Withaperuvin O, a new withanolide from < em > Physalis peruviana < /em > L
In this study, a new withanolide named withaperuvin O (1) and seven known ones, including physalolactone B-3-O-β-D-glucopyranoside (2), withanolide J (3), physapruin A (4), physaperuvin G (5), withaperuvin (6), withaperuvin C (7) and 28-hydroxywithaperuvin C (8), were isolated from the whole plants of P. peruviana. Their structures were elucidated based on extensive spectroscopic analyses including NMR and HR-ESI-MS. The bioactivities of these compounds against lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells and cytotoxicity against HepG2 were tested. Compound 3 showed strong anti-inflammatory activities with IC50 3.55 ± 0.12 µM (compared to positive control L-NMMA 7.72 ± 0.46 µM). Compounds 3 and 4 inhibited HepG2 cell line with the IC50 values of 2.01 ± 0.12 µM, 0.96 ± 0.05 µM, respectively (Ellipticine, 0.32 ± 0.02 µM). Our study indicated that compounds 3 and 4 could be new potential natural products for the development of anti-inflammatory and anti-cancer agents.PMID:38426481 | DOI:10.1080/14786419.2024.2323539
Source: Natural Product Research - Category: Biochemistry Authors: Pham Van Cong Vu Thi Trang Le Quynh Lien Vu Xuan Hoan Tran Minh Ngoc Do Thanh Tuan Do Thi Thu Hien Ngo Van Hieu Ngo Viet Duc Hoang Le Tuan Anh Source Type: research