Research on the Chemical Constituents against Alzheimer's Disease of the Fruits of Physalis alkekengi L. var. franchetii (Mast.) Makino
This study reveals that PAF can reduce neuroinflammatory damage by inhibiting p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway, which is the theoretical basis for clinical development and utilization of PAF in AD therapy.PMID:37505462 | DOI:10.1002/cbdv.202301075 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - July 28, 2023 Category: Biochemistry Authors: Yang Teng Qi Yuan You Wu Shuang Wu Jin Su Pengxia Zhang Yu Zhang Source Type: research
Research on the Chemical Constituents against Alzheimer's Disease of the Fruits of Physalis alkekengi L. var. franchetii (Mast.) Makino
This study reveals that PAF can reduce neuroinflammatory damage by inhibiting p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway, which is the theoretical basis for clinical development and utilization of PAF in AD therapy.PMID:37505462 | DOI:10.1002/cbdv.202301075 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - July 28, 2023 Category: Biochemistry Authors: Yang Teng Qi Yuan You Wu Shuang Wu Jin Su Pengxia Zhang Yu Zhang Source Type: research
Physalis pubescens L. branch and leaf extracts inhibit lymphoma proliferation by inducing apoptosis and cell cycle arrest
In conclusion, PHY-EA has a good antiproliferative effect on Burkkit lymphoma, indicating its potential medicinal value. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - July 24, 2023 Category: Drugs & Pharmacology Source Type: research
A comprehensive quality evaluation method of different medicinal parts of Physalis Calyx seu Fructus by fingerprints, chemometrics, antioxidant activity, network pharmacology and molecular docking
Biomed Chromatogr. 2023 Jul 5:e5701. doi: 10.1002/bmc.5701. Online ahead of print.ABSTRACTPhysalis Calyx seu Fructus (PCF) is a herb widely used in China for its function of clearing heat and detoxifying, benefitting the pharynx and reducing phlegm, both in health care and in tea drinking. However, the quality of its fruit and calyx is uneven and the storage period is short. Therefore, it is crucial to develop other parts of PCF with longer storage periods and obvious medicinal effects. Firstly, high-performance liquid chromatography was used to develop the fingerprint of different parts of PCF, and various chemometric ana...
Source: Biomedical Chromatography : BMC - July 5, 2023 Category: Biomedical Science Authors: Meiqi Liu Guoqiang Liu Zicheng Ma Jin Li Wen Yi Liu Lili Sun Xiaoliang Ren Source Type: research
A comprehensive quality evaluation method of different medicinal parts of Physalis Calyx seu Fructus by fingerprints, chemometrics, antioxidant activity, network pharmacology and molecular docking
Biomed Chromatogr. 2023 Jul 5:e5701. doi: 10.1002/bmc.5701. Online ahead of print.ABSTRACTPhysalis Calyx seu Fructus (PCF) is a herb widely used in China for its function of clearing heat and detoxifying, benefitting the pharynx and reducing phlegm, both in health care and in tea drinking. However, the quality of its fruit and calyx is uneven and the storage period is short. Therefore, it is crucial to develop other parts of PCF with longer storage periods and obvious medicinal effects. Firstly, high-performance liquid chromatography was used to develop the fingerprint of different parts of PCF, and various chemometric ana...
Source: Biomedical Chromatography : BMC - July 5, 2023 Category: Biomedical Science Authors: Meiqi Liu Guoqiang Liu Zicheng Ma Jin Li Wen Yi Liu Lili Sun Xiaoliang Ren Source Type: research
A comprehensive quality evaluation method of different medicinal parts of Physalis Calyx seu Fructus by fingerprints, chemometrics, antioxidant activity, network pharmacology and molecular docking
Biomed Chromatogr. 2023 Jul 5:e5701. doi: 10.1002/bmc.5701. Online ahead of print.ABSTRACTPhysalis Calyx seu Fructus (PCF) is a herb widely used in China for its function of clearing heat and detoxifying, benefitting the pharynx and reducing phlegm, both in health care and in tea drinking. However, the quality of its fruit and calyx is uneven and the storage period is short. Therefore, it is crucial to develop other parts of PCF with longer storage periods and obvious medicinal effects. Firstly, high-performance liquid chromatography was used to develop the fingerprint of different parts of PCF, and various chemometric ana...
