Efficacy and Safety of Risankizumab for Active Psoriatic Arthritis: 100-Week Results from the Phase 3 KEEPsAKE 1 Randomized Clinical Trial
ConclusionsFor patients with active PsA who are csDMARD-IR, risankizumab demonstrated durable long-term efficacy and was generally well tolerated, with a consistent long-term safety profile.Trial RegistrationClinicalTrials.gov identifier, NCT03675308. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - March 18, 2024 Category: Rheumatology Source Type: research
Efficacy and Safety of Risankizumab for Active Psoriatic Arthritis: 100-Week Results from the KEEPsAKE 2 Randomized Clinical Trial
ConclusionsRisankizumab demonstrated durable efficacy and tolerability through 100 weeks; most patients who achieved ACR20 and MDA responses at week 52 maintained this achievement through week 100. There were no new safety signals in patients who had csDMARD-IR and bDMARD-IR.Trial RegistrationClinicalTrials.gov NCT03671148. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - March 18, 2024 Category: Rheumatology Source Type: research
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study
CONCLUSIONS: This study provides valuable insights into the global epidemiology of PsA. It also serves as a useful resource for researchers in areas lacking relevant studies. These findings have important implications for clinicians managing the course of PsA and for health policymakers in resource allocation.PMID:38493674 | DOI:10.1016/j.jaut.2024.103202 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Zijian Kang Xueliang Zhang Yu Du Sheng-Ming Dai Source Type: research
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study
CONCLUSIONS: This study provides valuable insights into the global epidemiology of PsA. It also serves as a useful resource for researchers in areas lacking relevant studies. These findings have important implications for clinicians managing the course of PsA and for health policymakers in resource allocation.PMID:38493674 | DOI:10.1016/j.jaut.2024.103202 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Zijian Kang Xueliang Zhang Yu Du Sheng-Ming Dai Source Type: research
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study
CONCLUSIONS: This study provides valuable insights into the global epidemiology of PsA. It also serves as a useful resource for researchers in areas lacking relevant studies. These findings have important implications for clinicians managing the course of PsA and for health policymakers in resource allocation.PMID:38493674 | DOI:10.1016/j.jaut.2024.103202 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Zijian Kang Xueliang Zhang Yu Du Sheng-Ming Dai Source Type: research
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study
CONCLUSIONS: This study provides valuable insights into the global epidemiology of PsA. It also serves as a useful resource for researchers in areas lacking relevant studies. These findings have important implications for clinicians managing the course of PsA and for health policymakers in resource allocation.PMID:38493674 | DOI:10.1016/j.jaut.2024.103202 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Zijian Kang Xueliang Zhang Yu Du Sheng-Ming Dai Source Type: research
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study
CONCLUSIONS: This study provides valuable insights into the global epidemiology of PsA. It also serves as a useful resource for researchers in areas lacking relevant studies. These findings have important implications for clinicians managing the course of PsA and for health policymakers in resource allocation.PMID:38493674 | DOI:10.1016/j.jaut.2024.103202 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - March 17, 2024 Category: Allergy & Immunology Authors: Zijian Kang Xueliang Zhang Yu Du Sheng-Ming Dai Source Type: research
Genes, Vol. 15, Pages 369: PDE4 Gene Family Variants Are Associated with Response to Apremilast Treatment in Psoriasis
This study implements a candidate-gene and a network-based approach to identify genetic markers associated with apremilast response in forty-nine Greek Ps patients. Our data revealed an association of sixty-four SNPs within or near PDE4 and CYP3A4 genes, four SNPs in ncRNAs ANRIL, LINC00941 and miR4706, which influence the abundance or function of PDE4s, and thirty-three SNPs within fourteen genes whose protein products either interact directly with PDE4 proteins or constitute components of the cAMP signaling pathway which is modulated by PDE4s. Notably, fifty-six of the aforementioned SNPs constitute eQTLs for the respect...
