Worms Aren ’ t So Dumb
BY KIM BELLARD
Chances are, you’ve read about AI lately. Maybe you’ve actually even tried DALL-E or ChatGPT, maybe even GPT-4. Perhaps you can use the term Large Language Model (LLM) with some degree of confidence. But chances are also good that you haven’t heard of “liquid neural networks,” and don’t get the worm reference above.
That’s the thing about artificial intelligence: it’s evolving faster than we are. Whatever you think you know is already probably out-of-date.
Liquid neural networks were first introduced in 2020. The authors wrote: “We introduce a new class of time-continu...
Source: The Health Care Blog - April 26, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech Kim Bellard Liquid Neural Networks Worms Source Type: blogs
Fight Aging! Newsletter, April 3rd 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Tradeoff of Working with Short-Lived Laboratory Species
It is cheaper and faster to study aging - and potential approaches to treat aging - in short-lived species. The disadvantage is that much of what is learned and achieved will be irrelevant to aging as it occurs in longer-lived species such as our own. The response to calorie restriction, an upregulation of cellular housekeeping mechanisms that lengthens life, fortunately evolved early on in the development of life, and the biochemistry is surprisingly consistent even across widely divergent species. Thus much can be learned of it in lower animals with short life spans. Unfortunately, it turns out that this class of interve...
Source: Fight Aging! - March 29, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Answer to Case 684
Answer to theParasite Case of the Week 684: Anisakid L3 larvaeThe following is our third and final discussion from our amazing guest author and 3rd year medical student, Hadel Go. I ' m sure you will all agree that her discussions have been among the best we ' ve ever had on this blog. Congratulations on the excellent work, Hadel!_____________________ Worm cases are always my favorite because the comments are either “They are so beautiful!!” (@Parasite_Power on Twitter) or “…That’s a wholelottanope” (Valmik in the comments).This is a nematode in the Anisakidae family, likelyPseudoterranovaorAnisakis spp., ...
Source: Creepy Dreadful Wonderful Parasites - May 30, 2022 Category: Parasitology Source Type: blogs
Career Conversations: Q & A with Neuroimmunology Researcher Jingru Sun
Dr. Jingru Sun. Credit: Cori Kogan.
“If you want to pursue a career in science, it’s very important to foster a hardworking attitude, a creative mind, and critical thinking,” says Jingru Sun, Ph.D., an associate professor of translational medicine and physiology at Washington State University’s Elson S. Floyd College of Medicine in Spokane. Our interview with Dr. Sun highlights how her career path led her to research the way the nervous system regulates immune responses.
Q: How did you become interested in science?
A: In high school, I had an amazing teacher who introduced me to the scientific world, guide...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 9, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Injury and Illness Profiles Source Type: blogs
Fight Aging! Newsletter, January 31st 2022
In conclusion, the effects of MR on the gut barrier were likely related to alleviation of the oscillations of inflammation-related microbes. MR can enable nutritional intervention against age-related gut barrier dysfunction.
Clearing Senescent Cells from the Neural Stem Cell Niche Rapidly Improves Neurogenesis in Old Mice
https://www.fightaging.org/archives/2022/01/clearing-senescent-cells-from-the-neural-stem-cell-niche-rapidly-improves-neurogenesis-in-old-mice/
Neurogenesis is the generation of new neurons in the brain, and their integration into existing neural circuits. It is essential to learning a...
Source: Fight Aging! - January 30, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Digging Deeper into Ribosomal Dysfunction in Aging
A ribosome performs the translation portion of the process of gene expression, assembling protein molecules from amino acid building blocks according to the blueprint provided by messenger RNA molecules. The more efficiently a ribosome operates, the better a cell functions. Like all cellular components, the ribosome is negatively impacted by age, leading to a greater rate of errors in protein manufacture. The causes of this decline are not well understood, at least when it comes to drawing a clear line of causation back to the root causes of aging. It is perhaps noteworthy that long-lived naked mole rats have evolved unusu...
Source: Fight Aging! - January 26, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 27th 2021
This study provides causal evidence of a lipoprotein-Aß /capillary axis for onset and progression of a neurodegenerative process.
The Staggering Ongoing Cost of Failing to Aggressively Pursue the Development of Rejuvenation Therapies
https://www.fightaging.org/archives/2021/09/the-staggering-ongoing-cost-of-failing-to-aggressively-pursue-the-development-of-rejuvenation-therapies/
No feasible amount of funding that could be devoted to the research and development of rejuvenation therapies would be too much. If near all other projects were dropped, and institutions radically retooled on a short term basi...
