Humira Biosimilar Gross-to-Net Pricing Bubble Was Preceded by the Same Pricing Bubble Burst for Insulin Just Months Ago
Today ' s post is not about diabetes per se, although there IS a diabetes connection. But this morning, the big news was that a biosimilar of Abbvie ' s blockbuster anti-inflammatory biologic Humira will be sold byMark Cuban Cost Plus Drug Company (see the press release athttps://www.globenewswire.com/news-release/2023/06/01/2680351/33333/en/Mark-Cuban-Cost-Plus-Drug-Company-joins-forces-with-Coherus-to-make-YUSIMRY-a-HUMIRA-biosimilar-available-to-patients.html for more) at what amounts to an 85% discount to the innovator drug. Mark Cuban Cost Plus Drug Company announced the Humira biosimilar on social media today. See th...
Source: Scott's Web Log - June 1, 2023 Category: Endocrinology Tags: 2023 Abbvie Biosimilar drug discounts gross-to-net bubble Humira insulin Source Type: blogs
Neuroimmune Modulation for Inflammatory Disease: Interview with Dr. Simhambhatla, President and CEO of SetPoint Medical
SetPoint Medical, a medtech company based in California, is developing a neuromodulatory device that is intended to treat rheumatoid arthritis. The overlap between the nervous and immune systems is increasingly appreciated, and this technology aims to capitalize on this to create a new treatment for inflammatory disease.
The neuromodulation device is intended to be implanted on the left cervical vagus nerve in an outpatient procedure. It stimulates the nerve with electrical pulses. The idea is that this can act to calm inflammatory processes that contribute to rheumatoid arthritis, without the drawbacks of immunosuppres...
Source: Medgadget - February 28, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Medicine Neurology autoimmune immunology SetPointMed Source Type: blogs
Fight Aging! Newsletter, January 13th 2020
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - January 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Suppression of Neuroinflammation as a Treatment for Neurodegenerative Disease
There is a growing focus on inflammation in the brain as an important factor in the progression of neurodegenerative disease. One result is greater thought given to therapeutic strategies involving the suppression of inflammatory signaling, akin to the approaches used to control inflammatory autoimmune conditions such as rheumatoid arthritis. I would wager that this is probably not as good a strategy as removing senescent glial cells in the brain, and thus removing their sizable contribution to inflammatory signaling, given the animal data in support of that approach, but it will certainly be attempted in the years ahead.
...
Source: Fight Aging! - January 8, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
World Mental Health Day 2019: Letter to a Suicidal Person
By the time you read this blog, two or three people will have taken their lives. In fact, every 40 seconds someone completes suicide; Close to 800,000 die by suicide every year. According to the World Health Organization, there are more deaths from suicide than from war and homicide together. Suicide is the second leading cause of death between people ages 15 to 29.
These statistics don’t surprise me since I’ve lost two family members and several friends to suicide, and about one third of the people I know have lost a loved one to suicide. I am familiar with the desperation and rationale that leads someone to this deci...
Source: World of Psychology - October 10, 2019 Category: Psychiatry & Psychology Authors: Therese J. Borchard Tags: Depression Suicide World Mental Health Day Suicidal Thoughts Source Type: blogs
Does Calling Depression an Illness Worsen Stigma?
I plead guilty to expounding on the biochemical vulnerabilities and abnormalities in neural wiring of depression to make the case that it is a legitimate illness alongside lupus, breast cancer, or psoriatic arthritis. I thought I was doing a good thing by quoting experts like Peter Kramer, M.D, who believes that because depression can be associated with the loss of volume in parts of the brain, it is the “most devastating disease known to mankind.”
My intention, like so many other mental health advocates I know, was to use science as a tool to lessen stigma. But is that really effective?
Proof of the Madness
I am relie...
Source: World of Psychology - March 16, 2019 Category: Psychiatry & Psychology Authors: Therese J. Borchard Tags: Brain and Behavior Depression General Mental Health and Wellness Psychiatry Psychology Research Self-Help Treatment biogenetic theory Depressive Episode Mental Illness Mood Disorder Stereotypes Stigma Source Type: blogs
Ankylosing Spondylitis: MRI
DiscussionAnkylosing spondylitis (also known as Bechterew disease and Marie Str ümpell disease). More common in males with 3:1 ratio.Spondyloarthritis is a group of diseases with common clinical, laboratory, and genetic features& association with human leukocyte antigen HLA-B27. Ankylosing spondylitis is the prototypic disease in the spectrum of spondyloarthritis which usually has axial skeletal manifestations. Other representative disorders in this spectrum of disease which usually have peripheral articular involvement, but axial skeleton manifestations are also frequently seen are --psoriati...
Source: Sumer's Radiology Site - January 11, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
6 Life Lessons I Learned Last Year
Danish philosopher and theologian Søren Kierkegaard once wrote, “Life can only be understood backwards; but it must be lived forwards.” The beginning of a new year is an appropriate time to look back over the lessons learned from the mistakes and experiences of previous months.
In 2018, I wrote two letters of resignation, grieved the ending of two significant relationships, and spent several weeks on a hospital waiting list for severe depression and weight loss. I fumbled, got lost, and confronted demons that I had been running from my entire life. The result is that I came away with a set of invaluable lessons that I...
