In vitro inhibition of 5- α reductase and in vivo suppression of benign prostatic hyperplasia by Physalis angulata ethyl acetate extract
Fitoterapia. 2024 Apr 8:105950. doi: 10.1016/j.fitote.2024.105950. Online ahead of print.ABSTRACTThe inhibitory effect against 5-α reductase of the ethyl acetate (EA) extract from Physalis angulata was evaluated in vitro using mouse prostate homogenates, and the suppression of benign prostatic hyperplasia (BPH) was assessed in a mouse model of testosterone-induced BPH. The EA extract exhibited a potentially inhibitory effect on 5-α reductase with an IC50 of 197 μg/ml. In BPH mice, the EA extract at a dose of 12 mg/kg was comparable to finasteride 5 mg/kg in suppressing BPH in terms of reducing absolute enlarged prostate...
Source: Fitoterapia - April 10, 2024 Category: Biochemistry Authors: Ngoc Phuc Nguyen Quoc Giang Le Vinh Nghi Truong Thi Ngoc Dung Nguyen Nguyen Truong Thang Phan Manh Hung Tran Source Type: research
New steroids with anti-inflammatory activity from the whole plants of < em > Physalis minima < /em >
Nat Prod Res. 2024 Apr 10:1-7. doi: 10.1080/14786419.2024.2340048. Online ahead of print.ABSTRACTTwo new steroids, phyminiolide J (1) and phyministerol A (2), along with three known compounds (3-5) were isolated from the whole plants of Physalis minima. The structures of the new compounds were elucidated by comprehensive spectroscopic analysis and the absolute configurations were determined by using computational ECD calculations. All isolates were evaluated for their anti-inflammatory activity via inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells, and t...
Source: Natural Product Research - April 10, 2024 Category: Biochemistry Authors: Jiangping Wu Qiuyue Lv Jie Yu Yu Zhang Guodong Wang Jun Han Zhongmei Zou Source Type: research
New steroids with anti-inflammatory activity from the whole plants of < em > Physalis minima < /em >
Nat Prod Res. 2024 Apr 10:1-7. doi: 10.1080/14786419.2024.2340048. Online ahead of print.ABSTRACTTwo new steroids, phyminiolide J (1) and phyministerol A (2), along with three known compounds (3-5) were isolated from the whole plants of Physalis minima. The structures of the new compounds were elucidated by comprehensive spectroscopic analysis and the absolute configurations were determined by using computational ECD calculations. All isolates were evaluated for their anti-inflammatory activity via inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells, and t...
Source: Natural Product Research - April 10, 2024 Category: Biochemistry Authors: Jiangping Wu Qiuyue Lv Jie Yu Yu Zhang Guodong Wang Jun Han Zhongmei Zou Source Type: research
Two new sesquiterpenoid glycoside compounds from the calyces of Physalis alkekengi L. var. franchetii (Mast.) Makino
. (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - March 22, 2024 Category: Complementary Medicine Authors: Yang TengXiang-Rong ZhangXiao-Lei LiJia GaoLei NiGuan-Qun Zhana College of Pharmacy, Jiamusi University, Jiamusi 154007, Chinab School of Pharmacy, Health Science Center, Xi ’an Jiaotong University, Xi’an 710049, China Source Type: research
Effect of saline stress on the metabolic profile and antidiabetic potential of < em > Physalis peruviana < /em >
This study aimed to evaluate the effects of applying NaCl (0, 10, 20, 30, and 40 mM) to goldenberry plants on the metabolite profile and hypoglycaemic potential of both fruit and leaf decoctions. The findings demonstrated that NaCl increases the phenolic content, flavonoids, and hydrolysable polyphenols in leaf decoctions. Additionally, four alkaloids previously unreported in Physalis peruviana were identified. Saline stress improved the profile of extractable and non-extractable phenolic compounds in both leaves and fruits. Furthermore, incubation with decoctions of stressed leaves at a concentration of 0.50 mg/mL reduced...
Source: Natural Product Research - March 19, 2024 Category: Biochemistry Authors: Nayely Gonz ález-Buenrostro Iza F P érez-Ramírez Ofelia Mora Alejandro Rios-Lozano Ma Estela V ázquez-Barrios Rosal ía Reynoso-Camacho Marely G Figueroa-P érez Source Type: research
Effect of saline stress on the metabolic profile and antidiabetic potential of < em > Physalis peruviana < /em >
This study aimed to evaluate the effects of applying NaCl (0, 10, 20, 30, and 40 mM) to goldenberry plants on the metabolite profile and hypoglycaemic potential of both fruit and leaf decoctions. The findings demonstrated that NaCl increases the phenolic content, flavonoids, and hydrolysable polyphenols in leaf decoctions. Additionally, four alkaloids previously unreported in Physalis peruviana were identified. Saline stress improved the profile of extractable and non-extractable phenolic compounds in both leaves and fruits. Furthermore, incubation with decoctions of stressed leaves at a concentration of 0.50 mg/mL reduced...
