Two new withanolides from the whole plants of < em > Physalis peruviana < /em >

J Asian Nat Prod Res. 2022 Jul 7:1-8. doi: 10.1080/10286020.2022.2095263. Online ahead of print.ABSTRACTTwo new withaphysalin-type withanolides (18-O-ethylwithaphysalin R and 5-O-ethylphysaminimin C, 1 and 2), along with twelve known withanolides (3-14), were purified and identified from Physalis peruviana L. The chemical structures of these new isolates were elucidated through analyzing spectroscopic and HRESIMS data. All the obtained metabolites were appraised for their potential antiproliferative activity against the human breast cancer cell line MCF-7. Compound 7 was discovered to exhibit potent activity with an IC50 value of 3.51 µM and compounds 2, 6 and 14 showed weak cytotoxic effect.PMID:35796599 | DOI:10.1080/10286020.2022.2095263
Source: Cell Research - Category: Cytology Authors: Source Type: research