Source: World of Psychology - January 4, 2019 Category: Psychiatry & Psychology Authors: Therese J. Borchard Tags: Communication Depression Health-related Industrial and Workplace Inspiration & Hope Marriage and Divorce Mental Health and Wellness Motivation and Inspiration New Year's Perfectionism Personal Psychotherapy Self-Esteem Self-Help Source Type: blogs
Using Big Data to Discover Comorbitities Associated with Psoriasis
Discussion about Big Data; Relevance for Healthcare). A commonly accepted definition for big data is the use of extremely large data sets that may be analyzed computationally to reveal patterns, trends, and associations. I am particularly interested in the use of big data for predictive analytics in healthcare (see: Big data analytics in healthcare: promise and potential). Now comes an article about the use of big data to discover the co-morbidities associated with psoriasis (see:Researchers receive $6.5 million NIH grant to use big data to tackle psoriasis). Below is an excerpt from it:An experienced int...
Source: Lab Soft News - February 27, 2018 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Healthcare Information Technology Healthcare Innovations Medical Research Preventive Medicine Source Type: blogs
Hibernation
I think today and tomorrow I will hibernate. Today is supposed to hit 28 degrees, the first time over 20 degrees in over a week so I might go out for a bit. Overdue library books might motivate me. The cats are going out for a bit. Tomorrow we are due to get a foot of snow. We will both be hibernating with the cats. Friday I will go to the gym and have a friend over for tea.Hibernating is good and bad. The good thing is I don ' t go out and slip on the ice and snow and I won ' t get frostbite. On the down side, it does not help my stress levels. Hibernation can mean isolation. Today I am home alone. Tomorrow, I assume with...
Source: Caroline's Breast Cancer Blog - January 3, 2018 Category: Cancer & Oncology Tags: coping depression isolation winter Source Type: blogs
FDA Approves Sixth United States Biosimilar
Recently, the FDA announced that it approved Boehringer Ingelheim’s Cyltezo (adalimumab-adbm), the second biosimilar to AbbVie’s blockbuster Humira and sixth biosimilar in the United States. “Cyltezo is the first biosimilar from Boehringer Ingelheim to be approved by the FDA and marks an important step towards our goal of providing new and more affordable treatment options to healthcare providers and patients,” said Ivan Blanarik, Senior Vice President and Head of Therapeutic Area Biosimilars at Boehringer Ingelheim. “Chronic inflammatory diseases collectively affect 23.5 million people in the U.S., and Cyltezo h...
Source: Policy and Medicine - November 17, 2017 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs
OPDP Picks Up Steam on Enforcement Letters
After a fairly slow 2016, the United States Food and Drug Administration’s (FDA) Office of Prescription Drug Promotion (OPDP) issued a quick burst of letters in the span of nine days in December. This flurry of activity more than doubled the enforcement letters that had been issued up to that point in the year.
Although there was an apparent increase in enforcement activity in December (perhaps related to the new Administration and the mark the old Administration wanted to leave on the industry), the type of activity and the nature of Draft Guidances issued in 2017 prior to the Trump Administration taking office indicat...
Source: Policy and Medicine - April 5, 2017 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs
3 Ways to Overcome Adversity and Transform It Into Success
Note: This post is written by Zak Khan
Imagine waking up every morning for a month and not being able to function as a normal human being because the joints throughout your body were being attacked by your immune system. Imagine going from a fit 22-year-old law student and writer to an almost bed-ridden fatigued young adult who feels like almost 95 years old.
That’s what happened to me in 2015 and it changed my entire outlook on life. This was the greatest adversity I’ve had to overcome and in doing so, I learned many valuable lessons that I wish to share with you today.
It has been over 18 months since my diagnoses ...
Source: Life Optimizer - March 16, 2017 Category: Consumer Health News Authors: Zak Khan Tags: Attitude Source Type: blogs
It’s time for an honest conversation about pain management
Psoriatic arthritis can be a debilitating condition. It can lead to painful complications such as neuropathy. Its treatments can lead to complications such as shingles, which can leave a patient with continuing pain. Ehlers-Danlos Syndrome is for most patients a painful condition that leads to spontaneous dislocations, early arthritis, and frequent migraines. My husband and I have decades of experience between us in living with these conditions.
My husband and I are also physicians with 57 years experience working with patients between us. We have a world of inside information from both sides of the aisle on the chronic pa...
Source: Kevin, M.D. - Medical Weblog - March 7, 2016 Category: Journals (General) Authors: Holly Clowers, MD Tags: Meds Pain management Source Type: blogs
Wheat Belly is an anti-inflammatory lifestyle
Laura has not only lost a substantial amount of weight from inflammatory visceral fat resulting in a dramatic reduction in waist size, but has also experienced a reduction in the issues associated with her autoimmune diseases:
“I have been on Wheat Belly for about 2 years. I have rheumatoid arthritis and lupus and have seen huge improvements and lowering of meds due to this wonderful plan. So far (and I still need to lose more) I have lost 80 lbs and am still losing. First pic is of me at our high school reunion in 2013 and the next one is today. I think you can see a bit of the difference. I am happy to be down, eve...
Source: Wheat Belly Blog - July 28, 2015 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Success Stories arthritis autoimmune gluten grains lupus rheumatoid Weight Loss Source Type: blogs