Source: Natural Product Research - March 19, 2024 Category: Biochemistry Authors: Nayely Gonz ález-Buenrostro Iza F P érez-Ramírez Ofelia Mora Alejandro Rios-Lozano Ma Estela V ázquez-Barrios Rosal ía Reynoso-Camacho Marely G Figueroa-P érez Source Type: research
Withaperuvin O, a new withanolide from < em > Physalis peruviana < /em > L
In this study, a new withanolide named withaperuvin O (1) and seven known ones, including physalolactone B-3-O-β-D-glucopyranoside (2), withanolide J (3), physapruin A (4), physaperuvin G (5), withaperuvin (6), withaperuvin C (7) and 28-hydroxywithaperuvin C (8), were isolated from the whole plants of P. peruviana. Their structures were elucidated based on extensive spectroscopic analyses including NMR and HR-ESI-MS. The bioactivities of these compounds against lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells and cytotoxicity against HepG2 were tested. Compound 3 showed strong anti-inflammatory activities ...
Source: Cell Research - March 1, 2024 Category: Cytology Authors: Pham Van Cong Vu Thi Trang Le Quynh Lien Vu Xuan Hoan Tran Minh Ngoc Do Thanh Tuan Do Thi Thu Hien Ngo Van Hieu Ngo Viet Duc Hoang Le Tuan Anh Source Type: research
Withaperuvin O, a new withanolide from < em > Physalis peruviana < /em > L
In this study, a new withanolide named withaperuvin O (1) and seven known ones, including physalolactone B-3-O-β-D-glucopyranoside (2), withanolide J (3), physapruin A (4), physaperuvin G (5), withaperuvin (6), withaperuvin C (7) and 28-hydroxywithaperuvin C (8), were isolated from the whole plants of P. peruviana. Their structures were elucidated based on extensive spectroscopic analyses including NMR and HR-ESI-MS. The bioactivities of these compounds against lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells and cytotoxicity against HepG2 were tested. Compound 3 showed strong anti-inflammatory activities ...
Source: Cancer Control - March 1, 2024 Category: Cancer & Oncology Authors: Pham Van Cong Vu Thi Trang Le Quynh Lien Vu Xuan Hoan Tran Minh Ngoc Do Thanh Tuan Do Thi Thu Hien Ngo Van Hieu Ngo Viet Duc Hoang Le Tuan Anh Source Type: research
Withaperuvin O, a new withanolide from < em > Physalis peruviana < /em > L
In this study, a new withanolide named withaperuvin O (1) and seven known ones, including physalolactone B-3-O-β-D-glucopyranoside (2), withanolide J (3), physapruin A (4), physaperuvin G (5), withaperuvin (6), withaperuvin C (7) and 28-hydroxywithaperuvin C (8), were isolated from the whole plants of P. peruviana. Their structures were elucidated based on extensive spectroscopic analyses including NMR and HR-ESI-MS. The bioactivities of these compounds against lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells and cytotoxicity against HepG2 were tested. Compound 3 showed strong anti-inflammatory activities ...
Source: Natural Product Research - March 1, 2024 Category: Biochemistry Authors: Pham Van Cong Vu Thi Trang Le Quynh Lien Vu Xuan Hoan Tran Minh Ngoc Do Thanh Tuan Do Thi Thu Hien Ngo Van Hieu Ngo Viet Duc Hoang Le Tuan Anh Source Type: research
Withaperuvin O, a new withanolide from < em > Physalis peruviana < /em > L
In this study, a new withanolide named withaperuvin O (1) and seven known ones, including physalolactone B-3-O-β-D-glucopyranoside (2), withanolide J (3), physapruin A (4), physaperuvin G (5), withaperuvin (6), withaperuvin C (7) and 28-hydroxywithaperuvin C (8), were isolated from the whole plants of P. peruviana. Their structures were elucidated based on extensive spectroscopic analyses including NMR and HR-ESI-MS. The bioactivities of these compounds against lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells and cytotoxicity against HepG2 were tested. Compound 3 showed strong anti-inflammatory activities ...
