Choosing the right biologic treatment for moderate-to-severe plaque psoriasis: the impact of comorbidities
Expert Rev Clin Pharmacol. 2024 Apr 11:1-17. doi: 10.1080/17512433.2024.2340552. Online ahead of print.ABSTRACTINTRODUCTION: Psoriasis is a chronic inflammatory skin disease often associated with several comorbidities, such as psoriatic arthritis, inflammatory bowel disease, obesity, diabetes mellitus or cardiovascular diseases, infections, or cancer, among others. With the progressive aging of the population, a growing number of patients with psoriasis can be expected to present multiple comorbidities. Currently, there is a wide range of biological treatments available for moderate to severe psoriasis, including tumor nec...
Source: Expert Review of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Laura L Mateu-Arrom Lluis L Puig Source Type: research
Choosing the right biologic treatment for moderate-to-severe plaque psoriasis: the impact of comorbidities
Expert Rev Clin Pharmacol. 2024 Apr;17(4):363-379. doi: 10.1080/17512433.2024.2340552. Epub 2024 Apr 11.ABSTRACTINTRODUCTION: Psoriasis is a chronic inflammatory skin disease often associated with several comorbidities, such as psoriatic arthritis, inflammatory bowel disease, obesity, diabetes mellitus or cardiovascular diseases, infections, or cancer, among others. With the progressive aging of the population, a growing number of patients with psoriasis can be expected to present multiple comorbidities. Currently, there is a wide range of biological treatments available for moderate to severe psoriasis, including tumor ne...
Source: Pharmacological Reviews - April 11, 2024 Category: Drugs & Pharmacology Authors: Laura Mateu-Arrom Lluis Puig Source Type: research
Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry
CONCLUSION: In the circulation of PsA patients, the TN and CD4+ TCM are characterized with more abundant CD28 and CD127, which effectively distinguished PsA from PsV. This may indicate that individuals undergoing PsV could be stratified at high risk of developing PsA based on the circulating levels of CD28 and CD127 on specific cell subsets.PMID:38590608 | PMC:PMC11001477 | DOI:10.1155/2024/9927964 (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Xudong Sang Tian Gan Gai Ge Dan Li Youming Mei Chun Pan Siyu Long Bibo Xie Xiaobing Yu Zhiming Chen Hongsheng Wang Source Type: research
Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry
CONCLUSION: In the circulation of PsA patients, the TN and CD4+ TCM are characterized with more abundant CD28 and CD127, which effectively distinguished PsA from PsV. This may indicate that individuals undergoing PsV could be stratified at high risk of developing PsA based on the circulating levels of CD28 and CD127 on specific cell subsets.PMID:38590608 | PMC:PMC11001477 | DOI:10.1155/2024/9927964 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 9, 2024 Category: Allergy & Immunology Authors: Xudong Sang Tian Gan Gai Ge Dan Li Youming Mei Chun Pan Siyu Long Bibo Xie Xiaobing Yu Zhiming Chen Hongsheng Wang Source Type: research
Janus kinase inhibitors and tumour necrosis factor inhibitors show a favourable safety profile and similar persistence in rheumatoid arthritis, psoriatic arthritis and spondyloarthritis: real-world data from the BIOBADASER registry
CONCLUSIONS: Infections, herpes zoster and gastrointestinal adverse events in patients with RA tended to be more frequent with JAKi. However, prognosis was poor in patients receiving JAKi. Persistence was similar for TNFi and JAKi, although factors associated with discontinuation differed by diagnostic group.PMID:38594056 | DOI:10.1136/ard-2023-225271 (Source: Herpes)
Source: Herpes - April 9, 2024 Category: Infectious Diseases Authors: Blanca Hern ández-Cruz Luc ía Otero-Varela Mercedes Freire-Gonz ález Noem í Busquets-Pérez Alfredo Javier Garc ía González Manuel Moreno-Ramos Juan Maria Blanco-Madrigal Sara Manrique-Arija Eva Perez-Pampin Dolores Ruiz-Montesino Fernando S ánchez Source Type: research
Circulating Immune Landscape Profiling in Psoriasis Vulgaris and Psoriatic Arthritis by Mass Cytometry
