Identification Of Potential Cytotoxic Inhibitors From Physalis Minima.

Identification Of Potential Cytotoxic Inhibitors From Physalis Minima. Nat Prod Res. 2019 Aug 12;:1-4 Authors: Le Canh VC, Le Ba V, Thi Hai Yen P, Le Thi L, Thi Thuy Hoai P, Huu Dat TT, Thao DT, Bach LG, Kim YH, Tuan Anh HL Abstract A phytochemical investigation of Physalis minima led to the isolation of six withanolides, including withanolide E (1), withaperuvin C (2), 4β-hydroxywithanolide E (3), 28-hydroxywithaperuvin C (4), physaperuvin G (5), and 4-deoxywithaperuvin (6). Their chemical structures were elucidated by 1 D-NMR and 2 D-NMR data, as well as comparison with the data reported in the literature. All isolated compounds were evaluated for their cytotoxic activity against HepG2, SK-LU-1, and MCF7 cancer cell lines. As the obtained results, compounds 1 and 3 displayed the strongest cytotoxicity against HepG2, SK-LU-1, and MCF7 cell lines with IC50 value ranging from 0.051 ± 0.004 to 0.86 ± 0.09 μg/mL. PMID: 31402707 [PubMed - as supplied by publisher]
Source: Natural Product Research - Category: Biochemistry Authors: Tags: Nat Prod Res Source Type: research