tissue damage, which both contribute to host pathology. When continually exposed to parasitic worms, improved clearance comes at a cost. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - December 8, 2022 Category: Allergy & Immunology Source Type: research
GSE207152 Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging
Contributors : Tanima SenGupta ; Yohan Lefol ; Lisa Lirussi ; Veronica Suaste ; Torben Luders ; Swapnil Gupta ; Yahyah Aman ; Kulbhushan Sharma ; Evandro F Fang ; Hilde NilsenSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansThere is accumulating evidence that interfering with the basic aging mechanisms can enhance healthy longevity. Many cellular processes contribute to aging and are referred to as “hallmarks of aging”; by presumption, interventional/therapeutic strategies targeting on multiple ageing hallmarks could be more effective to delay ageing than targeti...
Source: GEO: Gene Expression Omnibus - November 30, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Caenorhabditis elegans Source Type: research
Modulation of the porcine intestinal microbiota in the course of Ascaris suum infection
The porcine roundworm Ascaris suum impairs feed conversion and weight gain, but its effects on intestinal microbiota remain largely unexplored. (Source: Parasites and Vectors)
Source: Parasites and Vectors - November 17, 2022 Category: Microbiology Authors: Andrea Springer, Liane Wagner, Sarina Koehler, Stefanie Klinger, Gerhard Breves, Dagmar A. Br üggemann and Christina Strube Tags: Research Source Type: research
The microbial community associated with Parascaris spp. infecting juvenile horses
Parasitic nematodes, including large roundworms colloquially known as ascarids, affect the health and well-being of livestock animals worldwide. The equine ascarids, Parascaris spp., are important parasites of ju... (Source: Parasites and Vectors)
Source: Parasites and Vectors - November 4, 2022 Category: Microbiology Authors: Jennifer L. Cain, Jamie K. Norris, Nichol E. Ripley, Parul Suri, Constance A. Finnerty, Holli S. Gravatte and Martin K. Nielsen Tags: Research Source Type: research
Eosinophils in filarial infections: Inducers of protection or pathology?
Filariae are parasitic roundworms, which can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Lymphatic filariasis, also known as elephantiasis, and onchocerciasis, commonly referred to as river blindness, can lead to stigmatizing pathologies and present a socio-economic burden for affected people and their endemic countries. Filariae typically induce a type 2 immune response, which is characterized by cytokines, i.e., IL-4, IL-5 and IL-13 as well as type 2 immune cells including alternatively activated macrophages, innate lymphoid cells and Th2 cells. However, the hallmark characteristic of fil...
Source: Frontiers in Immunology - October 31, 2022 Category: Allergy & Immunology Source Type: research
Acquired lymphedema: Molecular contributors and future directions for developing intervention strategies
Lymphedema is a debilitating chronic disease that mostly develops as an adverse reaction to cancer treatment modalities such as chemotherapy, surgery, and radiotherapy. Lymphedema also appears to be a deteriorating consequence of roundworm infections, as best represented by filariasis. According to its origin, lymphedema is classified as primary lymphedema and acquired lymphedema. The latter is an acquired condition that, hitherto, received a considerably low attention owing to the less number of fatal cases been reported. Notably, despite the low mortality rate in lymphedema, it has been widely reported to reduce the dise...
Source: Frontiers in Pharmacology - October 25, 2022 Category: Drugs & Pharmacology Source Type: research
Iron deficiency and soil-transmitted helminth infection: classic and neglected connections
Parasitol Res. 2022 Oct 19. doi: 10.1007/s00436-022-07697-z. Online ahead of print.ABSTRACTBeyond participating in the oxygen transport by red blood cells, iron is an essential micronutrient and contributes to different physiological pathways and processes, such as cell proliferation, DNA repair, and other homeostatic functions. Iron deficiency affects millions of people, especially children and pregnant women. The consequences of iron deficiency are diverse, including inadequate child development, impaired cognition, and reduced productivity. Several factors contribute to iron deficiency, such as iron-poor diet, genetic f...
Source: Cell Research - October 18, 2022 Category: Cytology Authors: Joel Henrique Ellwanger Marina Ziliotto Bruna Kulmann-Leal Jos é Artur Bogo Chies Source Type: research
Thermal proteome profiling reveals Haemonchus orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868
Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. The control of these parasites relies heavily on anthelmintic therapy, but treatment failures and resistance to these drugs are widespread. As efforts to develop vaccines against parasitic nematodes have been largely unsuccessful, there is an increased focus on discovering new anthelmintic entities to combat drug resistant worms. Here, we employed thermal proteome profiling (TPP) to explore hit pharmacology and to support optimisation of a hit compound (UMW-868), identified in a high-throughput w...
Source: Frontiers in Pharmacology - October 14, 2022 Category: Drugs & Pharmacology Source Type: research
Physiological insight into the conserved properties of Caenorhabditis elegans acid-sensing DEG/ENaCs
This article is protected by copyright. All rights reserved.PMID:36200489 | DOI:10.1113/JP283238 (Source: The Journal of Physiology)
Source: The Journal of Physiology - October 6, 2022 Category: Physiology Authors: Eva Kaulich Patrick T N McCubbin William R Schafer Denise S Walker Source Type: research
Physiological insight into the conserved properties of Caenorhabditis elegans acid-sensing DEG/ENaCs
This article is protected by copyright. All rights reserved.PMID:36200489 | DOI:10.1113/JP283238 (Source: The Journal of Physiology)
Source: The Journal of Physiology - October 6, 2022 Category: Physiology Authors: Eva Kaulich Patrick T N McCubbin William R Schafer Denise S Walker Source Type: research
Faunal change over 3 decades to reveal Rotundocollarette capoori n.gen., n.sp., a unique anisakid from Johnius dussumieri from the Central west coast of India at Goa
AbstractA unique anisakid roundworm,Rotundocollarette capoori n. gen., n.sp. infestingJohnius dussumieri from the Central West coast of India at Goa has been described. The worms are typically characterized by a cephalic collarette, a muscular collarette in post-caudal zone, intestinal caecum and a ventricular appendix. 3 pores, a part of cephalic infrastructure –a dorsal oral aperture, a dorso-laterally placed genital pore, and a sub-ventral excretory pore, at the junction of the bases of the 2 ventro-lateral lips, were typically unique as revealed by SEM studies. A pair of large squarish teeth flanked each of these thr...
Source: Journal of Parasitic Diseases - October 3, 2022 Category: Parasitology Source Type: research
