Methylphenidate for treating fatigue in palliative cancer care - effect and side effects in real-world data from a palliative care unit
CONCLUSION: Methylphenidate is generally effective and well-tolerated for the treatment of CRF in palliative care. However, patients with a short life expectancy (<4 weeks) seem to benefit less from the treatment regardless of age, cancer type and dose.PMID:38348853 | DOI:10.2340/1651-226X.2024.24156 (Source: Acta Oncologica)
Source: Acta Oncologica - February 13, 2024 Category: Cancer & Oncology Authors: Agneta Almerud Gabriella Frisk Caritha Klasson Linda Bj örkhem-Bergman Source Type: research
Prevalence of the use of prescription stimulants as “study drugs” by UK university students: A brief report
ConclusionThere is a clear need for large-scale research in this area, using representative sampling and survey methods that protect student anonymity. (Source: Brain and Behavior)
Source: Brain and Behavior - February 13, 2024 Category: Neurology Authors: Ffinian Jones,
Philip M. Newton Tags: BRIEF REPORT Source Type: research
A review of recent treatments for adults living with attention-deficit/hyperactivity disorder
Conclusion: Pharmacological and non-pharmacological approaches, as well as neurostimulation or a blend of these approaches were acknowledged as the most effective recent modalities in the treatment of adult ADHD.Contribution: This review reported on the most current approaches to treat adult ADHD. This will facilitate a better understanding and informed decisions with regard to dealing with adult ADHD. (Source: South African Journal of Psychiatry)
Source: South African Journal of Psychiatry - February 7, 2024 Category: Psychiatry Authors: Candice Wakelin, Michele Willemse, Erica Munnik Source Type: research
Perceived cognitive performance in off ‐prescription users of modafinil and methylphenidate: an online survey
ConclusionThese findings suggest that at least some reported off-prescription users of modafinil and methylphenidate may be seeking to reduce the impact of self-perceived poorer performance, particularly in forms of cognition that are likely to impact on self-directed or self-motivated work. (Source: Brain and Behavior)
Source: Brain and Behavior - February 5, 2024 Category: Neurology Authors: Rachel D. Teodorini,
Nicola Rycroft,
James H. Smith ‐Spark Tags: ORIGINAL ARTICLE Source Type: research
Child and Parent Mindfulness-Based Training Versus Medication for Childhood ADHD: A Randomised Clinical Trial
ConclusionsOverall, although mindfulness alone might not be sufficient for some families, family mindfulness training in general can be considered a non-pharmacological alternative or addition in the treatment of childhood ADHD.Preregistrationhttps://onderzoekmetmensen.nl/nl/trial/22179, 11.10.2013. (Source: Mindfulness)
Source: Mindfulness - February 3, 2024 Category: Psychiatry & Psychology Source Type: research
Giggle incontinence: a scoping review
Pediatr Res. 2024 Feb 2. doi: 10.1038/s41390-024-03065-y. Online ahead of print.ABSTRACTGiggle incontinence (GI) is poorly described, defined, and understood. It is considered a bladder storage disorder in which laughter causes an uncontrollable episode of urinary incontinence that cannot be stopped until the bladder is completely emptied. It has been confused with stress urinary incontinence and overactive bladder. A thorough analysis of 26 articles on the subject of "giggle incontinence" and associated terms was performed, including all articles since the phrase first appeared. To date, 351 GI cases have been reported. I...
Source: Pediatric Research - February 2, 2024 Category: Pediatrics Authors: Adri án A González-Maldonado Manuel Garc ía-Mérida Source Type: research
Efficacy of Methylphenidate for Internet Gaming Disorder and Internet Addiction in Patients with Attention-Deficit/Hyperactivity Disorder
CONCLUSION: This longitudinal prospective study contributes to the understanding of IGD/IA treatment in ADHD patients and highlights the importance of considering individual clinical characteristics when predicting treatment response. However, MPH may not directly impact IGD/IA symptom reduction.PMID:38299404 | DOI:10.2174/0113816128281014240124074845 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 1, 2024 Category: Drugs & Pharmacology Authors: Andrea Salvati Gianluca Sesso Francesca Lenzi Gabriele Masi Stefano Berloffa Source Type: research
Pharmacotherapy to Improve Cognitive Functioning After Acquired Brain Injury: A Meta-Analysis and Meta-Regression
Clin Pharmacol Ther. 2024 Jan 31. doi: 10.1002/cpt.3186. Online ahead of print.ABSTRACTCognitive impairments, common sequelae of acquired brain injury (ABI), significantly affect rehabilitation and quality of life. Currently, there is no solid evidence-base for pharmacotherapy to improve cognitive functioning after ABI, nevertheless off-label use is widely applied in clinical practice. This meta-analysis and meta-regression aims to quantitatively aggregate the available evidence for the effects of pharmacological agents used in the treatment of cognitive impairments following ABI. We conducted a comprehensive search of Emb...