Source: Biomedical Chromatography : BMC - July 5, 2023 Category: Biomedical Science Authors: Meiqi Liu Guoqiang Liu Zicheng Ma Jin Li Wen Yi Liu Lili Sun Xiaoliang Ren Source Type: research
A comprehensive quality evaluation method of different medicinal parts of Physalis Calyx seu Fructus by fingerprints, chemometrics, antioxidant activity, network pharmacology and molecular docking
Biomed Chromatogr. 2023 Jul 5:e5701. doi: 10.1002/bmc.5701. Online ahead of print.ABSTRACTPhysalis Calyx seu Fructus (PCF) is a herb widely used in China for its function of clearing heat and detoxifying, benefitting the pharynx and reducing phlegm, both in health care and in tea drinking. However, the quality of its fruit and calyx is uneven and the storage period is short. Therefore, it is crucial to develop other parts of PCF with longer storage periods and obvious medicinal effects. Firstly, high-performance liquid chromatography was used to develop the fingerprint of different parts of PCF, and various chemometric ana...
Source: Biomedical Chromatography : BMC - July 5, 2023 Category: Biomedical Science Authors: Meiqi Liu Guoqiang Liu Zicheng Ma Jin Li Wen Yi Liu Lili Sun Xiaoliang Ren Source Type: research
Golden berry leaf extract containing withanolides suppresses TNF- α and IL-17 induced IL-6 expression in HeLa Cells
In this study, we established an experimental system for overexpression of IL-6 in HeLa cells stimulated by TNF-α and IL-17, along with identification of anti-inflammatory materials and components from local agricultural, forestry, and fishery resources. We constructed a library of extracts from natural sources, of which 111 samples were evaluated for their anti-inflammatory activities. The MeOH extract of Golden Berry (Physalis peruviana L) leaf was found to exhibit strong anti-inflammatory properties (IC50 = 4.97 µg/mL). Preparative chromatography identified two active constituents, 4β-hydroxywithanolide E (4β-HWE) (...
Source: Bioscience, Biotechnology, and Biochemistry - June 6, 2023 Category: Biochemistry Authors: Akira Yano Sayaka Yuki Akiko Shiraishi Mayuka Hakozaki Yuko Kanno Kimura Ken-Ichi Shota Uesugi Source Type: research
Golden berry leaf extract containing withanolides suppresses TNF- α and IL-17 induced IL-6 expression in HeLa Cells
In this study, we established an experimental system for overexpression of IL-6 in HeLa cells stimulated by TNF-α and IL-17, along with identification of anti-inflammatory materials and components from local agricultural, forestry, and fishery resources. We constructed a library of extracts from natural sources, of which 111 samples were evaluated for their anti-inflammatory activities. The MeOH extract of Golden Berry (Physalis peruviana L) leaf was found to exhibit strong anti-inflammatory properties (IC50 = 4.97 µg/mL). Preparative chromatography identified two active constituents, 4β-hydroxywithanolide E (4β-HWE) (...
Source: Bioscience, Biotechnology, and Biochemistry - June 6, 2023 Category: Biochemistry Authors: Akira Yano Sayaka Yuki Akiko Shiraishi Mayuka Hakozaki Yuko Kanno Kimura Ken-Ichi Shota Uesugi Source Type: research
Golden berry leaf extract containing withanolides suppresses TNF- α and IL-17 induced IL-6 expression in HeLa Cells
In this study, we established an experimental system for overexpression of IL-6 in HeLa cells stimulated by TNF-α and IL-17, along with identification of anti-inflammatory materials and components from local agricultural, forestry, and fishery resources. We constructed a library of extracts from natural sources, of which 111 samples were evaluated for their anti-inflammatory activities. The MeOH extract of Golden Berry (Physalis peruviana L) leaf was found to exhibit strong anti-inflammatory properties (IC50 = 4.97 µg/mL). Preparative chromatography identified two active constituents, 4β-hydroxywithanolide E (4β-HWE) (...
