Genotoxic and genoprotective effects of some antipsychotic drugs, methylphenidate and atomoxetine on human lymphocytes and HepG2 cells
CONCLUSIONS: As a result, the genotoxicity of the drugs was found to be dose-dependent, and all drugs showed a genoprotective effect on DNA-damaged cells.PMID:38436168 | DOI:10.26355/eurrev_202402_35456 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 4, 2024 Category: Drugs & Pharmacology Authors: S K Sezer S Yuksel I Ucuz Source Type: research
Genotoxic and genoprotective effects of some antipsychotic drugs, methylphenidate and atomoxetine on human lymphocytes and HepG2 cells
CONCLUSIONS: As a result, the genotoxicity of the drugs was found to be dose-dependent, and all drugs showed a genoprotective effect on DNA-damaged cells.PMID:38436168 | DOI:10.26355/eurrev_202402_35456 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 4, 2024 Category: Drugs & Pharmacology Authors: S K Sezer S Yuksel I Ucuz Source Type: research
Genotoxic and genoprotective effects of some antipsychotic drugs, methylphenidate and atomoxetine on human lymphocytes and HepG2 cells
CONCLUSIONS: As a result, the genotoxicity of the drugs was found to be dose-dependent, and all drugs showed a genoprotective effect on DNA-damaged cells.PMID:38436168 | DOI:10.26355/eurrev_202402_35456 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 4, 2024 Category: Drugs & Pharmacology Authors: S K Sezer S Yuksel I Ucuz Source Type: research
Neurexin1 α knockout in rats causes aberrant social behaviour: relevance for autism and schizophrenia
ConclusionDeletion of the neurexin1 α gene in rats causes exaggerated social play, which is not modified by social play deprivation. This phenotype therefore resembles disinhibited behaviour rather than the social withdrawal seen in ASD and SCZ. The neurexin1α knockout rat could be a model for inappropriate or disinhibited social be haviour seen in childhood mental disorders. (Source: Psychopharmacology)
Source: Psychopharmacology - February 29, 2024 Category: Psychiatry Source Type: research
AACAP Endorses the Inclusion of Methylphenidate in the WHO Model Lists of Essential Medicines
The World Health Organization (WHO) essential medicines list (EML) includes a list of minimum medicine needs for a basic health-care system, listing the most efficacious, safe, and cost-effective medicines for priority conditions. Priority conditions are selected on the basis of current and estimated future public health relevance, and potential for safe and cost-effective treatment. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - February 27, 2024 Category: Psychiatry Authors: Samuele Cortese, David Coghill, Gregory W. Mattingly, Luis Augusto Rohde, Robyn P. Thom, Timothy E. Wilens, Ian C.K. Wong, Stephen V. Faraone Tags: Letter to the Editor Source Type: research
Association of Age and Response to Methylphenidate HCL Treatment in Adult ADHD: A Proton Magnetic Resonance Spectroscopy Study
(Source: Neuropsychiatric Disease and Treatment)
Source: Neuropsychiatric Disease and Treatment - February 20, 2024 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
