Relationships of Proton Pump Inhibitor-Induced Renal Injury with CYP2C19 Polymorphism: A Retrospective Cohort Study
In conclusion, this retrospective study showed that CYP2C19 metabolizer status was associated with the time to a 30% eGFR decrease in patients treated with lansoprazole, but not with esomeprazole, rabeprazole, or vonoprazan.PMID:38258325 | DOI:10.1002/cpt.3183 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - January 23, 2024 Category: Drugs & Pharmacology Authors: Rika Fukui Satoshi Noda Yoshito Ikeda Yuichi Sawayama Tomohiro Terada Yoshihisa Nakagawa Shin-Ya Morita Source Type: research
In vitro interactions of proton pump inhibitors and azoles against pathogenic fungi
DiscussionThe results suggested that PPIs combined with azoles has the potential to enhance the susceptibilities of azoles against multiple pathogenic fungi and could be a promising strategy to overcome azole resistance issues. However, further investigations are warranted to study the combinational efficacy in more isolates and more species, to investigate the underlying mechanism of interaction and to evaluate the potential for concomitant use of these agents in human. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - January 17, 2024 Category: Microbiology Source Type: research
Trend analysis of proton pump inhibitor consumption and expenditure: The real-world evidence
ConclusionWithin this analysis, we provide an illustrative representation of the prescribing trends for PPIs within a European context. Omeprazole, rabeprazole and lansoprazole appear to be the cheapest drugs compared to pantoprazole and esomeprazole. However, the results show that the most widely used PPIs, despite their therapeutic equivalence, are precisely the high-cost ones, thus generating higher expenditure for central governments.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - January 17, 2024 Category: Gastroenterology Source Type: research
Comparative efficiency and safety of potassium competitive acid blockers versus Lansoprazole in peptic ulcer: a systematic review and meta-analysis
Conclusion: P-CABs demonstrated non-inferiority to lansoprazole in the management of peptic ulcer. The safety and tolerability profile are comparable, with similar TEAEs rates. However, P-CABs appear to have a higher risk of serious adverse events.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=458361 Identifier: PROSPERO (No. CRD42023458361). (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 11, 2024 Category: Drugs & Pharmacology Source Type: research
Prescribing Patterns of Proton Pump Inhibitors in Germany: A Retrospective Study Including 472 146 Patients
This study highlights that discrepancies exist between clinical guidelines and real-life prescribing practices of PPIs in Germany. Particular attention should be given to the incidence of patients being prescribed high-dose or long-duration PPI with mild indications. These findings are particularly apt considering the publication (March 2023) of new guidelines on the "management of gastroesophageal reflux disease and eosinophilic esophagitis," by the DGVS.PMID:38142444 | DOI:10.1177/21501319231221002 (Source: Primary Care)
Source: Primary Care - December 24, 2023 Category: Primary Care Authors: Kate Plehhova Monika Haering Joshua Wray Cathal Coyle Eduardo Ib áñez Karel Kostev Source Type: research
Prescribing Patterns of Proton Pump Inhibitors in Germany: A Retrospective Study Including 472 146 Patients
This study highlights that discrepancies exist between clinical guidelines and real-life prescribing practices of PPIs in Germany. Particular attention should be given to the incidence of patients being prescribed high-dose or long-duration PPI with mild indications. These findings are particularly apt considering the publication (March 2023) of new guidelines on the "management of gastroesophageal reflux disease and eosinophilic esophagitis," by the DGVS.PMID:38142444 | PMC:PMC10749518 | DOI:10.1177/21501319231221002 (Source: Primary Care)
Source: Primary Care - December 24, 2023 Category: Primary Care Authors: Kate Plehhova Monika Haering Joshua Wray Cathal Coyle Eduardo Ib áñez Karel Kostev Source Type: research
Anti-inflammatory effects of Weiyan I decoction against gastric ulcers in a rat model via inhibition of p38 mitogen-activated protein kinases signaling
This study aimed to explore the therapeutic mechanism of WYI in GU. WYI constituents were analyzed via ultra-high-performance liquid chromatography-mass spectrometry. SD rats were divided into control, model, lansoprazole (30mg/kg), SB203580 (2mg/kg), WYI (10.8g/kg, 5.4g/kg and 2.7g/kg) groups. GU was induced using ethanol or indomethacin post-WYI pre-administration. Ulcer area, histopathology, serum prostaglandin E2 (PGE2), nitric oxide (NO), gastric tissue cytokines and mitogen-activated protein kinases (MAPKs) were evaluated. Gastric mucus content and pH were determined in the pylorus ligation rat model. Administration ...
