Fight Aging! Newsletter, April 27th 2020
In conclusion, our study demonstrated that Nrf2 deficiency promoted the increasing trend of autophagy during aging in skeletal muscle. Nrf2 deficiency and increasing age may cause excessive autophagy in skeletal muscle, which can be a potential mechanism for the development of sarcopenia.
To What Degree is Chondrocyte Hypertrophy in Osteoarthritis Due to Cellular Senescence?
https://www.fightaging.org/archives/2020/04/to-what-degree-is-chondrocyte-hypertrophy-in-osteoarthritis-due-to-cellular-senescence/
Senescent cells are large. They do not replicate, that function is disabled, but it is as if they go...
Source: Fight Aging! - April 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Speculating on Circumstances in Which Group Selection of Aging Can Occur
The consensus view on the evolution of aging is that it is a consequence of a race to the bottom in terms of competition for early life reproductive success. The result is mechanisms and systems that aid early fitness at the cost of later dysfunction - and consequent aging and death. This is known as the antagonistic pleiotropy hypothesis. So we exist, do pretty well at the outset of life, but are equipped with a biochemistry that is incapable of repairing itself well enough for the long term. Some metabolic byproducts cannot be broken down, and accumulate to cause issues. The adaptive immune system must store information,...
Source: Fight Aging! - April 24, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 10th 2020
In conclusion, the concept of an epigenetic clock is compelling, but caution should be taken in interpreting associations with age acceleration. Association tests of age acceleration should include age as a covariate.
A Discussion of Recent Work on Allotopic Expression of Mitochondrial Genes at the SENS Research Foundation
https://www.fightaging.org/archives/2020/02/a-discussion-of-recent-work-on-allotopic-expression-of-mitochondrial-genes-at-the-sens-research-foundation/
A paper published last month outlines recent progress on allotopic expression of mitochondrial genes carried out by the SENS Research...
Source: Fight Aging! - February 9, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing Efforts to Develop NAD+ Therapies to Reverse Age-Related Loss of Mitochondrial Function
Increasing levels of NAD+ in mitochondria, is a class of therapy that probably produces most of its benefits in animal models and human trials by restoring mitophagy. This may well be true of mitochondrially targeted antioxidants as well. Mitophagy removes damaged mitochondria, but is hampered by age-related changes in mitochondrial dynamics, among other reasons. Mitochondria are responsible for packaging chemical energy store molecules to power cellular operations. Mitochondrial function is critical to tissue function throughout the body, but is of particular note in the energy-hungry tissues of muscle and brain.
N...
Source: Fight Aging! - February 7, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 16th 2019
This study shows that CA are released from periventricular and subpial regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that m...
Source: Fight Aging! - December 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Variation in Early Life Stress Contributes to Differences in Lifespan in Genetically Identical Worms
Why do genetically identical nematode worms raised in the same environment exhibit a distribution in life span? Researchers here suggest that differences in oxidative stress in early life are an important contributing factor, perhaps steering metabolism in some of these simple organisms towards greater resistance to the rising oxidative stress of aging. So a form of hormetic effect, perhaps. Does this have much relevance to higher animals such as our own, however?
It would be challenging to separate out early life effects of this nature from the environmental differences across the whole of life, given the existing ...
Source: Fight Aging! - December 12, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Answer to Case 562
Answer toParasite Case of the Week 562: Likely anisakid, given the gross and microscopic appearance and position in the body. This also fits with the clinical history that I held back - this patient was an avid sushi lover!From the gross image, you can tell that this is a roundworm, and that it appears to be embedded in the gastric mucosa:You can also see that the caliber of the worm is similar throughout its length. That, as well as the location (stomach), makeTrichuris trichiuraunlikely. The longer length also allows us to rule outEnterobius vermicularisand the hookworms (which admittedly would also be unlikely in t...
