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Lactols from Physalis grisea
Fitoterapia. 2022 Oct 22:105340. doi: 10.1016/j.fitote.2022.105340. Online ahead of print.ABSTRACTFrom the extracts of stems and leaves as well as of calyxes of Physalis grisea were isolated four withalactols, the new griselactols A (3) and B (6) and the known physapubescin (1) and peruvianolide E (2). Other four known compounds were also isolated, kaempferol 3-O-β-sophoroside (5) and three sterols. The structures of compounds were elucidated by extensive spectroscopic data analyses, chemical and physical-chemical methods, including electronic circular dichroism (ECD), and by comparison with data described in the literatu...
Source: Fitoterapia - October 25, 2022 Category: Biochemistry Authors: Ana L P érez-Castorena Antonio Nieto-Camacho Mahinda Mart ínez Emma Maldonado Source Type: research

Antiproliferative potential of Physalis peruviana -derived magnolin against pancreatic cancer: a comprehensive in vitro and in silico study
In conclusion, our results clearly revealed that magnolin derived from P. peruviana is an interesting antiproliferative and antimetastatic agent against PANC-1 cells with potent inhibitory activity against MMP3. Further in vivo evaluation will be of great interest in the future.PMID:36281695 | DOI:10.1039/d2fo01915a (Source: Cancer Control)
Source: Cancer Control - October 25, 2022 Category: Cancer & Oncology Authors: Ahmed M Sayed Seham S El-Hawary Usama Ramadan Abdelmohsen Mosad A Ghareeb Source Type: research

Integrated serum pharmacochemistry and network pharmacology analyses reveal the bioactive metabolites and potential functional mechanism of ground cherry (Physalis pruinosa L.) in treatment of type 2 diabetes mellitus in rats
CONCLUSIONS: The study in hand offers a comprehensive study to clarify the bioactive metabolites of the different organs of P. pruinosa. The basic pharmacological effects and underlying mechanism of actions in the management of STZ and high fat diet induced T2DM were specifically covered in this paper.PMID:36162547 | DOI:10.1016/j.jep.2022.115750 (Source: Atherosclerosis)
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: Asmaa Mahana Hala M Hammoda Asmaa A Khalifa Samar S Elblehi Fathallah M Harraz Eman Shawky Source Type: research

Molecules, Vol. 27, Pages 5787: Chemical Composition Assessment of Structural Parts (Seeds, Peel, Pulp) of Physalis alkekengi L. Fruits
Skrovankova Mlcek In recent years there has been an extensive search for nature-based products with functional potential. All structural parts of Physalis alkekengi (bladder cherry), including fruits, pulp, and less-explored parts, such as seeds and peel, can be considered sources of functional macro- and micronutrients, bioactive compounds, such as vitamins, minerals, polyphenols, and polyunsaturated fatty acids, and dietetic fiber. The chemical composition of all fruit structural parts (seeds, peel, and pulp) of two phenotypes of P. alkekengi were studied. The seeds were found to be a rich source of oil, yieldin...
Source: Molecules - September 7, 2022 Category: Chemistry Authors: Popova Petkova Mazova Ivanova Petkova Stoyanova Stoyanova Ercisli Okcu Skrovankova Mlcek Tags: Article Source Type: research

Constituent Composition of Physalis angulata
Total alkaloids (0.6%) were isolated from the aerial part ofPhysalis angulata. The known alkaloids cuscohygrine and tropine were identified for the first time in it. Neutral and polar lipids from seeds and fatty acids from leaves ofP. angulata were characterized. Neutral (12.35%) and polar lipids (2.18%) were isolated from seeds. Their fatty-acid compositions (16 –17 constituents) were determined. Leaves contained 3.6% total lipids with a fatty-acid composition like that of the plant seeds. Seeds and leaves ofP. angulata were studied for carbohydrate contents. Leaves were shown to contain water-soluble polysaccharides an...
Source: Chemistry of Natural Compounds - August 12, 2022 Category: Chemistry Source Type: research

