Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
VEGF and Runx2 mRNA Delivered by Nanomicelle Accelerate Bone Regeneration
In this study, to produce additive angiogenic-osteogenic effects in the process of bone regeneration, VEGF and Runt-related transcription factor 2 (Runx2), an essential transcription factor for osteogenic differentiation, were coadministered with messenger RNAs (mRNAs) to bone defects in the rat mandible.
The mRNAs were administered to a bone defect prepared in the rat mandible using our original cationic polymer-based carrier, the polyplex nanomicelle. The bone regeneration was evaluated by micro-computerized tomography (μCT) imaging, and histologic analyses.
Osteogenic markers such as osteocalcin (Ocn) and...
Source: Fight Aging! - August 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn
A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect
How to Construct Measures of Biological Age
A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls
In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals
Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome
Intestinal Barrier Dysfunction as a Feature of Aging in Many Species
NAFLD as an Age-Related Condition
Towards Sensory Hair Cell Regeneration in the Inner Ear
Raised Leve...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrially Targeted Lipid Nanoparticles as a Delivery System
This study reports on an attempt to establish a system for delivering an antioxidant molecule CoQ10 to mitochondria and the validation of its therapeutic efficacy in a model of acetaminophen liver injury caused by oxidative stress in mitochondria. A CoQ10-MITO-Porter, a mitochondrial targeting lipid nanoparticle (LNP) containing encapsulated CoQ10, was prepared using a microfluidic device. It was essential to include polyethylene glycol (PEG) in the lipid composition of this LNP to ensure stability of the CoQ10, since it is relatively insoluble in water.
Based on transmission electron microscope observations and sma...
Source: Fight Aging! - May 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Pop-Up Electrode for Improved Neural Interfaces
Researchers at Penn State designed a pop-up electrode for brain monitoring and other applications requiring neural interfacing. The pop-up design starts life as a folded two-dimensional structure with a rigid outer coating that makes it easy to insert into the brain. Once in place, the hard coating dissolves, revealing a softer and more flexible material that is less likely to cause tissue damage. The device can unfold, like the structures in children’s pop-up books, to form a surface electrode array and four penetrating shanks that can measure signals from deeper within the neural tissue. The researchers hope that the d...
Source: Medgadget - February 3, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Neurology Neurosurgery PennState Source Type: blogs
Protein Coating Protects Nanoparticles from Immune Attack
Researchers at the University of Pennsylvania School of Medicine have created a new coating for nanoparticles that can help to protect them from attacks by the immune system. The approach, which uses naturally occurring proteins that can inhibit the complement system, can significantly reduce immune destruction of nanoparticles, meaning that more may reach their target tissue. Aside from the potential to increase the effectiveness of nanotherapies, the coating may also be useful for medical devices, such as stents and catheters.
Nanoparticles offer huge potential in delivering drugs or vaccines right to the tissue ...
Source: Medgadget - January 17, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Nanomedicine @PennHealthTech @PennMedicine @SUBiodesign upenn Source Type: blogs
Pancreatic Organoids Grown Inside Synthetic Gel
A team at MIT has developed a technique to grow organoids, both from healthy and cancerous pancreatic tissue, using a synthetic gel that predictably mimics the pancreatic extracellular environment. Compared with naturally derived materials, the synthetic gel is consistent from batch to batch, meaning that it leads to more reproducible and predictable results when growing organoids. The MIT researchers hope that the technology could advance organoid research, both pancreatic and otherwise.
Cancerous pancreatic tissues are not easy to grow and study in the lab, as they lose their cancerous characteristics relatively quick...
Source: Medgadget - September 23, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Oncology Source Type: blogs
DNA Origami to Trap Viruses Inside Body
Researchers at the Technical University of Munich have developed a method to create tiny virus traps that can bind viral particles and render them harmless within the body. The technique relies on DNA origami to create self-assembling hollow nanocapsules, which are lined with molecules that will bind viruses and prevent them from leaving. With a viral pandemic currently running riot, such technologies should be very welcome for the future.
Effective anti-viral drugs are elusive for many viral infections, COVID-19 being no exception. These researchers have developed a new type of anti-viral technology that does not rely ...
