Adipose derived stem cells loaded photocurable and bioprintable bioinks composed of GelMA, HAMA and PEGDA crosslinker to differentiate into smooth muscle phenotype
Int J Biol Macromol. 2024 Mar 14:130710. doi: 10.1016/j.ijbiomac.2024.130710. Online ahead of print.ABSTRACTDeveloping a polymer-based photocrosslinked 3D printable scaffolds comprised of gelatin methacryloyl (G) and hyaluronic acid methacryloyl (H) incorporated with two molecular weights of polyethylene glycol diacrylate (P) of various concentrations that enables rabbit adipose-derived stem cells (rADSCs) to survive, grow, and differentiate into smooth muscle cells (SMCs). Then, the chemical modification and physicochemical properties of the PGH bioinks were evaluated. The cell viability was assessed via MTT, CCK-8 assay ...
Source: International Journal of Biological Macromolecules - March 16, 2024 Category: Biochemistry Authors: Pavanchandh Atturu Sunaina Mudigonda Chau-Zen Wang Shun-Cheng Wu Jhen-Wei Chen Mary Fornica Francis Forgia Hans-Uwe Dahms Chih-Kuang Wang Source Type: research
Eudragit S100 coated nanodiamond-based nanoparticles as an oral chemo-photothermal delivery system for local treatment of colon cancer
Colloids Surf B Biointerfaces. 2024 Mar 13;237:113849. doi: 10.1016/j.colsurfb.2024.113849. Online ahead of print.ABSTRACTOral colonic nano-drug delivery system has received more and more attention in the treatment of colon cancer due to local precision treatment and reduction of drug system distribution. However, the complex and harsh gastrointestinal environment and the retention of nanoparticles in the colon limit its development. To this end, we designed Eudragit S100 (ES) coated nanoparticles (ES@PND-PEG-TPP/DOX). Polydopamine coated nanodiamond (PND) was modified with amino-functionalized polyethylene glycol (NH2-PEG...
Source: Colloids and Surfaces - March 16, 2024 Category: Biotechnology Authors: Yupei Su Hao Pan Jiahui Wang Dandan Liu Weisan Pan Source Type: research
Eudragit S100 coated nanodiamond-based nanoparticles as an oral chemo-photothermal delivery system for local treatment of colon cancer
Colloids Surf B Biointerfaces. 2024 Mar 13;237:113849. doi: 10.1016/j.colsurfb.2024.113849. Online ahead of print.ABSTRACTOral colonic nano-drug delivery system has received more and more attention in the treatment of colon cancer due to local precision treatment and reduction of drug system distribution. However, the complex and harsh gastrointestinal environment and the retention of nanoparticles in the colon limit its development. To this end, we designed Eudragit S100 (ES) coated nanoparticles (ES@PND-PEG-TPP/DOX). Polydopamine coated nanodiamond (PND) was modified with amino-functionalized polyethylene glycol (NH2-PEG...
Source: Colloids and Surfaces - March 16, 2024 Category: Biotechnology Authors: Yupei Su Hao Pan Jiahui Wang Dandan Liu Weisan Pan Source Type: research
Synergistic effect of mesoporous silica nanocarrier-assisted photodynamic therapy and anticancer agent activity on lung cancer cells
This study aims to explore the combined effects of photodynamic and anticancer treatments using a multifunctional nanocarrier system co-administering the photosensitizer IR780 and the anticancer agent curcumin (Cur) on lung cancer cells. Nanocarriers were prepared by encapsulation IR780 and Cur inside polyethylene glycol-capped mesoporous silica nanoparticles (Cur&IR780@MSN). Various concentrations of nanocarriers were evaluated on A549 cells following 5 min NIR laser light (continuous wave, 785 nm, 500 mW/cm2) irradiation. The internalization of nanocarriers was observed through the fluorescence of Cur. Changes in ...