Source: Creepy Dreadful Wonderful Parasites - September 29, 2019 Category: Parasitology Source Type: blogs
Fight Aging! Newsletter, August 26th 2019
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 25, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Popular Science Publications Struggle to Grasp the State of Aging Research
As a rule, the journalistic community struggles to correctly represent any complex situation, community, or state of affairs. It is outsiders writing on a topic they generally know little of, under a deadline, and with few to no consequences attending mistakes and misrepresentations. To a journalist, any field looks like a confusing bristle of self-promoters and high-profile figures, all of them contradicting one another on points that require a good amount of technical knowledge to understand. It is the blind men and the elephant wherein some of the blind men have book deals to promote, or companies to talk up, and most o...
Source: Fight Aging! - August 20, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Answer to Case 556
Answer to theParasite Case of the Week 556: Curschmann spiralsCurshmann spirals can be a very pretty, but sometimes confounding parasite mimic in sputum, BAL and bronchial lavage specimens. They are spiral-shaped plugs of mucus from obstructed bronchioles, and are seen in patients with asthma and other conditions affecting the airways (e.g. tracheobronchomalacia as seen in this case). Although they can take on a roundworm-like appearance, they can be differentiated by their lack of defined morphologic features such as a cuticle and internal structures. Here is a striking photo from a different case (Papanicolaou stain): (S...
Source: Creepy Dreadful Wonderful Parasites - August 11, 2019 Category: Parasitology Source Type: blogs
Psychologists Have Identified The Creatures We Find Most Scary And Revolting
via Polák et al, 2019
By Christian Jarrett
You may be best advised not to read this article late at night or before you eat. Psychologists at the National Institute of Mental Health and Charles University in the Czech Republic have surveyed a large sample of non-clinical volunteers to gauge their reaction to 24 creatures that are commonly the source of specific animals phobias.
The results, published in the British Journal of Psychology, not only contribute to our understanding of animal phobias, but could prove incredibly useful to horror writers. Among the key findings is that spiders were unique in being both intensely...
Source: BPS RESEARCH DIGEST - June 25, 2019 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Emotion evolutionary psych Mental health Source Type: blogs
Fight Aging! Newsletter, April 8th 2019
This study did not confirm the hypothesis that ELL individuals have lower polygenic risk scores for cardiovascular-related phenotypes. Only the HDL cholesterol and triglyceride PRS were nominally significantly associated with ELL participants. In contrast and as expected, ELL individuals had higher polygenic risk scores for exceptional longevity (EL). In regards to the associations of the various cardiovascular PRS with EL, no findings survived correction for multiple testing. This is despite validating the utility of the lipid PRS by confirming positive associations with measured lipid levels in our sample. Interestingly,...
Source: Fight Aging! - April 7, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Low Mitochondrial Permeability is Required for Autophagy to Extend Life Span
Mitochondria are the power plants of the cell, generating the chemical energy store molecule adenosine triphosphate (ATP) that powers cellular processes. Every cell possesses a herd of mitochondria, replicating like bacteria, and monitored by quality control mechanisms. Damaged, potentially harmful mitochondria are removed and dismantled for raw materials through a variant of autophagy called mitophagy. A mountain of evidence links mitochondrial function to aging, just as a mountain of evidence links the cellular recycling mechanisms of autophagy to aging. Both mitochondrial function and autophagic activity decline with ag...
Source: Fight Aging! - April 5, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 25th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - February 24, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Restoration of Lapsed Mitophagy as a Potential Treatment for Alzheimer's Disease
Many research groups have published evidence to suggest that age-related mitochondrial dysfunction is an important aspect of neurodegenerative conditions such as Alzheimer's disease. The brain is an energy-hungry organ and mitochondria are the power plants of the cell, responsible for producing the chemical energy store molecules that power cellular activity. It is well known that mitochondrial function declines with age; mitochondria in old tissues are structurally different, and less effective at their jobs.
The research results here suggest that this mitochondrial decline has a lot to do with the fact that the ce...
Source: Fight Aging! - February 21, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
