Cutaneous adverse reactions associated with COVID-19 vaccines: Current evidence and potential immune mechanisms
Clin Immunol. 2024 Apr 18:110220. doi: 10.1016/j.clim.2024.110220. Online ahead of print.ABSTRACTAs the number of vaccinated individuals has increased, there have been increasing reports of cutaneous hypersensitivity reactions. The main COVID-19 vaccines administered include messenger ribonucleic acid vaccines, non-replicating viral vector vaccines, inactivated whole-virus vaccines, and protein-based vaccines. These vaccines contain active components such as polyethylene glycol, polysorbate 80, aluminum, tromethamine, and disodium edetate dihydrate. Recent advances in understanding the coordination of inflammatory response...
Source: Clinical Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Po-Chien Wu Wan-Chen Lin Chuang-Wei Wang Wen-Hung Chung Chun-Bing Chen Source Type: research
Unusually large microporous HKUST-1 via polyethylene glycol-templated synthesis: enhanced CO < sub > 2 < /sub > uptake with high selectivity over CH < sub > 4 < /sub > and N < sub > 2 < /sub >
Environ Sci Pollut Res Int. 2024 Apr 17. doi: 10.1007/s11356-024-33263-4. Online ahead of print.ABSTRACTPorous solids with highly microporous structures for effective carbon dioxide uptake and separation from mixed gases are highly desirable. Here we present the use of polyethylene glycol (20,000 g/mol) as a soft template for the simple and rapid synthesis of a highly microporous Cu-BTC (denoted as HKUST-1). The polyethylene glycol-templated HKUST-1 obtained at room temperature in 10 min exhibited a very high Brunauer-Emmett-Teller (BET) surface area of 1904 m2/g, pore volume of 0.87 cm3/g, and average micropore size of 0....
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Fahed A Aloufi Nadhem Missaoui Riyadh F Halawani Hamza Kahri Bassem Jamoussi Andrew J Gross Source Type: research
Unusually large microporous HKUST-1 via polyethylene glycol-templated synthesis: enhanced CO < sub > 2 < /sub > uptake with high selectivity over CH < sub > 4 < /sub > and N < sub > 2 < /sub >
Environ Sci Pollut Res Int. 2024 Apr 17. doi: 10.1007/s11356-024-33263-4. Online ahead of print.ABSTRACTPorous solids with highly microporous structures for effective carbon dioxide uptake and separation from mixed gases are highly desirable. Here we present the use of polyethylene glycol (20,000 g/mol) as a soft template for the simple and rapid synthesis of a highly microporous Cu-BTC (denoted as HKUST-1). The polyethylene glycol-templated HKUST-1 obtained at room temperature in 10 min exhibited a very high Brunauer-Emmett-Teller (BET) surface area of 1904 m2/g, pore volume of 0.87 cm3/g, and average micropore size of 0....
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Fahed A Aloufi Nadhem Missaoui Riyadh F Halawani Hamza Kahri Bassem Jamoussi Andrew J Gross Source Type: research
Metagenomic investigations into the microbial consortia, degradation pathways, and enzyme systems involved in the biodegradation of plastics in a tropical lentic pond sediment
AbstractThe exploitation of exciting features of plastics for diverse applications has resulted in significant plastic waste generation, which negatively impacts environmental compartments, metabolic processes, and the well-being of aquatic ecosystems biota. A shotgun metagenomic approach was deployed to investigate the microbial consortia, degradation pathways, and enzyme systems involved in the degradation of plastics in a tropical lentic pond sediment (APS). Functional annotation of the APS proteome (ORFs) using the PlasticDB database revealed annotation of 1015 proteins of enzymes such as depolymerase, esterase, lipase...
Source: World Journal of Microbiology and Biotechnology - April 17, 2024 Category: Microbiology Source Type: research
Polyvinyl alcohol/chitosan quaternary ammonium salt composite hydrogel with directional macroporous structure for photothermal synergistic antibacterial and wound healing promotion
Int J Biol Macromol. 2024 Apr 14:131549. doi: 10.1016/j.ijbiomac.2024.131549. Online ahead of print.ABSTRACTAfter skin tissue trauma, wound infections caused by bacteria posed a great threat to skin repair. However, resistance to antibiotics, the current treatment of choice for bacterial infections, greatly affected the efficiency of anti-infection and wound healing. Therefore, there has been a critical need for the development of novel antimicrobial materials and advanced therapeutic methods to aid in skin repair. In this paper, rGO-PDA@ZIF-8 nanofillers were prepared by coating graphene oxide (GO) with dopamine (DA), fol...