Source: Cell Research - March 1, 2024 Category: Cytology Authors: Pham Van Cong Vu Thi Trang Le Quynh Lien Vu Xuan Hoan Tran Minh Ngoc Do Thanh Tuan Do Thi Thu Hien Ngo Van Hieu Ngo Viet Duc Hoang Le Tuan Anh Source Type: research
Withaperuvin O, a new withanolide from < em > Physalis peruviana < /em > L
In this study, a new withanolide named withaperuvin O (1) and seven known ones, including physalolactone B-3-O-β-D-glucopyranoside (2), withanolide J (3), physapruin A (4), physaperuvin G (5), withaperuvin (6), withaperuvin C (7) and 28-hydroxywithaperuvin C (8), were isolated from the whole plants of P. peruviana. Their structures were elucidated based on extensive spectroscopic analyses including NMR and HR-ESI-MS. The bioactivities of these compounds against lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells and cytotoxicity against HepG2 were tested. Compound 3 showed strong anti-inflammatory activities ...
Source: Natural Product Research - March 1, 2024 Category: Biochemistry Authors: Pham Van Cong Vu Thi Trang Le Quynh Lien Vu Xuan Hoan Tran Minh Ngoc Do Thanh Tuan Do Thi Thu Hien Ngo Van Hieu Ngo Viet Duc Hoang Le Tuan Anh Source Type: research
Withaperuvin O, a new withanolide from < em > Physalis peruviana < /em > L
In this study, a new withanolide named withaperuvin O (1) and seven known ones, including physalolactone B-3-O-β-D-glucopyranoside (2), withanolide J (3), physapruin A (4), physaperuvin G (5), withaperuvin (6), withaperuvin C (7) and 28-hydroxywithaperuvin C (8), were isolated from the whole plants of P. peruviana. Their structures were elucidated based on extensive spectroscopic analyses including NMR and HR-ESI-MS. The bioactivities of these compounds against lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells and cytotoxicity against HepG2 were tested. Compound 3 showed strong anti-inflammatory activities ...
Source: Natural Product Research - March 1, 2024 Category: Biochemistry Authors: Pham Van Cong Vu Thi Trang Le Quynh Lien Vu Xuan Hoan Tran Minh Ngoc Do Thanh Tuan Do Thi Thu Hien Ngo Van Hieu Ngo Viet Duc Hoang Le Tuan Anh Source Type: research
Viruses, Vol. 16, Pages 267: Meta-Transcriptomic Analysis Uncovers the Presence of Four Novel Viruses and Multiple Known Virus Genera in a Single Hibiscus rosa-sinensis Plant in Colombia
ohn Hammond
Hibiscus is not native to Colombia but well suited to its arid soil and dry climates. A single hibiscus plant from Risaralda, showing black spots on upper and lower sides of its leaves, was collected for virome analysis using meta-transcriptomic high-throughput sequencing technology. Bioinformatic analysis identified 12.5% of the total reads in the Ribo-Zero cDNA library which mapped to viral genomes. BLAST searches revealed the presence of carlavirus, potexvirus, and of known members of the genera Betacarmovirus, Cilevirus, Nepovirus, and Tobamovirus in the sample; confirmed by RT-PCR with virus-specific p...
Source: Viruses - February 7, 2024 Category: Virology Authors: Avijit Roy Sam Grinstead Guillermo Leon Mart ínez Juan Carlos Campos Pinz ón Schyler O. Nunziata Chellappan Padmanabhan John Hammond Tags: Article Source Type: research
The Effect of Physalis angulata L. Administration on Gene Expressions Related to Lung Fibrosis Resolution in Mice-Induced Bleomycin
(Source: International Journal of Nanomedicine)
Source: International Journal of Nanomedicine - February 1, 2024 Category: Nanotechnology Tags: Journal of Experimental Pharmacology Source Type: research
Molecules, Vol. 29, Pages 184: Structural Studies of Mexican Husk Tomato (Physalis ixocarpa) Fruit Cutin
-Patiño
Green tomato (Physalis ixocarpa) is a specie native to Mexico, and it is known as &ldquo;tomatillo&rdquo; or &ldquo;husk tomato&rdquo;. The fruit contains vitamins, minerals, phenolic compounds, and steroidal lactones, presenting antimicrobial activity and antinarcotic effects. Therefore, it is not only used in traditional Mexican cuisine, but also in traditional medicine to relieve some discomforts such as fever, cough, and amygdalitis. However, it is a perishable fruit whose shelf life is very short. As a part of the peel, cuticle, and epicuticular waxes represent the most imp...
Source: Molecules - December 28, 2023 Category: Chemistry Authors: Daniel Arrieta-Baez Camila Quezada Huerta Giovana Simone Rojas-Torres Mar ía de Jesús Perea-Flores H éctor Francisco Mendoza-León Mayra Beatriz G ómez-Patiño Tags: Article Source Type: research
