Effect of saline stress on the metabolic profile and antidiabetic potential of < em > Physalis peruviana < /em >

This study aimed to evaluate the effects of applying NaCl (0, 10, 20, 30, and 40 mM) to goldenberry plants on the metabolite profile and hypoglycaemic potential of both fruit and leaf decoctions. The findings demonstrated that NaCl increases the phenolic content, flavonoids, and hydrolysable polyphenols in leaf decoctions. Additionally, four alkaloids previously unreported in Physalis peruviana were identified. Saline stress improved the profile of extractable and non-extractable phenolic compounds in both leaves and fruits. Furthermore, incubation with decoctions of stressed leaves at a concentration of 0.50 mg/mL reduced extracellular glucose levels in 3T3-L1 adipocytes. Moreover, extracts of leaves subjected to 40 mM NaCl stress slightly diminished the postprandial hyperglycaemic peak in healthy rats, potentially attributable to increased glucose uptake in 3T3-L1 adipocytes.PMID:38501737 | DOI:10.1080/14786419.2024.2331608
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research