Characterization of Withania somnifera chloroplast genome and its comparison with other selected species of Solanaceae.
Abstract
Withania somnifera (L) Dunal, a wonder herb of family Solanaceae, has multiple medicinal properties. Here, we reported the chloroplast genome sequence of Withania somnifera (154,386 bp) which comprises of a large single copy region (85,688 bp), and a small single copy region (18,464 bp), separated by a pair of large inverted repeats (25,117 bp). The chloroplast genome has 132 genes including 86 protein-coding, 37 tRNAs and 8 rRNAs. Comparison of chloroplast genomes of Withania somnifera with four other Solanaceae species revealed similarities in genomic features, including structure, nucle...
Source: Genomics - August 26, 2019 Category: Genetics & Stem Cells Authors: Mehmood F, Abdullah, Shahzadi I, Ahmed I, Waheed MT, Mirza B Tags: Genomics Source Type: research
Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L.
Abstract
Withanolides are steroidal lactones widespread in Nightshade plants with often potent antiproliferative activities. Additionally, the structural diversity of this compound class holds much potential for the discovery of novel biological activity. Here, we report two newly characterised withanolides, named irinans, from Physalis peruviana with highly unusual truncated backbones that resemble mammalian androstane sex hormones. Based on biomimetic chemical reactions, we propose a model that links these compounds to withanolide biosynthesis. Irinans have potent antiproliferative activities, that are however lower than...
Source: Beilstein Journal of Organic Chemistry - August 23, 2019 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: androstanes Physalis peruviana steroids structure elucidation withanolides Full Research Paper Source Type: research
[ASAP] Labdanes, Withanolides, and Other Constituents from < italic toggle="yes" > Physalis nicandroides < /italic >
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b00233 (Source: Journal of Natural Products)
Source: Journal of Natural Products - August 20, 2019 Category: Biochemistry Authors: Fernando R. Torres †, Ana L. Pe´rez-Castorena†, Laura Arredondo†, Rube´n A. Toscano†, Antonio Nieto-Camacho†, Mahinda Marti´nez‡, and Emma Maldonado*† Source Type: research
A polysaccharide isolated from the fruits of Physalis alkekengi L. induces RAW264.7 macrophages activation via TLR2 and TLR4-mediated MAPK and NF- κB signaling pathways.
A polysaccharide isolated from the fruits of Physalis alkekengi L. induces RAW264.7 macrophages activation via TLR2 and TLR4-mediated MAPK and NF-κB signaling pathways.
Int J Biol Macromol. 2019 Aug 20;:
Authors: Yang F, Li X, Yang Y, Ayivi-Tosuh SM, Wang F, Li H, Wang G
Abstract
Polysaccharides from Physalis alkekengi L. have been proven to possess many biological activities. In our previous study, a homogeneous polysaccharide (PPSB) was extracted and purified from the fruits of Physalis alkekengi L., and the structure characterization was analyzed. The present study aimed to in...
Source: International Journal of Biological Macromolecules - August 19, 2019 Category: Biochemistry Authors: Yang F, Li X, Yang Y, Ayivi-Tosuh SM, Wang F, Li H, Wang G Tags: Int J Biol Macromol Source Type: research
Identification Of Potential Cytotoxic Inhibitors From Physalis Minima.
Abstract
A phytochemical investigation of Physalis minima led to the isolation of six withanolides, including withanolide E (1), withaperuvin C (2), 4β-hydroxywithanolide E (3), 28-hydroxywithaperuvin C (4), physaperuvin G (5), and 4-deoxywithaperuvin (6). Their chemical structures were elucidated by 1 D-NMR and 2 D-NMR data, as well as comparison with the data reported in the literature. All isolated compounds were evaluated for their cytotoxic activity against HepG2, SK-LU-1, and MCF7 cancer cell lines. As the obtained results, compounds 1 and 3 displayed the strongest cytotoxicity against HepG2, SK...