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Xianyu Lan Hang Yang Yuzhu Xiong Guanyue Zeng Fuping Dong Source Type: research
Design, optimization and pharmaceutical characterization of wound healing film dressings with chloramphenicol and ibuprofen
CONCLUSIONS: The QbD approach was successfully implemented to develop and optimize a novel film dressing promising for the treatment of low-exuding acute wounds prone to infection and inflammation.PMID:38622817 | DOI:10.1080/03639045.2024.2339306 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 16, 2024 Category: Drugs & Pharmacology Authors: Ioana Savencu Sonia Iurian C ătălina Bogdan Nicoleta Sp înu Maria Suciu Anca Pop Alexandru Țoc Ioan Tomu ță Source Type: research
Polyvinyl alcohol/chitosan quaternary ammonium salt composite hydrogel with directional macroporous structure for photothermal synergistic antibacterial and wound healing promotion
Int J Biol Macromol. 2024 Apr 14:131549. doi: 10.1016/j.ijbiomac.2024.131549. Online ahead of print.ABSTRACTAfter skin tissue trauma, wound infections caused by bacteria posed a great threat to skin repair. However, resistance to antibiotics, the current treatment of choice for bacterial infections, greatly affected the efficiency of anti-infection and wound healing. Therefore, there has been a critical need for the development of novel antimicrobial materials and advanced therapeutic methods to aid in skin repair. In this paper, rGO-PDA@ZIF-8 nanofillers were prepared by coating graphene oxide (GO) with dopamine (DA), fol...
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Xianyu Lan Hang Yang Yuzhu Xiong Guanyue Zeng Fuping Dong Source Type: research
Design, optimization and pharmaceutical characterization of wound healing film dressings with chloramphenicol and ibuprofen
CONCLUSIONS: The QbD approach was successfully implemented to develop and optimize a novel film dressing promising for the treatment of low-exuding acute wounds prone to infection and inflammation.PMID:38622817 | DOI:10.1080/03639045.2024.2339306 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - April 16, 2024 Category: Drugs & Pharmacology Authors: Ioana Savencu Sonia Iurian C ătălina Bogdan Nicoleta Sp înu Maria Suciu Anca Pop Alexandru Țoc Ioan Tomu ță Source Type: research
In vitro evaluation of bone cell response to novel 3D-printable nanocomposite biomaterials for bone reconstruction
J Biomed Mater Res A. 2024 Apr 15. doi: 10.1002/jbm.a.37719. Online ahead of print.ABSTRACTCritically-sized segmental bone defects represent significant challenges requiring grafts for reconstruction. 3D-printed synthetic bone grafts are viable alternatives to structural allografts if engineered to provide appropriate mechanical performance and osteoblast/osteoclast cell responses. Novel 3D-printable nanocomposites containing acrylated epoxidized soybean oil (AESO) or methacrylated AESO (mAESO), polyethylene glycol diacrylate, and nanohydroxyapatite (nHA) were produced using masked stereolithography. The effects of volume ...
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Zahra Haghpanah Dibakar Mondal Nikan Momenbeitollahi Sadaf Mohsenkhani Kiyoumars Zarshenas Yutong Jin Michael Watson Thomas Willett Maud Gorbet Source Type: research
In vitro evaluation of bone cell response to novel 3D-printable nanocomposite biomaterials for bone reconstruction
J Biomed Mater Res A. 2024 Apr 15. doi: 10.1002/jbm.a.37719. Online ahead of print.ABSTRACTCritically-sized segmental bone defects represent significant challenges requiring grafts for reconstruction. 3D-printed synthetic bone grafts are viable alternatives to structural allografts if engineered to provide appropriate mechanical performance and osteoblast/osteoclast cell responses. Novel 3D-printable nanocomposites containing acrylated epoxidized soybean oil (AESO) or methacrylated AESO (mAESO), polyethylene glycol diacrylate, and nanohydroxyapatite (nHA) were produced using masked stereolithography. The effects of volume ...