Source: Lasers in Medical Science - March 16, 2024 Category: Laser Surgery Source Type: research
Efficacy, tolerability, and safety of oral sulfate tablet versus 2 L-polyethylene glycol/ascorbate for bowel preparation in older patients: prospective, multicenter, investigator single-blinded, randomized study
ConclusionsOST is an effective and safe low-volume agent for colonoscopy, with better tolerance than 2 L-PEG/Asc, in older individuals aged ≥ 70 years. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 16, 2024 Category: Gastroenterology Source Type: research
The effect of triglycerol diacrylate on the printability and properties of UV curable, bio-based nanohydroxyapatite composites
This study demonstrates the development of bio-based additive manufacturing feedstocks for potential uses in sustainable manufacturing, rapid prototyping, and biomaterial applications.PMID:38490049 | DOI:10.1016/j.jmbbm.2024.106499 (Source: Journal of the Mechanical Behavior of Biomedical Materials)
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 15, 2024 Category: Materials Science Authors: Elizabeth V Diederichs Dibakar Mondal Haresh Patil Maud Gorbet Thomas L Willett Source Type: research
The effect of triglycerol diacrylate on the printability and properties of UV curable, bio-based nanohydroxyapatite composites
This study demonstrates the development of bio-based additive manufacturing feedstocks for potential uses in sustainable manufacturing, rapid prototyping, and biomaterial applications.PMID:38490049 | DOI:10.1016/j.jmbbm.2024.106499 (Source: Journal of the Mechanical Behavior of Biomedical Materials)
Source: Journal of the Mechanical Behavior of Biomedical Materials - March 15, 2024 Category: Materials Science Authors: Elizabeth V Diederichs Dibakar Mondal Haresh Patil Maud Gorbet Thomas L Willett Source Type: research
Italian guidelines for the management of irritable bowel syndrome in children and adolescents
AbstractThe irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), whose prevalence has widely increased in pediatric population during the past two decades. The exact pathophysiological mechanism underlying IBS is still uncertain, thus resulting in challenging diagnosis and management. Experts from 4 Italian Societies participated in a Delphi consensus, searching medical literature and voting process on 22 statements on both diagnosis and management of IBS in children. Recommendations and levels of evidence were evaluated according to the grading of recommendations, assessment, development, and e...
Source: Italian Journal of Pediatrics - March 14, 2024 Category: Pediatrics Source Type: research
Development of lactic acid based chain extender and soybean oil-derived polyurethanes for ecofriendly sustained drug delivery systems
Int J Biol Macromol. 2024 Mar 11:130717. doi: 10.1016/j.ijbiomac.2024.130717. Online ahead of print.ABSTRACTIn the present study, a range of sustainable, biocompatible and biodegradable polyurethanes (PU-1 to PU-4) were synthesized using different combinations of biobased polyol (obtained through the epoxidation of soybean oil, followed by ring opening with ethanol) and polyethylene glycol (PEG) and isophorone diisocyanate. The sustainable chain extender used in this study was synthesized by the esterification of lactic acid with ethylene glycol (EG). The synthesized PU samples were characterized through scanning electron ...
Source: International Journal of Biological Macromolecules - March 13, 2024 Category: Biochemistry Authors: Amer Iqbal Muhammad Asif Javaid Muhammad Tahir Hussain Zulfiqar Ali Raza Source Type: research
Development of lactic acid based chain extender and soybean oil-derived polyurethanes for ecofriendly sustained drug delivery systems
Int J Biol Macromol. 2024 Mar 11:130717. doi: 10.1016/j.ijbiomac.2024.130717. Online ahead of print.ABSTRACTIn the present study, a range of sustainable, biocompatible and biodegradable polyurethanes (PU-1 to PU-4) were synthesized using different combinations of biobased polyol (obtained through the epoxidation of soybean oil, followed by ring opening with ethanol) and polyethylene glycol (PEG) and isophorone diisocyanate. The sustainable chain extender used in this study was synthesized by the esterification of lactic acid with ethylene glycol (EG). The synthesized PU samples were characterized through scanning electron ...
