Attuning doped ZnO-based composites for an effective light-driven mineralization of pharmaceuticals via PMS activation
In this study, we investigated the effect of doping ZnO nanoparticles with either copper, gallium or indium on the structure, morphology, photophysical properties and photocatalytic mineralization of pharmaceuticals. Their architecture was further improved through the fabrication of composites, pairing the best performing doped ZnO with either BaFe12O19 or nickel nanoparticles. Their suitability was tested on a complex 60-ppm multi-pollutant solution (tetracycline, levofloxacin and lansoprazole). The activation strategy combined photocatalysis with peroxymonosulfate (PMS) as an environmentally friendly source of highly oxi...
Source: Chemosphere - April 25, 2024 Category: Chemistry Authors: Roger Bujald ón Majdi Benamara Ramzi Dhahri Elvira G ómez Albert Serr à Source Type: research
Vonoprazan 10 mg or 20 mg vs. lansoprazole 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis: A randomized controlled trial
CONCLUSION: Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence in Asian patients with healed EE.TRIAL REGISTRATION: https://clinicaltrials.gov; NCT02388737.PMID:38654422 | DOI:10.1097/CM9.0000000000003068 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 24, 2024 Category: General Medicine Authors: Yinglian Xiao Jiaming Qian Shutian Zhang Ning Dai Hoon Jai Chun Chengtang Chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai Jessica D Eisner Li Xie Minhu Chen Source Type: research
Proton Pump Inhibitors and Cancer Risk: A Comprehensive Review of Epidemiological and Mechanistic Evidence
Conclusions: Despite the well-established cancer risk associated with PPIs, it is notable that these medications continue to be widely prescribed for periods longer than 3 months. Thus, it is of paramount importance for clinicians and patients to thoughtfully evaluate the potential risks and benefits of long-term PPI usage and explore alternative treatments before making informed decisions regarding their medical management.PMID:38610738 | DOI:10.3390/jcm13071970 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Ibrahim O Sawaid Abraham O Samson Source Type: research
Proton Pump Inhibitors and Cancer Risk: A Comprehensive Review of Epidemiological and Mechanistic Evidence
Conclusions: Despite the well-established cancer risk associated with PPIs, it is notable that these medications continue to be widely prescribed for periods longer than 3 months. Thus, it is of paramount importance for clinicians and patients to thoughtfully evaluate the potential risks and benefits of long-term PPI usage and explore alternative treatments before making informed decisions regarding their medical management.PMID:38610738 | PMC:PMC11012754 | DOI:10.3390/jcm13071970 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Ibrahim O Sawaid Abraham O Samson Source Type: research
DNA adductomics aided rapid screening of genotoxic impurities using nucleosides and 3D bioprinted human liver organoids
In this study, a new approach for the recognition of GTIs has been proposed. It is to expose the complex samples to an in vitro nucleoside incubation model, and then draw complete DNA adduct profiles to infer the structures of potential genotoxic impurities (PGIs). Subsequently, the genotoxicity is confirmed in human by 3D bioprinted human liver organoids. To verify the feasibility of the approach, lansoprazole chloride compound (Lanchlor), a PGI during the synthesis of lansoprazole, was selected as the model drug. After confirming genotoxicity by Comet assay, it was exposed to different models to map and compare the DNA a...
Source: Talanta - March 20, 2024 Category: Chemistry Authors: Ying Li Chen Xu Xueting Zhou Jinhong Li Shiting Xu Yuanbo Tu Xue Mu Jiajun Huang Qing Huang Lifeng Kang Huaisong Wang Mei Zhang Yaozuo Yuan Chunyong Wu Junying Zhang Source Type: research
DNA adductomics aided rapid screening of genotoxic impurities using nucleosides and 3D bioprinted human liver organoids
In this study, a new approach for the recognition of GTIs has been proposed. It is to expose the complex samples to an in vitro nucleoside incubation model, and then draw complete DNA adduct profiles to infer the structures of potential genotoxic impurities (PGIs). Subsequently, the genotoxicity is confirmed in human by 3D bioprinted human liver organoids. To verify the feasibility of the approach, lansoprazole chloride compound (Lanchlor), a PGI during the synthesis of lansoprazole, was selected as the model drug. After confirming genotoxicity by Comet assay, it was exposed to different models to map and compare the DNA a...
Source: Talanta - March 20, 2024 Category: Chemistry Authors: Ying Li Chen Xu Xueting Zhou Jinhong Li Shiting Xu Yuanbo Tu Xue Mu Jiajun Huang Qing Huang Lifeng Kang Huaisong Wang Mei Zhang Yaozuo Yuan Chunyong Wu Junying Zhang Source Type: research
A Case of Idiopathic Peptic Ulcer Disease Treated Effectively with Trimebutine Maleat
Acta Med Okayama. 2024 Feb;78(1):85-88. doi: 10.18926/AMO/66675.ABSTRACTA 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential eff...