Source: Clinical Pharmacology and Therapeutics - January 31, 2024 Category: Drugs & Pharmacology Authors: Ruud van der Veen Marsh K önigs Simon Bakker Andries van Iperen Saskia Peerdeman Pierre M Bet Jaap Oosterlaan Source Type: research
Emerging drugs for the treatment of irritability associated with autism spectrum disorder
Expert Opin Emerg Drugs. 2024 Jan 31:1-12. doi: 10.1080/14728214.2024.2313650. Online ahead of print.ABSTRACTINTRODUCTION: Autism spectrum disorder (ASD) is an early-onset disorder with a prevalence of 1% among children and reported disability-adjusted life years of 4.31 million. Irritability is a challenging behavior associated with ASD, for which medication development has lagged. More specifically, pharmacotherapy effectiveness may be limited against high adverse effects (considering side effect profiles and patient medication sensitivity); thus, the possible benefits of pharmacological interventions must be balanced ag...
Source: Expert Opinion on Emerging Drugs - January 31, 2024 Category: Drugs & Pharmacology Authors: Ahmad Shamabadi Hanie Karimi Razman Arabzadeh Bahri Mohsen Motavaselian Shahin Akhondzadeh Source Type: research
Improving Methylphenidate Titration in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): A Randomized Controlled Trial Using Placebo-Controlled Titration Implemented in Clinical Practice
CONCLUSIONS: PCT can be used to improve detection of children who do not benefit from MPH, and may therefore potentially reduce overtreatment of ADHD with MPH.PMID:38280943 | DOI:10.1007/s40272-023-00604-8 (Source: Paediatric Drugs)
Source: Paediatric Drugs - January 27, 2024 Category: Pediatrics Authors: Karen Vertessen Marjolein Luman Pierre Bet Catharina E Bergwerff Marco Bottelier Reino Stoffelsen James M Swanson Annemiek Wisse Jos Twisk Jaap Oosterlaan Source Type: research
Improving Methylphenidate Titration in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): A Randomized Controlled Trial Using Placebo-Controlled Titration Implemented in Clinical Practice
ConclusionsPCT can be used to improve detection of children who do not benefit from MPH, and may therefore potentially reduce overtreatment of ADHD with MPH. (Source: Pediatric Drugs)
Source: Pediatric Drugs - January 27, 2024 Category: Pediatrics Source Type: research
Development of a novel rodent rapid serial visual presentation task reveals dissociable effects of stimulant versus nonstimulant treatments on attentional processes
This study developed a novel touchscreen task for rats based on the structure of a human RSVP task and used pharmacological manipulations to investigate their effects on different performance measures. Normal animals were trained to respond to a target image and withhold responding to distractor images presented within a continuous sequence. In a second version of the task, a false-alarm image was included, so performance could be assessed relative to two types of nontarget distractors. The effects of acute administration of stimulant and nonstimulant treatments for ADHD (amphetamine and atomoxetine) were tested in both ta...
Source: Cognitive, Affective and Behavioral Neuroscience - January 22, 2024 Category: Neuroscience Authors: Abigail Benn Emma S J Robinson Source Type: research
Evaluation of corneal endothelial cell morphology off and on treatment by specular microscopy in children and adolescents with attention deficit hyperactivity disorder
CONCLUSION: Methylphenidate treatment administered for at least six months with a diagnosis of ADHD did not have a toxic effect on the corneal endothelium.PMID:38235962 | DOI:10.1080/15569527.2024.2303442 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - January 18, 2024 Category: Toxicology Authors: Hakan Koc Bedia Sultan Önal Esra Ho şoğlu Source Type: research
Comprehensive metabolic investigation of dopamine reuptake inhibitor HDMP ‐28 in equine liver microsomes and Cunninghamella elegans for doping control
This study explores the metabolic conversion of HDMP-28 mediated by equine liver microsomes andCunninghamella elegans. An extraction and detection method was developed, optimized, and validated for doping assessment in equine urine and plasma. Liquid chromatography –high-resolution mass spectrometry was employed to determine metabolite structures. The study identified 31 (22 phase I and 9 phase II) metabolites of HDMP-28, including hydroxylated, hydrogenated, and hydrolyzed analogs. Glucuronic acid-conjugated metabolites were also detected. This manuscript d escribes metabolites based on the in vitro studies, which might...
Source: Drug Testing and Analysis - January 16, 2024 Category: Drugs & Pharmacology Authors: Meleparappil Muhammed Ajeebsanu,
Michael Benedict Subhahar,
Abdul Khader Karakka Kal,
Moses Philip,
Zubair Perwad,
Tajudheen Kunhamu Karatt,
Fatma Mohammed Graiban,
Marina Joseph,
Shantymol V. Jose Tags: RESEARCH ARTICLE Source Type: research