Source: Medgadget - July 19, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Materials Medicine Nanomedicine Source Type: blogs
RNA, in a Nutshell
The mRNA vaccine platform is based on decades of previous studies, highlighting the importance of regularly funding basic research. (Source: virology blog)
Source: virology blog - January 7, 2021 Category: Virology Authors: Trudy Rey Tags: Basic virology Gertrud Rey cancer mRNA vaccines cholesterol encapsulated lipid nanoparticle PEG polyethylene glycol pre-fusion spike protein rsv SARS-CoV-2 Source Type: blogs
Ending Constipation from Suboxone and Buprenorphine
Constipation is one of the few potential side effects caused by buprenorphine medications, including Suboxone Film and Zubsolv. Fortunately, ‘binding up’ can be managed by making minor changes to your lifestyle.
Constipation from buprenorphine is caused by activation of mu opioid receptors in the small and large intestine, reducing the sequential squeezing and relaxation (called peristalsis) that pushes bowel contents forward. All opioids have similar effects, mimicking our natural endorphins throughout the body. Endorphins are released during trauma to naturally block pain and to divert blood flow to areas...
Source: Suboxone Talk Zone - October 28, 2020 Category: Addiction Authors: admin Tags: Uncategorized Source Type: blogs
New Customizable Bio-Ink for Printing Organs, Tissues
3D printing of tissues and organs requires a bio-ink that can host the living cells that are required for every unique application. A viable construct requires an extracellular matrix that will have the right mechanical and biochemical properties for the intended cells.
Researchers at Rutgers University believe they’re on track to being able to print a wide variety of tissues and organs thanks to a bio-ink that can be fine tuned so that living cells placed within structures printed using it will find comfort and proliferate as desired.
The team used hyaluronic acid, a common biomolecule, and polyethylene glyc...
Source: Medgadget - February 11, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Cardiac Surgery Genetics Materials News Plastic Surgery Vascular Surgery Source Type: blogs
Bone Bandage Soaks up Adenosine Molecules to Repair Hard Tissue
Researchers from Duke University have developed a bone bandage that accumulates pro-healing adenosine molecules to accelerate bone repair.
Bone fractures are complex, difficult injuries resulting in prolonged and sometimes incomplete repair. One way of approaching new treatments for bone fractures involves delivering new bone cells, which can promote healing. Yet, delivering these cells is limited by the challenge of high costs and limited engraftment of transplanted cells. As an alternate approach, the Duke researchers developed a method to mobilize bone tissue to augment its healing abilities thanks to a special biom...
Source: Medgadget - December 18, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Materials Orthopedic Surgery Source Type: blogs
CRISPR-Responsive Materials Deliver Therapy on Biological Cues
CRISPR gene editing is a technique famous for its potential to edit the genomes of living organisms, including humans. Using the technique, it may be possible to reverse congenital conditions, kill off viruses, and do things previously only imagined. But now it has been employed to do something else entirely, and that is to give materials the ability to change their properties when specific DNA sequences are nearby.
The MIT and Harvard team behind the new research developed a variety of devices based on the new technology, including gels that release drugs, an electronic circuit that reacts to DNA cues, and a microfluid...
Source: Medgadget - August 29, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Genetics Materials Medicine Nanomedicine Oncology Pathology Source Type: blogs
New Biomaterial Improves Brain Cancer Survival in Rats
Researchers from the University of Nottingham have developed a new biomaterial that delivers chemotherapies to treat brain cancer. Their work demonstrates that their biodegradable paste led to increased survival compared to controls, and that half of all rats in a study were clear of any cancer as confirmed by laboratory tests. This exciting development may one day improve treatment options for glioblastoma patients, as well as those with other cancers.
Surgery is commonly performed to try to fight glioblastoma. Yet, one of the major challenges is that despite careful surgical removal of the tumor, some cancer cells may...
Source: Medgadget - July 24, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Materials Medicine Neurosurgery Oncology Source Type: blogs
Nano-emulsions for Drug Delivery Through Skin
Researchers from MIT have developed a new chemical nanoemulsion that can help deliver drugs through the skin. Their work demonstrates that, only by using a handful of FDA-approved materials, they can create nano-sized emulsions which turn to gels when they come in contact with the body. These nano-emulsions may have interesting properties for drug delivery through the skin, or perhaps even the nose.
Emulsions are droplets of one liquid suspended in another liquid, like an oil-and-vinegar salad dressing. Mixing these two liquids in a controlled manner can produce nano-sized droplets, which may have superior uptake proper...
Source: Medgadget - June 28, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Materials Medicine Nanomedicine News Source Type: blogs