Viruses, Vol. 14, Pages 1676: Spillover of a Tobamovirus from the Australian Indigenous Flora to Invasive Weeds
phen J. Wylie The tobamovirus yellow tailflower mild mottle virus (YTMMV) was previously reported in wild plants of Anthocercis species (family Solanaceae) and other solanaceous indigenous species growing in natural habitats in Western Australia. Here, we undertook a survey of two introduced solanaceous weeds, namely Solanum nigrum (black nightshade) and Physalis peruviana (cape gooseberry) in the Perth metropolitan area and surrounds to determine if YTMMV has spread naturally to these species. At a remnant natural bushland site where both solanaceous weeds and indigenous Anthocercis hosts grew adjacent to one another,...
Source: Viruses - July 29, 2022 Category: Virology Authors: Weinan Xu Hua Li Krishnapillai Sivasithamparam Dieu Thi Tran Michael G. K. Jones Xin Chen Stephen J. Wylie Tags: Brief Report Source Type: research

Two new withanolides from the whole plants of Physalis peruviana 
J Asian Nat Prod Res. 2022 Jul 7:1-8. doi: 10.1080/10286020.2022.2095263. Online ahead of print.ABSTRACTTwo new withaphysalin-type withanolides (18-O-ethylwithaphysalin R and 5-O-ethylphysaminimin C, 1 and 2), along with twelve known withanolides (3-14), were purified and identified from Physalis peruviana L. The chemical structures of these new isolates were elucidated through analyzing spectroscopic and HRESIMS data. All the obtained metabolites were appraised for their potential antiproliferative activity against the human breast cancer cell line MCF-7. Compound 7 was discovered to exhibit potent activity with an IC50 v...
Source: Cell Research - July 7, 2022 Category: Cytology Authors: Qian-Ran Li Hui-Jun Liang Bai-Lin Li Zhuo-Yi Ao Yu-Wen Fan Wei-Jie Zhang Xin Lian Jia-Yan Chen Juan-Juan Hu Jie Yuan Jie-Wei Wu Source Type: research

Two new withanolides from the whole plants of Physalis peruviana
. (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - July 7, 2022 Category: Complementary Medicine Authors: Qian-Ran Li Hui-Jun Liang Bai-Lin Li Zhuo-Yi Ao Yu-Wen Fan Wei-Jie Zhang Xin Lian Jia-Yan Chen Juan-Juan Hu Jie Yuan Jie-Wei Wu Source Type: research

Molecules, Vol. 27, Pages 4238: QTOF-ESI MS Characterization and Antioxidant Activity of Physalis peruviana L. (Cape Gooseberry) Husks and Fruits from Costa Rica
In this study, the profile of compounds found in fruits and husks from Costa Rica was determined through ultra-performance liquid chromatography coupled with high-resolution mass spectrometry using a quadrupole time-of-flight analyzer (UPLC-ESI-QTOF MS) on extracts (n = 10) obtained through pressurized liquid extraction (PLE) conditions. In total, 66 different compounds were identified, comprising 34 withanolides, 23 sucrose ester derivatives and 9 flavonoids. UPLC-DAD analysis was performed to determine the &beta;-carotene in fruits and to quantify the flavonoids in all 10 samples, with the results showing higher ...
Source: Molecules - June 30, 2022 Category: Chemistry Authors: Mirtha Navarro-Hoyos Elizabeth Arn áez-Serrano Mar ía Isabel Quirós-Fallas Felipe Vargas-Huertas Krissia Wilhelm-Romero Felipe V ásquez-Castro Diego Alvarado-Corella Andr és Sánchez-Kopper Tags: Article Source Type: research

Natural infection of cape gooseberry (Physalis peruviana) by the potyvirus Tamarillo leaf malformation virus (TaLMV)
Acta Virol. 2022;66(2):174-181. doi: 10.4149/av_2022_211.ABSTRACTTamarillo leaf malformation virus (TaLMV) is a potyvirus first discovered in cape gooseberry fields in Eastern, and South-western Antioquia. This virus is responsible for a very damaging disease that has resulted in significant reductions in yields and cultivated area for this crop in Colombia. Tamarillo is frequently co-cultivated with other solanaceous plants but no evidence for cross-pathogenicity of TaLMV has been found until now. In this work, we report a natural infection of cape gooseberry (Physalis peruviana L.) by TaLMV. Infection by TaLMV was detect...
Source: Acta Virologica - June 29, 2022 Category: Infectious Diseases Authors: Erika Corrales-Cabra Andrea Restrepo Escobar M ónica Higuita Valencia Yuliana Gallo Garc ía Mauricio Mar ín Montoya Pablo Guti érrez Sánchez Source Type: research