Evaluation of corneal endothelial cell morphology off and on treatment by specular microscopy in children and adolescents with attention deficit hyperactivity disorder
CONCLUSION: Methylphenidate treatment administered for at least six months with a diagnosis of ADHD did not have a toxic effect on the corneal endothelium.PMID:38235962 | DOI:10.1080/15569527.2024.2303442 (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - January 18, 2024 Category: Toxicology Authors: Hakan Koc Bedia Sultan Önal Esra Ho şoğlu Source Type: research
Comprehensive metabolic investigation of dopamine reuptake inhibitor HDMP ‐28 in equine liver microsomes and Cunninghamella elegans for doping control
This study explores the metabolic conversion of HDMP-28 mediated by equine liver microsomes andCunninghamella elegans. An extraction and detection method was developed, optimized, and validated for doping assessment in equine urine and plasma. Liquid chromatography –high-resolution mass spectrometry was employed to determine metabolite structures. The study identified 31 (22 phase I and 9 phase II) metabolites of HDMP-28, including hydroxylated, hydrogenated, and hydrolyzed analogs. Glucuronic acid-conjugated metabolites were also detected. This manuscript d escribes metabolites based on the in vitro studies, which might...
Source: Drug Testing and Analysis - January 16, 2024 Category: Drugs & Pharmacology Authors: Meleparappil Muhammed Ajeebsanu,
Michael Benedict Subhahar,
Abdul Khader Karakka Kal,
Moses Philip,
Zubair Perwad,
Tajudheen Kunhamu Karatt,
Fatma Mohammed Graiban,
Marina Joseph,
Shantymol V. Jose Tags: RESEARCH ARTICLE Source Type: research
Limited usefulness of neurocognitive functioning indices as predictive markers for treatment response to methylphenidate or neurofeedback@home in children and adolescents with ADHD
DiscussionCurrent findings indicate a potential value of self-report (BRIEF global score) and some objectively measured neurocognitive indices (CPT commission errors and hit reaction time variability) as treatment markers (of change) for MPH. However, we found a rather limited prognostic value with regard to predicting treatment response not (yet) allowing recommendation for clinical use. Baseline symptom severity was revealed as the most relevant predictor, replicating robust findings from previous studies. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - January 12, 2024 Category: Psychiatry Source Type: research
Methylphenidate for neurological improvement post-TBI
J Family Med Prim Care. 2023 Nov;12(11):2987-2989. doi: 10.4103/jfmpc.jfmpc_326_23. Epub 2023 Nov 21.ABSTRACTTraumatic brain injuries (TBIs) can have numerous neurologic and cognitive sequelae. The road to recovery can be long and arduous for many patients. Improving cognition can assist in a shorter recovery time as patients may be more in tune with their plan of care. Family physicians may be helpful in assisting with the recovery process post-hospital discharge. This case report seeks to educate family physicians on the use of methylphenidate in the ambulatory setting after TBI. Here, a case of a 51-year-old man on meth...
Source: Primary Care - January 8, 2024 Category: Primary Care Authors: Denelle Mohammed Sadhika Verma Source Type: research
Is cognitive behavioral therapy more effective than pharmacotherapy for binge spectrum disorders? A systematic review and meta-analysis
CONCLUSIONS: Data are scarce, comparisons underpowered and, considering the inherent methodological limitations of psychotherapy trials, questions arise regarding the presumed superiority of cognitive behavioral therapy. Further research is needed.PMID:38179705 | DOI:10.1177/00048674231219593 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - January 5, 2024 Category: Psychiatry Authors: Myrto T Samara Niki Michou Andreas S Lappas Aikaterini Argyrou Elissavet Mathioudaki Dimitra Rafailia Bakaloudi Eirini Tsekitsidi Zoi A Polyzopoulou Nikos Christodoulou Georgios Papazisis Michail Chourdakis Source Type: research
Is cognitive behavioral therapy more effective than pharmacotherapy for binge spectrum disorders? A systematic review and meta-analysis
CONCLUSIONS: Data are scarce, comparisons underpowered and, considering the inherent methodological limitations of psychotherapy trials, questions arise regarding the presumed superiority of cognitive behavioral therapy. Further research is needed.PMID:38179705 | DOI:10.1177/00048674231219593 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - January 5, 2024 Category: Psychiatry Authors: Myrto T Samara Niki Michou Andreas S Lappas Aikaterini Argyrou Elissavet Mathioudaki Dimitra Rafailia Bakaloudi Eirini Tsekitsidi Zoi A Polyzopoulou Nikos Christodoulou Georgios Papazisis Michail Chourdakis Source Type: research
Is cognitive behavioral therapy more effective than pharmacotherapy for binge spectrum disorders? A systematic review and meta-analysis