Source: Natural Product Research - August 11, 2019 Category: Biochemistry Authors: Le Canh VC, Le Ba V, Thi Hai Yen P, Le Thi L, Thi Thuy Hoai P, Huu Dat TT, Thao DT, Bach LG, Kim YH, Tuan Anh HL Tags: Nat Prod Res Source Type: research
Two new 3-hexenol glycosides from the calyces of Physalis alkekengi var. franchetii.
Abstract
Two new hexenol glycosides, (Z)-hex-3-en-1-ol O-β-d-xylcopyranosyl-(1-6)-β -d-glucopyranosyl-(1-2)-β-d-glucopyranoside (1) and (E)-hex-3-en-1-ol O-β-d-xylcopyranosyl-(1-6)-β-d-glucopyranosyl-(1-2)-β-d-glucopyranoside (2), were isolated from the 50% ethanol elution of macroporous resin of Physalis alkekengi var. franchetii. Their structures were established by detailed spectroscopic analysis, including extensive 2D-NMR data. This is the first time to report the (Z) and (E) 3-hexenol glycosides from Physalis alkekengi var. franchetii.
PMID: 31343265 [PubMed - as supplied by publisher] ...
Source: Natural Product Research - July 24, 2019 Category: Biochemistry Authors: Shu Z, Tang Y, Yang Y, Ding Z, Zhong R, Xia T, Li X, Zheng C, Wen Z, Li W, Wang Y Tags: Nat Prod Res Source Type: research
The effect of the presence of seeds on the nutraceutical, sensory and rheological properties of Physalis spp. fruits jam: a comparative analysis
Publication date: Available online 6 July 2019Source: Food ChemistryAuthor(s): Aleyda Pérez-Herrera, Gabino A. Martínez-Gutiérrez, Frank M. León-Martínez, Marco A. Sánchez-MedinaAbstractFour jams were made using two wild species of Physalis spp., two containing seeds (P1WS and P2WS) and two without seeds (P1WHS and P2WHS). Physicochemical, nutraceutical and rheological properties of the jams were determined and a sensory evaluation made. P1WS and P2WS jams had lower carbohydrates contents, reducing sugars and calories, and higher fiber contents than P1WHS and P2WHS. The presence of seeds in the jams increased phenols...
Source: Food Chemistry - July 7, 2019 Category: Food Science Source Type: research
Withaminimas A—F, six withanolides with potential anti-inflammatory activity from Physalis minima
Publication date: June 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 6Author(s): Shan-Shan WEI, Cai-Yun GAO, Rui-Jun LI, Ling-Yi KONG, Jun LUOAbstractWithaminimas A—F (1—6), six new withaphysalin-type withanolides were isolated from the aerial parts of Physalis minima L.. The structures of these compounds were elucidated through a variety of spectroscopic techniques including HR-MS, NMR, and ECD. Compound 1 belongs to rare 18-norwithanolides, and 2—3 were 13/14-secowithanolides. According to the traditional usage of P. minima, inhibitory effects on nitric oxide (NO) production in lipopolysaccarid...
Source: Chinese Journal of Natural Medicines - June 29, 2019 Category: Complementary Medicine Source Type: research
New Phenolic Glycosides from Physalis angulata.
Authors: Anh HLT, Dung DT, Tuan DT, Tai BH, Nhiem NX, Yen PH, Duc TM, Binh PQ, Nam NH, Minh CV, Kiem PV
Abstract
Two new phenolic glycosides, physangulosides A and B (1 and 2), were isolated from the whole plant of Physalis angulata. Their chemical structures were determined by mean of HR-ESI-MS, lD, and 2D-NMR spectra. Both of the compounds showed weak protection against hydrogen peroxide induced hepatocytes damage.
PMID: 30508351 [PubMed - indexed for MEDLINE] (Source: Natural Product Communications)
Source: Natural Product Communications - June 15, 2019 Category: Biochemistry Tags: Nat Prod Commun Source Type: research
Two new physalin derivatives from Physalis alkekengi L. var. franchetii (Mast.) Makino.