CONCLUSION: In the circulation of PsA patients, the TN and CD4+ TCM are characterized with more abundant CD28 and CD127, which effectively distinguished PsA from PsV. This may indicate that individuals undergoing PsV could be stratified at high risk of developing PsA based on the circulating levels of CD28 and CD127 on specific cell subsets.PMID:38590608 | PMC:PMC11001477 | DOI:10.1155/2024/9927964 (Source: Journal of Immunology Research)
Source: Journal of Immunology Research - April 9, 2024 Category: Allergy & Immunology Authors: Xudong Sang Tian Gan Gai Ge Dan Li Youming Mei Chun Pan Siyu Long Bibo Xie Xiaobing Yu Zhiming Chen Hongsheng Wang Source Type: research
Psoriasis and Molecular Target Therapies: Evidence of Efficacy in Preventing Cardiovascular Comorbidities
AbstractPsoriasis is now considered a systemic disease, and several comorbidities have been described such as cardiovascular diseases, neurologic and psychiatric disorders, chronic inflammatory bowel disease, psoriatic arthritis, etc. Regarding cardiovascular comorbidities, major adverse cardiovascular events have been reported in psoriasis patients by multiple epidemiologic studies. Moreover, smoking, obesity, metabolic syndrome, hypertension, dyslipidemia, diabetes and reduced physical activity are associated with psoriasis, increasing cardiovascular risk. Consequently, several aspects should be considered when making th...
Source: Dermatology and Therapy - April 9, 2024 Category: Dermatology Source Type: research
Clinical Characteristics of “Severe” Peripheral Psoriatic Arthritis: A Retrospective Analysis of a Longitudinal Cohort
ConclusionsOur study showed that severe patients with PsA had more disease activity, pain, and impact of disease than non-severe patients. Furthermore, we demonstrated that severity and disease activity are not interchangeable concepts. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - April 9, 2024 Category: Rheumatology Source Type: research
Psoriasis and Molecular Target Therapies: Evidence of Efficacy in Preventing Cardiovascular Comorbidities
AbstractPsoriasis is now considered a systemic disease, and several comorbidities have been described such as cardiovascular diseases, neurologic and psychiatric disorders, chronic inflammatory bowel disease, psoriatic arthritis, etc. Regarding cardiovascular comorbidities, major adverse cardiovascular events have been reported in psoriasis patients by multiple epidemiologic studies. Moreover, smoking, obesity, metabolic syndrome, hypertension, dyslipidemia, diabetes and reduced physical activity are associated with psoriasis, increasing cardiovascular risk. Consequently, several aspects should be considered when making th...
Source: Dermatology and Therapy - April 9, 2024 Category: Dermatology Source Type: research
Hematological indices in psoriatic enthesopathy: relation to clinical and ultrasound evaluation
ConclusionMonitoring PsA disease activity can be improved by considering RDW and MPV as reliable indicators and using them to screen for psoriatic enthesopathy with MSUS indices.Key points•Clinically identifying enthesitis in patients with PsA can be challenging. Imaging MSUS indices hold promise for objective analysis, but there is no consensus on which indices to use in clinical trials and daily practice.•Patients with psoriatic enthesopathy have higher RDW and MPV levels, which are positively correlated with DAPSA28 score.•RDW and MPV can be considered in the turn of improved screening of psoriatic enthesopathy...
Source: Clinical Rheumatology - April 8, 2024 Category: Rheumatology Source Type: research
Non-Pharmacological Interventions for Treating Psoriatic Arthritis
CONCLUSIONS: The polyhedral clinical expression of PsA underlines the need for a multidisciplinary approach combining the synergistic effects of pharmacological and non-pharmacological treatments. The latter range from preventive measures, like dietary modifications, weight loss, and cigarette smoking cessation, to personalized training protocols according to disease activity and phenotype, comorbidities, and individual tolerability. In these patients, we strongly encourage the regular practice of motor activity at progressively increasing intensity with combined supervised aerobic, strength, endurance, and stretching exer...
Source: Alternative Therapies in Health and Medicine - April 6, 2024 Category: Complementary Medicine Authors: Rossella Talotta Maria Rita Aiello Roberto Restuccia Ludovico Magaudda Source Type: research