CONCLUSIONS: Data are scarce, comparisons underpowered and, considering the inherent methodological limitations of psychotherapy trials, questions arise regarding the presumed superiority of cognitive behavioral therapy. Further research is needed.PMID:38179705 | DOI:10.1177/00048674231219593 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - January 5, 2024 Category: Psychiatry Authors: Myrto T Samara Niki Michou Andreas S Lappas Aikaterini Argyrou Elissavet Mathioudaki Dimitra Rafailia Bakaloudi Eirini Tsekitsidi Zoi A Polyzopoulou Nikos Christodoulou Georgios Papazisis Michail Chourdakis Source Type: research
Is cognitive behavioral therapy more effective than pharmacotherapy for binge spectrum disorders? A systematic review and meta-analysis
CONCLUSIONS: Data are scarce, comparisons underpowered and, considering the inherent methodological limitations of psychotherapy trials, questions arise regarding the presumed superiority of cognitive behavioral therapy. Further research is needed.PMID:38179705 | DOI:10.1177/00048674231219593 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - January 5, 2024 Category: Psychiatry Authors: Myrto T Samara Niki Michou Andreas S Lappas Aikaterini Argyrou Elissavet Mathioudaki Dimitra Rafailia Bakaloudi Eirini Tsekitsidi Zoi A Polyzopoulou Nikos Christodoulou Georgios Papazisis Michail Chourdakis Source Type: research
Protocol of a monocentric, double-blind, randomized, superiority, controlled trial evaluating the effect of in-prison OROS-methylphenidate vs. placebo treatment in detained people with attention-deficit hyperactivity disorder (BATIR)
Attention-deficit hyperactivity disorder (ADHD) is characterized by difficulty paying attention, poor impulse control, and hyperactive behavior. It is associated with several adverse health and social outcomes... (Source: Trials)
Source: Trials - January 4, 2024 Category: General Medicine Authors: St éphanie Baggio, Joël Billieux, Anja Dirkzwager, Katia Iglesias, Karine Moschetti, Nader Perroud, Marie Schneider, Nathalie Vernaz, Hans Wolff and Patrick Heller Tags: Study protocol Source Type: research
Comparison of neuroprotective effects of a topiramate-loaded biocomposite based on mesoporous silica nanoparticles with pure topiramate against methylphenidate-induced neurodegeneration
CONCLUSION: TPM-loaded nanoparticles could be used as neuroprotective agents against MPH-induced neurodegeneration by improving seizure parameters and reducing inflammatory, oxidant, and apoptotic factors.PMID:38170306 | DOI:10.1007/s11033-023-09011-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 3, 2024 Category: Molecular Biology Authors: Erfan Pari Mohammad Sheibani Mohammad Reza Sazegar Saeedeh Mir Ashrafsadat Moazam Mina Khalilzadeh Manijeh Motevalian Source Type: research
Comparison of neuroprotective effects of a topiramate-loaded biocomposite based on mesoporous silica nanoparticles with pure topiramate against methylphenidate-induced neurodegeneration
CONCLUSION: TPM-loaded nanoparticles could be used as neuroprotective agents against MPH-induced neurodegeneration by improving seizure parameters and reducing inflammatory, oxidant, and apoptotic factors.PMID:38170306 | DOI:10.1007/s11033-023-09011-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 3, 2024 Category: Molecular Biology Authors: Erfan Pari Mohammad Sheibani Mohammad Reza Sazegar Saeedeh Mir Ashrafsadat Moazam Mina Khalilzadeh Manijeh Motevalian Source Type: research
Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task
ConclusionsNL3R451C mice demonstrated intact attention orienting but altered responses to the pharmacological manipulation of the dopaminergic and noradrenergic networks. These findings expand our understanding of the NL3R451C mutation by suggesting that this mutation may lead to selective alterations in attentional processes. (Source: Psychopharmacology)
Source: Psychopharmacology - January 3, 2024 Category: Psychiatry Source Type: research
Methylphenidate attenuates signs of evoked neuropathic pain in animal model
Physiol Res. 2023 Dec 29;72(S5):S551-S558.ABSTRACTMethylphenidate is a psychostimulant that increases dopamine and noradrenaline levels. Recent studies have shown that methylphenidate potentiates the effect of morphine and together suppress acute and chronic pain. In clinical practice, methylphenidate has been used as a treatment for ADHD and changes of pain threshold have been noted in these patients. The aim of this study was to determine the effect of methylphenidate in an animal model of peripheral neuropathic pain. Neuropathic pain was modeled by the chronic constriction of the sciatic nerve (CCI) in Wistar rats. We e...
Source: Physiological Research - January 2, 2024 Category: Physiology Authors: K Panu šková L Vod ěrová Š Vaculín Source Type: research