Abstract
Two new physalin derivatives named 7β-ethoxyl-isophysalin C (1) and 3β-ethoxyl-2,3-dihydro-4,7-didehydrophysalin B (2) were isolated from Physalis alkekengi L. var. franchetii (Mast.) Makino. Their structures were determined by extensive NMR-spectroscopic analysis and HRESIMS data. Compounds 1 and 2 were tested for their cytotoxicity against PC-3 cancer cell lines. Compound 1 showed apparent moderate with IC50 values of 8.26 μM, whereas compound 2 exhibited no cytotoxicity against PC-3 cancer cell lines.
PMID: 31140313 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - May 28, 2019 Category: Biochemistry Authors: Sun JL, Jiang YJ, Cheng L Tags: Nat Prod Res Source Type: research
A biomass carbon material with microtubule bundling and natural O-doping derived from goldenberry calyx and its electrochemical performance in supercapacitor
Publication date: Available online 25 May 2019Source: Chinese Chemical LettersAuthor(s): Yang Liu, Mengyi Zhang, Liqiu Wang, Yajuan Hou, Chenxiao Guo, Haiying Xin, Shuang XuAbstractA promising biomass carbon material, manufactured by the carbonation of Physalis peruviana L. calyx at 700 °C, is presented in this work. Morphology characterization shows that the carbon material possesses long microtubule bundling and above 30% natural O-atom component on the surface. After KOH chemical etching, the materials maintain the oxygen content but exhibit more micropores and higher specific surface area up to 1732.6 m2/g. Using as...
Source: Chinese Chemical Letters - May 25, 2019 Category: Chemistry Source Type: research
[ASAP] Physalis Mottle Virus-like Nanoparticles for Targeted Cancer Imaging
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.9b03956 (Source: ACS Applied Materials and Interfaces)
Source: ACS Applied Materials and Interfaces - May 10, 2019 Category: Materials Science Authors: He Hu, Hema Masarapu, Yuning Gu, Yifan Zhang, Xin Yu, Nicole F. Steinmetz Source Type: research
Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymes
Physalin A isolated from Physalis alkekengi var. franchetii has been known to have many pharmacological properties. However, its effect through the Nrf2 pathway has not yet been elucidated. In the present study, ... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - May 9, 2019 Category: Complementary Medicine Authors: Ji Min Shin, Kyung-Mi Lee, Hee Ju Lee, Ji Ho Yun and Chu Won Nho Tags: Research article Source Type: research
Molecules, Vol. 24, Pages 1608: Cytotoxic Withanolides from the Whole Herb of Physalis angulata L.
ia Liu
Erbing Hua
Physalis angulata L. is a medicinal plant of the Solanaceae family, which is used to produce a variety of steroids. The present study reports on the cytotoxic withanolides of this plant. The species of Physalis angulata L. was identified by DNA barcoding techniques. Two new withanolides (1&ndash;2), together with six known analogues (3&ndash;8), were isolated from the whole plant of Physalis angulata L. The structures of these new compounds were determined on the basis of extensive spectroscopic data analyses and electronic circular dichroism (ECD) calculations. The withanolides exhi...
Source: Molecules - April 22, 2019 Category: Chemistry Authors: Qinghong Meng Jiajia Fan Zhiguo Liu Xiwen Li Fangbo Zhang Yanlin Zhang Yi Sun Li Li Xia Liu Erbing Hua Tags: Article Source Type: research
Molecules, Vol. 24, Pages 1146: Physalis peruviana-Derived 4 β-Hydroxywithanolide E, a Novel Antagonist of Wnt Signaling, Inhibits Colorectal Cancer In Vitro and In Vivo
In conclusion, our study suggested that 4&beta;HWE could be of potential use in anti-tumor agent development as a novel Wnt signaling inhibitor. (Source: Molecules)
Source: Molecules - March 21, 2019 Category: Chemistry Authors: Zhen-Nan Ye Feng Yuan Jie-Qing Liu Xing-Rong Peng Tao An Xue Li Ling-Mei Kong Ming-Hua Qiu Yan Li Tags: Article Source Type: research
