Genes, Vol. 15, Pages 369: PDE4 Gene Family Variants Are Associated with Response to Apremilast Treatment in Psoriasis

This study implements a candidate-gene and a network-based approach to identify genetic markers associated with apremilast response in forty-nine Greek Ps patients. Our data revealed an association of sixty-four SNPs within or near PDE4 and CYP3A4 genes, four SNPs in ncRNAs ANRIL, LINC00941 and miR4706, which influence the abundance or function of PDE4s, and thirty-three SNPs within fourteen genes whose protein products either interact directly with PDE4 proteins or constitute components of the cAMP signaling pathway which is modulated by PDE4s. Notably, fifty-six of the aforementioned SNPs constitute eQTLs for the respective genes in relevant to psoriasis tissues/cells implying that these variants could be causal. Our analysis provides a number of novel genetic variants that, upon validation in larger cohorts, could be utilized as predictive markers regarding the response of Ps patients to apremilast treatment.

Source: Genes - March 17, 2024 Category: Genetics & Stem Cells Authors: Kalliopi Liadaki Efterpi Zafiriou Themistoklis Giannoulis Sofia Alexouda Kleoniki Chaidaki Polyxeni Gidarokosta Angeliki-Viktoria Roussaki-Schulze Sotirios G. Tsiogkas Athina Daponte Zissis Mamuris Dimitrios P. Bogdanos Nicholas K. Moschonas Theologia Sar Tags: Article Source Type: research