Source: Biomed Res - April 15, 2024 Category: Research Authors: Zahra Haghpanah Dibakar Mondal Nikan Momenbeitollahi Sadaf Mohsenkhani Kiyoumars Zarshenas Yutong Jin Michael Watson Thomas Willett Maud Gorbet Source Type: research
Coarse-grained modeling and dynamics tracking of nanoparticles diffusion in human gut mucus
Int J Biol Macromol. 2024 Apr 11:131434. doi: 10.1016/j.ijbiomac.2024.131434. Online ahead of print.ABSTRACTThe gastrointestinal (GI) tract's mucus layer serves as a critical barrier and a mediator in drug nanoparticle delivery. The mucus layer's diverse molecular structures and spatial complexity complicates the mechanistic study of the diffusion dynamics of particulate materials. In response, we developed a bi-component coarse-grained mucus model, specifically tailored for the colorectal cancer environment, that contained the two most abundant glycoproteins in GI mucus: Muc2 and Muc5AC. This model demonstrated the effect...
Source: International Journal of Biological Macromolecules - April 13, 2024 Category: Biochemistry Authors: Liming Zhao Sandra L Arias Warren Zipfel Ilana L Brito Jingjie Yeo Source Type: research
AgNPs loaded adenine-modified chitosan composite POSS-PEG hybrid hydrogel with enhanced antibacterial and cell proliferation properties for promotion of infected wound healing
Int J Biol Macromol. 2024 Apr 11:131575. doi: 10.1016/j.ijbiomac.2024.131575. Online ahead of print.ABSTRACTWound healing is a dynamic and complex process, it's urgent to develop new wound dressings with excellent performance to promote wound healing at the different stages. Here, a novel composite hydrogel dressing composed by silver nanoparticles (AgNPs) impregnated adenine-modified chitosan (CS-A) and octafunctionalized polyhedral oligomeric silsesquioxane (POSS) of benzaldehyde-terminated polyethylene glycol (POSS-PEG-CHO) solution was presented to solve the problem of wound infection. Modification of chitosan with ade...
Source: International Journal of Biological Macromolecules - April 13, 2024 Category: Biochemistry Authors: Cong Zhou Tao Jiang Siju Liu Yingjie He Guichun Yang Junqi Nie Feiyi Wang Xiaofan Yang Zhenbing Chen Cuifen Lu Source Type: research
Comparison of the solid-phase red cell adherence assay and tube method for detection and identification of red blood cell antibodies
CONCLUSIONS: To our knowledge, this is the first robust, 15-year study comparing methodologic sensitivity to detect clinically significant alloantibodies. The incidence of discordant results between PEG-IAT and the solid-phase technique was low. Among discordant samples, anti-Jka was commonly detected using the solid-phase method but not with the PEG-IAT. In contrast, anti-E was commonly detected by PEG-IAT but not by the solid-phase method.PMID:38607807 | DOI:10.1093/ajcp/aqae035 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 12, 2024 Category: Pathology Authors: Mohamed Abdelmonem Alex Dussaq Kathy Papakonstantino Muharrem Yunce Mrigender Singh Virk Source Type: research
Continuous Synthesis of a Macrocyclic Sulfite of Polyethylene Glycol by Cascaded Continuous Stirred Tank Reactors (CSTRs)
Chemistry. 2024 Apr 12:e202401026. doi: 10.1002/chem.202401026. Online ahead of print.ABSTRACTInvited for the cover of this issue is the group of Long Pan and co-workers at Asymchem Life Sciences (Tianjin) Co. Ltd. The image depicts a novel continuous process for the synthesis of a macrocyclic poly(ethylene glycol) (PEG) sulfite, the precursor to PEG macrocyclic sulfate, a useful building block in PEG chemistry. Read the full text of the article at 10.1002/chem.202304319.PMID:38607283 | DOI:10.1002/chem.202401026 (Source: Chemistry)
Source: Chemistry - April 12, 2024 Category: Chemistry Authors: Jichang Wei Yinli Liu Yuchen Sun Jun Bai He Gao Zhaojun Yang Long Pan Source Type: research
Comparison of the solid-phase red cell adherence assay and tube method for detection and identification of red blood cell antibodies
CONCLUSIONS: To our knowledge, this is the first robust, 15-year study comparing methodologic sensitivity to detect clinically significant alloantibodies. The incidence of discordant results between PEG-IAT and the solid-phase technique was low. Among discordant samples, anti-Jka was commonly detected using the solid-phase method but not with the PEG-IAT. In contrast, anti-E was commonly detected by PEG-IAT but not by the solid-phase method.PMID:38607807 | DOI:10.1093/ajcp/aqae035 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 12, 2024 Category: Pathology Authors: Mohamed Abdelmonem Alex Dussaq Kathy Papakonstantino Muharrem Yunce Mrigender Singh Virk Source Type: research
