80-Year-Old Man With Vision Loss
An 80-year-old man presented to the emergency department with a 1-week history of progressive, transient, monocular vision loss, binocular diplopia, transient headache, and lightheadedness. Clinical comorbidities included obesity, hypertension, hyperlipidemia, former tobacco smoking, and femoral popliteal artery bypass surgery. He also had bilateral cataract surgery the month before presentation, which occurred without complications. Upon presentation, the patient ’s medications included aspirin 325 mg daily (prescribed after bypass surgery), hydrochlorothiazide 25 mg daily, lansoprazole 15 mg daily, losartan 25 mg twice...
Source: Mayo Clinic Proceedings - June 6, 2023 Category: Internal Medicine Authors: Audrey M. Blazek, Robert J. Haemmerle, James F. Meschia Tags: Residents ’ Clinic Source Type: research
Synergistic Effect of Metformin and Lansoprazole Against Gastric Cancer through Growth Inhibition
Int J Med Sci. 2023 Apr 17;20(6):717-724. doi: 10.7150/ijms.82407. eCollection 2023.ABSTRACTCancer has been linked to metabolic disorders and diverse gene mutations. Metformin, which is widely used to treat type 2 diabetes, inhibits the growth of cancer cells in animal models. Here we investigated the effects of metformin on human gastric cancer cell lines. We also investigated the synergistic anticancer effect of metformin and proton pump inhibitors. Lansoprazole, a proton pump inhibitor, is effective for treating gastroesophageal reflux disease. Our results revealed that metformin and lansoprazole can significantly inhib...
Source: International Journal of Medical Sciences - May 22, 2023 Category: Biomedical Science Authors: Hsiao-Wei Kao Kuo-Wang Tsai Wen-Chang Lin Source Type: research