Source: Genes - March 17, 2024 Category: Genetics & Stem Cells Authors: Kalliopi Liadaki Efterpi Zafiriou Themistoklis Giannoulis Sofia Alexouda Kleoniki Chaidaki Polyxeni Gidarokosta Angeliki-Viktoria Roussaki-Schulze Sotirios G. Tsiogkas Athina Daponte Zissis Mamuris Dimitrios P. Bogdanos Nicholas K. Moschonas Theologia Sar Tags: Article Source Type: research
Executive Summary: From the Medical Board of the National Psoriasis Foundation: Perioperative management of immunomodulatory agents in patients with psoriasis and psoriatic arthritis
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 16, 2024 Category: Dermatology Authors: Warren A. James, Angela L. Rosenberg, Jashin J. Wu, Sylvia Hsu, April Armstrong, Elizabeth B. Wallace, Lara Wine Lee, Joseph Merola, Sergio Schwartzman, Dafna Gladman, Clive Liu, John Koo, Jason E. Hawkes, Soumya Reddy, Ron Prussick, Paul Yamauchi, Michae Source Type: research
Defining the minimal important change and meaningful change value of the disease activity index for psoriatic arthritis: a Chinese longitudinal study
CONCLUSION: MIC, offering physicians an additional means to contextualize the patient's perception of disease activity during treatment, and a change of 10.5 is likely to be regarded as a clinically meaningful change, enhancing the utility of DAPSA in PsA clinical trials.PMID:38490673 | DOI:10.3899/jrheum.2023-1085 (Source: J Rheumatol)
Source: J Rheumatol - March 15, 2024 Category: Rheumatology Authors: Yijie Liu Minjia Tan Kun Hu SiChun Deng Lu Jian Junchen Chen Mi Zhang Yehong Kuang Source Type: research
Defining the minimal important change and meaningful change value of the disease activity index for psoriatic arthritis: a Chinese longitudinal study
CONCLUSION: MIC, offering physicians an additional means to contextualize the patient's perception of disease activity during treatment, and a change of 10.5 is likely to be regarded as a clinically meaningful change, enhancing the utility of DAPSA in PsA clinical trials.PMID:38490673 | DOI:10.3899/jrheum.2023-1085 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 15, 2024 Category: Rheumatology Authors: Yijie Liu Minjia Tan Kun Hu SiChun Deng Lu Jian Junchen Chen Mi Zhang Yehong Kuang Source Type: research
Defining the minimal important change and meaningful change value of the disease activity index for psoriatic arthritis: a Chinese longitudinal study
CONCLUSION: MIC, offering physicians an additional means to contextualize the patient's perception of disease activity during treatment, and a change of 10.5 is likely to be regarded as a clinically meaningful change, enhancing the utility of DAPSA in PsA clinical trials.PMID:38490673 | DOI:10.3899/jrheum.2023-1085 (Source: J Rheumatol)
Source: J Rheumatol - March 15, 2024 Category: Rheumatology Authors: Yijie Liu Minjia Tan Kun Hu SiChun Deng Lu Jian Junchen Chen Mi Zhang Yehong Kuang Source Type: research
Defining the minimal important change and meaningful change value of the disease activity index for psoriatic arthritis: a Chinese longitudinal study
CONCLUSION: MIC, offering physicians an additional means to contextualize the patient's perception of disease activity during treatment, and a change of 10.5 is likely to be regarded as a clinically meaningful change, enhancing the utility of DAPSA in PsA clinical trials.PMID:38490673 | DOI:10.3899/jrheum.2023-1085 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - March 15, 2024 Category: Rheumatology Authors: Yijie Liu Minjia Tan Kun Hu SiChun Deng Lu Jian Junchen Chen Mi Zhang Yehong Kuang Source Type: research
Defining the minimal important change and meaningful change value of the disease activity index for psoriatic arthritis: a Chinese longitudinal study
CONCLUSION: MIC, offering physicians an additional means to contextualize the patient's perception of disease activity during treatment, and a change of 10.5 is likely to be regarded as a clinically meaningful change, enhancing the utility of DAPSA in PsA clinical trials.PMID:38490673 | DOI:10.3899/jrheum.2023-1085 (Source: J Rheumatol)
Source: J Rheumatol - March 15, 2024 Category: Rheumatology Authors: Yijie Liu Minjia Tan Kun Hu SiChun Deng Lu Jian Junchen Chen Mi Zhang Yehong Kuang Source Type: research