Source: International Journal of Biological Macromolecules - March 13, 2024 Category: Biochemistry Authors: Amer Iqbal Muhammad Asif Javaid Muhammad Tahir Hussain Zulfiqar Ali Raza Source Type: research
Effect of Trimethylamine-N-oxide on the Phase Separation of Aqueous Polyethylene Glycol-600-Dextran-75 Two-Phase Systems
Phys. Chem. Chem. Phys., 2024, Accepted Manuscript DOI: 10.1039/D3CP06200G, PaperAmber Titus, Patrick Herron, Kiril Streletzky, Pedro P Madeira, Vladimir N. Uversky, Boris Zaslavsky The emergence of phase separation in both intracellular biomolecular condensates (membrane-less organelles) and in vitro aqueous two-phase systems (ATPS) rely on the formation of immiscible water-based phases/domains. The solvent properties... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - March 13, 2024 Category: Chemistry Authors: Amber Titus Source Type: research
The miR166 targets CsHDZ3 genes to negatively regulate drought tolerance in tea plant (Camellia sinensis)
Int J Biol Macromol. 2024 Mar 10:130735. doi: 10.1016/j.ijbiomac.2024.130735. Online ahead of print.ABSTRACTDrought is the stressor with a significant adverse impact on the yield stability of tea plants. HD-ZIP III transcription factors (TFs) play important regulatory roles in plant growth, development, and stress responses. However, whether and how HD-ZIP III TFs are involved in drought response and tolerance in tea plants remains unclear. Here, we identified seven HD-ZIP III genes (CsHDZ3-1 to CsHDZ3-7) in tea plant genome. The evolutionary analysis demonstrated that CsHDZ3 members were subjected to purify selection. Sub...
Source: International Journal of Biological Macromolecules - March 12, 2024 Category: Biochemistry Authors: Chengzhe Zhou Niannian Yang Caiyun Tian Shengjing Wen Cheng Zhang Anru Zheng Xiaowen Hu Jiaxin Fang Zhendong Zhang Zhongxiong Lai Yuling Lin Yuqiong Guo Source Type: research
Engineered biodegradable nanopesticides for efficient leaf deposition and plant fungicides
AbstractPesticides are indispensable in agricultural development, but their effectiveness is often hindered by natural factors like rain-off and degradation. Herein, tebuconazole nanopesticides (TEB NPs) with leaf-adhesive, water-stable, and small-sized were successfully prepared by flash nanoprecipitation using the biodegradable polyethylene glycol-b-poly (lactic-co-glycolic acid) as a carrier. The nanopesticides could be efficiently deposited on plant leaves with uniform distribution and exhibited a 14 ° lower contact angle with foliage compared to commercial suspensions. The encapsulation of TEB within the polymer enha...
Source: AIChE Journal - March 11, 2024 Category: Science Authors: Xiaojing Tong,
Jie Tang,
Jia Wang,
Yue Wu,
Zhiyuan Zheng,
Chen Yuan,
A. Basak Kayitmazer,
Ayyaz Ahmad,
Naveed Ramzan,
Jintao Yang,
Qingchun Huang,
Yisheng Xu Tags: RESEARCH ARTICLE Source Type: research
NiCo2O4 Nanowires Immobilized on Nitrogen ‐Doped Ti3C2Tx for High‐Performance Wearable Magnesium–Air Batteries
A high-performance flexible Mg –air battery is demonstrated with powering blue flexible light-emitting diode (LED) arrays and red smart rollable wearable device in practical applications. Through low over-potential NiCo2O4 nanowires well immobilized on nitrogen-doped Ti3C2Tx, the efficient oxygen electrode contributes to significantly boost oxygen diffusion and delivers high power density of 9.8 mW cm–2. AbstractFlexible magnesium (Mg) –air batteries provide an ideal platform for developing efficient energy-storage devices toward wearable electronics and bio-integrated power sources. However, high-capacity bio-adap...
Source: Small - March 10, 2024 Category: Nanotechnology Authors: Aniu Qian,
Miaomiao Cui,
Yue Sun,
Guangyu Wang,
Yuehui Hao,
Chengli Yang,
Hu Shi Tags: Research Article Source Type: research
