A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
A new mechanistic insight into the association between environmental perfluorooctane sulfonic acid (PFOS) exposure and attention deficit and hyperactivity disorder (ADHD)-like behavior
This study enriches our understanding of the pathogenic mechanisms underlying ADHD development and emphasizes the importance of focusing on the health risks pertaining to environmental exposure.PMID:37952603 | DOI:10.1016/j.neuro.2023.11.004 (Source: Neurotoxicology)
Source: Neurotoxicology - November 12, 2023 Category: Neurology Authors: Miao Zhang Xueyan Gu Liu Wu Nannan Wan Yu Liu Zaijun Xin Tianbing Chen Shuai Liu Mingqi Li Mi Deng Qiyu Wang Source Type: research
Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice
Biomed Pharmacother. 2023 Nov 8;169:115860. doi: 10.1016/j.biopha.2023.115860. Online ahead of print.ABSTRACTIntracranial self-stimulation (ICSS) of the medial forebrain bundle in mice is an experimental model use to assess the relative potential of reward-seeking behaviors. Here, we used the ICSS model to evaluate the abuse potential of 18 abused drugs: 3-Fluoroethamphetamine (3-FEA); methylphenidate; cocaine; dextroamphetamine; alpha-Pyrrolidinobutyrophenone (α-PBT); 4'-Fluoro-4-methylaminorex (4-FPO); methamphetamine; larocaine; phentermine; paramethoxymethamphetamine (PMMA); phendimetrazine; N-(1-adamantyl)-1-pentyl-1...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 10, 2023 Category: Drugs & Pharmacology Authors: Yong-Qing Zhang Hyun Kyu Min Eunchong Hong Eunhye Yu Sun Mi Gu Seong Shoon Yoon Dohyun Lee Jaejun Lee Jin Tae Hong Jaesuk Yun Source Type: research
Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice
Biomed Pharmacother. 2023 Nov 8;169:115860. doi: 10.1016/j.biopha.2023.115860. Online ahead of print.ABSTRACTIntracranial self-stimulation (ICSS) of the medial forebrain bundle in mice is an experimental model use to assess the relative potential of reward-seeking behaviors. Here, we used the ICSS model to evaluate the abuse potential of 18 abused drugs: 3-Fluoroethamphetamine (3-FEA); methylphenidate; cocaine; dextroamphetamine; alpha-Pyrrolidinobutyrophenone (α-PBT); 4'-Fluoro-4-methylaminorex (4-FPO); methamphetamine; larocaine; phentermine; paramethoxymethamphetamine (PMMA); phendimetrazine; N-(1-adamantyl)-1-pentyl-1...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 10, 2023 Category: Drugs & Pharmacology Authors: Yong-Qing Zhang Hyun Kyu Min Eunchong Hong Eunhye Yu Sun Mi Gu Seong Shoon Yoon Dohyun Lee Jaejun Lee Jin Tae Hong Jaesuk Yun Source Type: research
A convolution ‐based in vitro‐in vivo correlation model for methylphenidate hydrochloride delayed‐release and extended‐release capsule
AbstractDelayed-release and extended-release methylphenidate hydrochloride (JORNAY PM ®) is a novel capsule formulation of methylphenidate hydrochloride, used to treat attention deficit hyperactivity disorder in patients 6 years and older. In this paper, we develop a Level A in vitro-in vivo correlation (IVIVC) model for extended-release methylphenidate hydrochloride to support p ost-approval manufacturing changes by evaluating a point-to-point correlation between the fraction of drug dissolved in vitro and the fraction of drug absorbed in vivo. Dissolution data from an in vitro study of three different release form...
Source: CPT: Pharmacometrics and Systems Pharmacology - November 1, 2023 Category: Drugs & Pharmacology Authors: Pawan Kumar Gupta,
Bev Incledon,
Jogarao V. S. Gobburu,
Roberto Gomeni Tags: ARTICLE Source Type: research
Medical Cannabis Legalization: No Contribution to Rising Stimulant
Rates in the USA
This study aimed to determine if MC legalization increased prescription
stimulant distribution.
Methods Information on the distribution of methylphenidate, amphetamine,
and lisdexamfetamine for 2006 to 2021 was extracted from the Drug Enforcement
Administration’s comprehensive database and the three-year
population-corrected slopes of stimulant distribution before and after MC
program implementation were compared.
Results We found a significant main effect of time
(p<0.001); however, contrary to the hypothesis, the sales status
of states...
Source: Pharmacopsychiatry - October 26, 2023 Category: Psychiatry Authors: Alexander, Garrett D. Cavanah, Luke R. Goldhirsh, Jessica L. Huey, Leighton Y. Piper, Brian J. Tags: Original Paper Source Type: research
A Convolution ‐based In Vitro‐In Vivo Correlation (IVIVC) Model for Methylphenidate Hydrochloride Delayed‐release and Extended‐release Capsule
(Source: CPT: Pharmacometrics and Systems Pharmacology)
Source: CPT: Pharmacometrics and Systems Pharmacology - October 21, 2023 Category: Drugs & Pharmacology Authors: Pawan Kumar Gupta,
Bev Incledon,
Jogarao V. S. Gobburu,
Roberto Gomeni Tags: ARTICLE Source Type: research
The following article for this Special Issue was published in a different issue. They can be found in their respective issue
Increased sperm deoxyribonucleic acid damage leads to poor embryo quality and subfertility of male rats treated with methylphenidate hydrochloride in adolescence.ANDR. 2022; 10(8): 1632 –1643.https://doi.org/10.1111/andr.13277 (Source: Andrology)
Source: Andrology - October 19, 2023 Category: Urology & Nephrology Tags: ORIGINAL ARTICLE Source Type: research
Viloxazine extended-release capsules for the treatment of attention-deficit/ hyperactivity disorder in adult patients
Expert Rev Neurother. 2023 Oct 17:1-9. doi: 10.1080/14737175.2023.2265068. Online ahead of print.ABSTRACTINTRODUCTION: Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral disorder with symptoms that may persist in up to 90% of adults diagnosed during childhood and continue to cause significant impairment throughout the lifespan. In the United States (US), amphetamine and methylphenidate formulations have been available to treat ADHD for several decades. Only one nonstimulant, atomoxetine, was available for the treatment of ADHD in adults until recently. In April 2022, a second nonstimulant, viloxazi...
Source: Expert Review of Neurotherapeutics - October 17, 2023 Category: Neurology Authors: Ann Childress Robert Sottile Sherine Khanbijian Source Type: research