Source: Bioscience, Biotechnology, and Biochemistry - June 6, 2023 Category: Biochemistry Authors: Akira Yano Sayaka Yuki Akiko Shiraishi Mayuka Hakozaki Yuko Kanno Kimura Ken-Ichi Shota Uesugi Source Type: research
Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (VIII): six new withanolides from Physalis philadelphica
In this study, we attempted to isolate their active compounds against MT-1 and MT-2 from extracts ofP. philadelphica. We identified 13 withanolides, including six newly isolated compounds [24R, 25S-4 β, 16β, 20R-trihydroxy-1-oxowitha-2-en-5 β, 6 β -epoxy-22,26-olide (1), 4 β, 7β,20R-trihydroxy-1-oxowitha-2-en-5 β, 6β -epoxy-22,26-olide (2), 17 β,20S-dihydroxywithanone (3), 2,3-dihydro-3 β-methoxy-23β-hydroxywithaphysacarpin (4), 3-O-(4-rhamnosyl)glucosyl-physalolactone B (5), and 17R, 20R, 22S, 23S, 24R, 25R-4 β, 5α, 6β, 20β, 22α -tetrahydroxy-16β, 23-diepoxy-1-oxowitha-2-en-26, 23-olide (6)], from the ext...
Source: Journal of Natural Medicines - May 18, 2023 Category: Drugs & Pharmacology Source Type: research
Case Report: Unusual Bullous Reaction to Physalia physalis Venom after Recurrent Envenomation
We report on two clinic visits of a patient who suffered from worsening reactions to recurrent P. physalis envenomation. The first clinical episode involved urticaria and severe pruritus that was worse than the pruritus the patient had experienced upon envenomation in the past. The second episode involved an unusual bullous reaction. Further study into the compounds present in P. physalis venom may help elucidate the mechanism of the present case and other abnormal reactions to envenomation. Patients and providers who care for patients at risk for recurrent stings (e.g., surfers, fishermen) should be cognizant of the poten...
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Kevin Yang Jeffrey D Klausner Source Type: research
Case Report: Unusual Bullous Reaction to Physalia physalis Venom after Recurrent Envenomation
We report on two clinic visits of a patient who suffered from worsening reactions to recurrent P. physalis envenomation. The first clinical episode involved urticaria and severe pruritus that was worse than the pruritus the patient had experienced upon envenomation in the past. The second episode involved an unusual bullous reaction. Further study into the compounds present in P. physalis venom may help elucidate the mechanism of the present case and other abnormal reactions to envenomation. Patients and providers who care for patients at risk for recurrent stings (e.g., surfers, fishermen) should be cognizant of the poten...
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Kevin Yang Jeffrey D Klausner Source Type: research
Case Report: Unusual Bullous Reaction to Physalia physalis Venom after Recurrent Envenomation
We report on two clinic visits of a patient who suffered from worsening reactions to recurrent P. physalis envenomation. The first clinical episode involved urticaria and severe pruritus that was worse than the pruritus the patient had experienced upon envenomation in the past. The second episode involved an unusual bullous reaction. Further study into the compounds present in P. physalis venom may help elucidate the mechanism of the present case and other abnormal reactions to envenomation. Patients and providers who care for patients at risk for recurrent stings (e.g., surfers, fishermen) should be cognizant of the poten...
Source: Am J Trop Med Hyg - May 9, 2023 Category: Infectious Diseases Authors: Kevin Yang Jeffrey D Klausner Source Type: research
Case Report: Unusual Bullous Reaction to Physalia physalis Venom after Recurrent Envenomation
We report on two clinic visits of a patient who suffered from worsening reactions to recurrent P. physalis envenomation. The first clinical episode involved urticaria and severe pruritus that was worse than the pruritus the patient had experienced upon envenomation in the past. The second episode involved an unusual bullous reaction. Further study into the compounds present in P. physalis venom may help elucidate the mechanism of the present case and other abnormal reactions to envenomation. Patients and providers who care for patients at risk for recurrent stings (e.g., surfers, fishermen) should be cognizant of the poten...
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Kevin Yang Jeffrey D Klausner Source Type: research