Source: Cancer Control - December 21, 2023 Category: Cancer & Oncology Authors: Xu Yifei Hong Xinxin Luo Liuru Lin Yandan Li Jingwei Li Haiwen Guo Shaoju Huang Bin Source Type: research
Acid ‐suppressive drugs: A systematic review and network meta‐analysis of their nocturnal acid‐inhibitory effect
ConclusionsThis is the first study to compare the effect of ASDs on inhibiting nocturnal acid breakthrough. Overall, in terms of nocturnal acid-inhibitory effect, vonoprazan and tegoprazan had an advantage against other regimens including H2RAs, isomer PPIs, traditional PPIs, AHB, and new PPIs. Even in some subgroups, such as language classification (English), types of study design (crossover-RCT), age ( ≤40 years), BMI (18.5-24.9 kg/m2), continent (Asia and North America), disease status (health), the duration of therapy (2 weeks), and time of administration (at daytime or at night-time), the nocturnal acid-inhibit...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 5, 2023 Category: Drugs & Pharmacology Authors: Shupeng Zou,
Mengling Ouyang,
Qian Cheng,
Xuan Shi,
Minghui Sun Tags: RESEARCH ARTICLE Source Type: research
Lansoprazole inhibits the development of sessile serrated lesions by inducing G1 arrest via Skp2/p27 signaling pathway
ConclusionsOur data strongly suggest that lansoprazole is the most effective chemopreventive agent against SSL, and that lansoprazole induces G1 cell cycle arrest by downregulating Skp2 and upregulating p27 in SSL cells. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - November 22, 2023 Category: Gastroenterology Source Type: research
Enzymatic synthesis of pharmacologically relevant chiral sulfoxides by improved < em > Cb < /em > BVMO variants
Chem Commun (Camb). 2023 Nov 21. doi: 10.1039/d3cc05463b. Online ahead of print.ABSTRACTBaeyer-Villiger monooxygenases (BVMOs) are able to catalyse the asymmetric oxidation of sulfides. This property has made them attractive catalysts for the synthesis of chiral sulfoxide drugs. Here, we have designed and synthesised an exhaustive combinatorial mutant library of the previously identified lansoprazole sulfide monooxygenase CbBVMOV1. From this synthetic combinatorial mutant library, the best mutant, CbBVMOV3, was selected with a specific activity of approximately 1 U mg-1 for lansoprazole sulfoxides. We then optimised the re...
Source: Chemical Communications - November 21, 2023 Category: Chemistry Authors: Chen Zhao Feng Liu Min Zhou Qiang Geng Hui-Lei Yu Source Type: research
Clinical pharmacokinetics of nebivolol: a systematic review
Drug Metab Rev. 2023 Oct 17:1-13. doi: 10.1080/03602532.2023.2271195. Online ahead of print.ABSTRACTNebivolol is a beta-1 receptor blocker used to treat hypertension, heart failure, erectile dysfunction, vascular disease, and diabetes mellitus. This review investigated the data regarding pharmacokinetic (PK) parameters, drug-drug interactions, dextrorotatory (D), and levorotatory (L) stereoisomers of nebivolol. The articles related to the PK of nebivolol were retrieved by searching the five databases; Google Scholar, PubMed, Cochrane Library, ScienceDirect, and EBSCO. A total of 20 studies comprising plasma concentration-t...
Source: Drug Metabolism Reviews - October 18, 2023 Category: Drugs & Pharmacology Authors: Nida Hanif Ammara Zamir Imran Imran Hamid Saeed Abdul Majeed Anees Ur Rehman Waseem Ashraf Faleh Alqahtani Muhammad Fawad Rasool Source Type: research