Source: Acta Med Okayama - February 29, 2024 Category: Universities & Medical Training Authors: Keisuke Miyake Tomohiro Tanikawa Ken Haruma Mayuko Kawada Katsunori Ishii Noriyo Urata Ken Nishino Mitsuhiko Suehiro Miwa Kawanaka Noriaki Manabe Hirofumi Kawamoto Source Type: research
A Case of Idiopathic Peptic Ulcer Disease Treated Effectively with Trimebutine Maleat
Acta Med Okayama. 2024 Feb;78(1):85-88. doi: 10.18926/AMO/66675.ABSTRACTA 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential eff...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Keisuke Miyake Tomohiro Tanikawa Ken Haruma Mayuko Kawada Katsunori Ishii Noriyo Urata Ken Nishino Mitsuhiko Suehiro Miwa Kawanaka Noriaki Manabe Hirofumi Kawamoto Source Type: research
A Case of Idiopathic Peptic Ulcer Disease Treated Effectively with Trimebutine Maleat
Acta Med Okayama. 2024 Feb;78(1):85-88. doi: 10.18926/AMO/66675.ABSTRACTA 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential eff...
Source: Acta Med Okayama - February 29, 2024 Category: Universities & Medical Training Authors: Keisuke Miyake Tomohiro Tanikawa Ken Haruma Mayuko Kawada Katsunori Ishii Noriyo Urata Ken Nishino Mitsuhiko Suehiro Miwa Kawanaka Noriaki Manabe Hirofumi Kawamoto Source Type: research
A Case of Idiopathic Peptic Ulcer Disease Treated Effectively with Trimebutine Maleat
Acta Med Okayama. 2024 Feb;78(1):85-88. doi: 10.18926/AMO/66675.ABSTRACTA 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential eff...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Keisuke Miyake Tomohiro Tanikawa Ken Haruma Mayuko Kawada Katsunori Ishii Noriyo Urata Ken Nishino Mitsuhiko Suehiro Miwa Kawanaka Noriaki Manabe Hirofumi Kawamoto Source Type: research
A Case of Idiopathic Peptic Ulcer Disease Treated Effectively with Trimebutine Maleat
Acta Med Okayama. 2024 Feb;78(1):85-88. doi: 10.18926/AMO/66675.ABSTRACTA 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential eff...
Source: Acta Med Okayama - February 29, 2024 Category: Universities & Medical Training Authors: Keisuke Miyake Tomohiro Tanikawa Ken Haruma Mayuko Kawada Katsunori Ishii Noriyo Urata Ken Nishino Mitsuhiko Suehiro Miwa Kawanaka Noriaki Manabe Hirofumi Kawamoto Source Type: research
A Case of Idiopathic Peptic Ulcer Disease Treated Effectively with Trimebutine Maleat
Acta Med Okayama. 2024 Feb;78(1):85-88. doi: 10.18926/AMO/66675.ABSTRACTA 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential eff...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Keisuke Miyake Tomohiro Tanikawa Ken Haruma Mayuko Kawada Katsunori Ishii Noriyo Urata Ken Nishino Mitsuhiko Suehiro Miwa Kawanaka Noriaki Manabe Hirofumi Kawamoto Source Type: research
A Case of Idiopathic Peptic Ulcer Disease Treated Effectively with Trimebutine Maleat
Acta Med Okayama. 2024 Feb;78(1):85-88. doi: 10.18926/AMO/66675.ABSTRACTA 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential eff...
Source: Acta Med Okayama - February 29, 2024 Category: Universities & Medical Training Authors: Keisuke Miyake Tomohiro Tanikawa Ken Haruma Mayuko Kawada Katsunori Ishii Noriyo Urata Ken Nishino Mitsuhiko Suehiro Miwa Kawanaka Noriaki Manabe Hirofumi Kawamoto Source Type: research
A Case of Idiopathic Peptic Ulcer Disease Treated Effectively with Trimebutine Maleat
Acta Med Okayama. 2024 Feb;78(1):85-88. doi: 10.18926/AMO/66675.ABSTRACTA 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential eff...
Source: Acta Medica Okayama - February 29, 2024 Category: General Medicine Authors: Keisuke Miyake Tomohiro Tanikawa Ken Haruma Mayuko Kawada Katsunori Ishii Noriyo Urata Ken Nishino Mitsuhiko Suehiro Miwa Kawanaka Noriaki Manabe Hirofumi Kawamoto Source Type: research
A Case of Idiopathic Peptic Ulcer Disease Treated Effectively with Trimebutine Maleat
Acta Med Okayama. 2024 Feb;78(1):85-88. doi: 10.18926/AMO/66675.ABSTRACTA 30-year-old man with idiopathic peptic ulcer disease (IPUD) experienced repeated recurrence of ulcerative bleeding despite treatment with lansoprazole and then vonoprazan. Further evaluation suggested that the cause of the ulcer was strong contractile movements of the antrum. This prompted the co-administration of trimebutine maleate (TM) and vonoprazan to relieve the stomach contractions. TM was effective in preventing the recurrence of ulcerative bleeding, and the patient has remained in remission for 4 years. This case highlights the potential eff...
Source: Acta Med Okayama - February 29, 2024 Category: Universities & Medical Training Authors: Keisuke Miyake Tomohiro Tanikawa Ken Haruma Mayuko Kawada Katsunori Ishii Noriyo Urata Ken Nishino Mitsuhiko Suehiro Miwa Kawanaka Noriaki Manabe Hirofumi Kawamoto Source Type: research
