Time-Varying Use of Proton Pump Inhibitors and Cognitive Impairment and Dementia: A Real-World Analysis from Germany
ConclusionOur large study supports existing evidence that PPI use is related to an increased risk of dementia. (Source: Drugs and Aging)
Source: Drugs and Aging - May 13, 2023 Category: Geriatrics Source Type: research
Pharmacokinetics and Pharmacodynamics of Lansoprazole/Sodium Bicarbonate Immediate ‐release Capsules in Healthy Chinese Subjects: An Open, Randomized, Controlled, Crossover, Single‐, and Multiple‐dose Trial
AbstractProton pump inhibitors (PPIs) differ in onset of action and bioavailability. This trial was conducted to investigate the pharmacokinetics and pharmacodynamics of an immediate-release capsule formulation containing lansoprazole 30 mg and sodium bicarbonate 1100 mg (T preparation) in healthy Chinese subjects. This was an open, single-center, randomized, single and multiple oral doses, and two-period crossover study in 30 healthy subjects. After single- and multiple-dose oral administration, blood samples were obtained and l ansoprazole concentration in serum was measured for pharmacokinetic analysis. Meanwhile, th...
Source: Clinical Pharmacology in Drug Development - May 11, 2023 Category: Drugs & Pharmacology Authors: Lixiu Yu,
Xuejia Zhai,
Sanlan Wu,
Peng Cao,
Yahui Deng,
Quancheng Yang,
Qilin Zhang,
Jiancai Wu,
Yue Deng,
Qiaoling Liu,
Yu Zhang Tags: Original Article Source Type: research
Association between clinical use of lansoprazole and the risk of type 2 diabetes mellitus: a pharmacoepidemiological cohort study
Proton pump inhibitors (PPIs) are common and widely used for gastrointestinal-related disorders. Lansoprazole is one of PPIs with potential benefits of anti-inflammation, reduced oxidative stress, and anti-dia... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - May 10, 2023 Category: Endocrinology Authors: Ming-Hsun Lin, Wen ‐Tung Wu, Yong-Chen Chen, Tsung-Kun Lin, Yu‐Ching Chou and Chien‐An Sun Tags: Research Source Type: research
The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment
CONCLUSION: Endoplasmic reticulum stress can be for evaluating the clinical improvement and the effectiveness of treatment in gastroesophageal reflux disease.PMID:37158535 | DOI:10.5152/tjg.2023.21282 (Source: The Turkish Journal of Gastroenterology)
Source: The Turkish Journal of Gastroenterology - May 9, 2023 Category: Gastroenterology Authors: Elmas Kasap Tahir Buran Aysun Toraman Avcu P ınar Solmaz Hasdemir Erdal Balcan Çağdaş Aktan Mehmet Korkmaz Source Type: research
Rare Case of Benign Transient Hyperphosphatasemia in a Complicated Multiorgan Adult Transplant Patient: Case Report and Literature Review
Conclusions After ruling out all possibilities that may cause elevated ALP, we concluded that this is a rare case of benign transient hyperphosphatasemia in an adult transplant recipient.PMID:37105451 | DOI:10.1016/j.cca.2023.117364 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 27, 2023 Category: Chemistry Authors: Robert Hoyt Fredrick V Plapp Zhan Ye Amitava Dasgupta Source Type: research
Rare Case of Benign Transient Hyperphosphatasemia in a Complicated Multiorgan Adult Transplant Patient: Case Report and Literature Review
Conclusions After ruling out all possibilities that may cause elevated ALP, we concluded that this is a rare case of benign transient hyperphosphatasemia in an adult transplant recipient.PMID:37105451 | DOI:10.1016/j.cca.2023.117364 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 27, 2023 Category: Cancer & Oncology Authors: Robert Hoyt Fredrick V Plapp Zhan Ye Amitava Dasgupta Source Type: research
Rare Case of Benign Transient Hyperphosphatasemia in a Complicated Multiorgan Adult Transplant Patient: Case Report and Literature Review
Conclusions After ruling out all possibilities that may cause elevated ALP, we concluded that this is a rare case of benign transient hyperphosphatasemia in an adult transplant recipient.PMID:37105451 | DOI:10.1016/j.cca.2023.117364 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 27, 2023 Category: Chemistry Authors: Robert Hoyt Fredrick V Plapp Zhan Ye Amitava Dasgupta Source Type: research
Efficacy and Safety of Vonoprazan and Amoxicillin Dual Therapy for < i > Helicobacter pylori < /i > Eradication: A Systematic Review and Meta-Analysis
Conclusions: The efficacy of vonoprazan/amoxicillin dual therapy is noninferior to vonoprazan-based triple therapy but superior to the omeprazole or lansoprazole-based triple therapy and has less side effects. Patients with clarithromycin-resistant strains are particularly expected to benefit from vonoprazan/amoxicillin dual therapy.Digestion (Source: Digestion)
Source: Digestion - April 4, 2023 Category: Gastroenterology Source Type: research
A Case of Duodenal Diverticular Perforation Treated Conservatively: Reassessing Indications for Treatment
Intern Med. 2023 Mar 22. doi: 10.2169/internalmedicine.1211-22. Online ahead of print.ABSTRACTA 59-year-old woman presented with a chief complaint of melena. She had no abdominal findings, such as tenderness or tapping pain. Laboratory tests revealed a white blood cell count of 5,300 cells/μL and C-reactive protein level of 0.07 mg/dL. Inflammation and anemia (hemoglobin 12.4 g/dL) were denied. Contrast-enhanced computed tomography (CT) revealed multiple duodenal diverticula and air surrounding a descending duodenal diverticulum. Based on these findings, duodenal diverticular perforation (DDP) was suspected. Oral food int...
Source: Internal Medicine - March 22, 2023 Category: Internal Medicine Authors: Yuri Sasaki Jun Nakahodo Tomoko Onishi Ayu Tachibana Ryogo Minami Eriko Noma Yoshiaki Moriguchi Hiroki Tabata Ryoko Shimizuguchi Akinari Takao Satomi Shibata Kazuro Chiba Takeo Arakawa Toshiro Iizuka Terumi Kamisawa Source Type: research