Source: Fight Aging! - September 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Small Change in the Ribosome Reduces Protein Synthesis Errors and Modestly Extends Lifespan in Short-Lived Species
The ribosome is a cellular structure responsible for the translation stage of protein manufacture, in which proteins are assembled from amino acids according to the blueprint provided by a messenger RNA molecule. In today's research materials, scientists report that a small change in a ribosomal protein, found in heat-tolerant organisms, has interesting effects when introduced into short-lived laboratory species via genetic engineering. The outcome is a reduction in the error rate for protein manufacture, an increased heat tolerance, and a modestly extended life span.
It is worth noting that life span increases of t...
Source: Fight Aging! - September 22, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Cool Images: Wondrous Worms
The tiny roundworm Caenorhabditis elegans is one of the most common research organisms—creatures scientists use to study life. While C. elegans may seem drastically different from humans, it shares many genes and molecular pathways with us. Viewed with a microscope, the worm can also be surprisingly beautiful. Aside from the stunning imagery, these examples from our Image and Video Gallery show how C. elegans helps scientists advance our understanding of living systems and find new ways to improve our health.
Credit: Keir Balla and Emily Troemel, University of California San Diego.
This C. elegans has b...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 30, 2021 Category: Research Authors: Susan Johnson Tags: Cells Cool Creatures Cool Images Research Organisms Source Type: blogs
Teaching Old Cells New Tricks: Insights Into Molecular-Level Aging
When someone mentions aging, you may think of visible changes, like graying hair. Scientists can see signs of aging in cells, too. Understanding how basic cell processes are involved in aging is a first step to help people lead longer, healthier lives. NIGMS-funded researchers are discovering how aging cells change and applying this knowledge to health care.
Discovering the Wisdom of Worms
C. elegans with a ribosomal protein glowing red and muscle fibers glowing green. Credit: Hannah Somers, Mount Desert Island Biological Laboratory.
Aric Rogers, Ph.D., and Jarod Rollins, Ph.D., assistant professors of regenerati...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 2, 2020 Category: Research Authors: Chrissa Chverchko Tags: Injury and Illness Cellular Processes Research Roundup Source Type: blogs
Answer to Case 604
Answer toParasite Case of the Week 604: Plant material, not a parasite. Although the large size and round shape in section superficially resembles a cross-section of a large roundworm (i.e.,Ascaris lumbricoides), there are some key features that allow us to identify this as plant material. As nicely stated by Florida Fan, " There does not seem to be a layer of polymyarian muscle cells as well as the other anatomical components such as a digestive tube or reproductive organs and no excretory organs either " which would be seen inAscaris lumbricoides.He also adds: " when magnified enough we can see polygonal cells...
Source: Creepy Dreadful Wonderful Parasites - August 31, 2020 Category: Parasitology Source Type: blogs
Fight Aging! Newsletter, July 20th 2020
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons.
Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. This...
Source: Fight Aging! - July 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Overactive Immune System Protects Against Infection at the Cost of More Rapid Aging
Greater immune activity implies greater inflammation, which has a negative impact on tissue function if maintained over time. In aging, a great deal of damage is done by the chronic inflammation of an overactive immune system. Researchers here provide evidence to indicate that the evolved state of immunity is a balancing act between a faster pace of aging on the one hand, resulting from an immune system that is more active, and vulnerability to infection on the other, resulting from an immune system that is less active.
As we age, the immune system gradually becomes impaired. One aspect of this impairment is chron...
Source: Fight Aging! - July 17, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Answer to Case 596
Answer toParasite Case of the Week 596: Plant material; likely plant epidermis from leafy material. There appears to be a cuticle present, and part of an epidemal cell layer attached.There are several nice images of dichotomous leaf epidemal structureHERE. Mary Parker, a botanist, noted that " in aqueous conditions, I would expect an epidermal layer to curl with the cuticle inwards (which is the case in the images) as the cuticle is waterproof and doesn ' t swell, whereas the epidermal cells would be hydrated and expand forcing the layer into a spiral. " Thank you Mary for your valuable input! Mary has also provided ...
Source: Creepy Dreadful Wonderful Parasites - June 21, 2020 Category: Parasitology Source Type: blogs
