Passionflower Extract Induces High-amplitude Rhythms without Phase Shifts in the Expression of Several Circadian Clock Genes in Vitro and in Vivo.
Authors: Toda K, Hitoe S, Takeda S, Shimizu N, Shimoda H
Abstract
Circadian rhythms play key roles in the regulation of physiological and behavioral systems including wake-sleep cycles. We evaluated the effects of passionflower (aerial parts of Passiflora incarnata Linnaeus) extract (PFE) on circadian rhythms using NIH3T3 cells and mice. PFE (100 μg/mL) induced high-amplitude rhythms in the expression of period circadian protein (Per) 2, cryptochrome (Cry) 1, superoxide dismutase (SOD) 1, and glutathione peroxidase (GPx) in vitro from 12 h after a treatment with serum-rich medium. Isovitexin 2"-O-glucosid...
Source: International Journal of Biomedical Science - August 23, 2017 Category: Biomedical Science Tags: Int J Biomed Sci Source Type: research
Orally administered Chrysin improves post ‐thawed sperm quality and fertility of rooster
In conclusion, oral Chrysin administration to roosters could ameliorate cryopreservation‐induced impairment of sperm quality and fertility rate. (Source: Reproduction in Domestic Animals)
Source: Reproduction in Domestic Animals - July 10, 2017 Category: Reproduction Medicine Authors: M Zhandi, M Ansari, P Roknabadi, A Zare Shahneh, M Sharafi Tags: ORIGINAL ARTICLE Source Type: research
Standardized Passiflora incarnata L. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats
Passiflora incarnata L. (Passifloraceae) has been traditionally used for treatment of anxiety, insomnia, drug addiction, mild infections, and pain. The aim of this study was to investigate the effect of a commercial extract of P. incarnata in the analgesia induced by alcohol withdrawal syndrome in rats. In addition, brain‐derived neurotrophic factor and interleukin‐10 levels were evaluated in prefrontal cortex, brainstem, and hippocampus. Male adult rats received by oral gavage: (1: water group) water for 19 days, 1 day interval and water (8 days); (2: P. incarnata group) water for 19 days, 1 day interval and P. i...
Source: Phytotherapy Research - June 1, 2017 Category: Biochemistry Authors: Rebeca Vargas Antunes Schunck, Isabel Cristina Macedo, Gabriela Laste, Andressa Souza, Marina Tuerlinckx Costa Valle, Jana ína L.O. Salomón, Ellen Almeida Nunes, Andreia Cristina Wildner Campos, Simone Cristina Baggio Gnoatto, Ana Maria Bergold, Eduardo Tags: Research Article Source Type: research
538 Anti-aging properties of a passion fruit extract, targeted on wrinkle formation
Intrinsic and extrinsic skin aging are cumulative processes that involve molecular initiating events such as oxidative stress and inflammation. This “inflammaging” process is characterized by increased levels of proinflammatory cytokines, resulting in important damages to extracellular matrix and dermal-epidermal junction leading to loss of skin mechanical properties. These modifications result in the formation of wrinkle, one of the most pr ominent signs of aging. We have developed a patented active ingredient from passion fruit, “maracuja oil concentrate”, rich in unsaponifiable fraction, obtained from one of our...
Source: Journal of Investigative Dermatology - April 12, 2017 Category: Dermatology Authors: M. Martin, S. Bredif, J. Rocheteau, G. Bellemere, M. Meloni, C. Moulinet, S. Leclere-bienfait, C. Baudouin Tags: Growth Factors, Cell Adhesion and Matrix Biology Source Type: research
Homeopathy outperforms antibiotics treatment in juvenile scallop Argopecten ventricosus: effects on growth, survival, and immune response.
CONCLUSIONS: Homeopathic treatments improved growth and survival and enhanced survival against V. alginolyticus in juvenile A. ventricosus. This suggests that homeopathy is a viable treatment for this mollusk to reduce use of antibiotics in scallops and its progressive increase in pathogenicity in mollusk hatcheries.
PMID: 28325219 [PubMed - in process] (Source: Homeopathy)
Source: Homeopathy - February 1, 2017 Category: Complementary Medicine Authors: Mazón-Suástegui JM, García-Bernal M, Saucedo PE, Campa-Córdova Á, Abasolo-Pacheco F Tags: Homeopathy Source Type: research
Herbal medicines in children with attention deficit hyperactivity disorder (ADHD): A systematic review.
CONCLUSION: While there is still a lack of sufficient numbers of RCTs no concrete recommendations for use can be made so far.
PMID: 28137522 [PubMed - in process] (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - January 31, 2017 Category: Complementary Medicine Authors: Anheyer D, Lauche R, Schumann D, Dobos G, Cramer H Tags: Complement Ther Med Source Type: research
Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction.
CONCLUSIONS: Passiflora incarnata showed an anxiolytic effect similar to midazolam, and was safe and effective for conscious sedation in adult patients who underwent extraction of their mandibular third molars.
PMID: 27918731 [PubMed - as supplied by publisher] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - December 7, 2016 Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research
114 Stimulating Nrf2 and Heme-Oxygenase 1 pathways to help the skin fighting against daily environmental insults
The skin is routinely exposed to stresses from the environment: pollution, sun … These repeated and regular exposures can profoundly affect skin physiology, and may lead to irreversible consequences. We studied the potential of a maracuja seeds extract, particularly enriched in polyphenols, to enhance skin defense mechanisms involved in environmental stress response. One of the main pathways involved in skin defense and detoxification against environmental stress, involves heme oxygenase 1 (HO1) induction, which is controlled by the Nrf2 transcription factor. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - August 16, 2016 Category: Dermatology Authors: S. Bredif, J. Rocheteau, S. Leclere-Bienfait, C. Moulinet, S. Khaldi, F. Joly, A. Moga, C. Baudouin Tags: Epidermal Structure and Function Source Type: research
Adverse Effects of Plant Food Supplements and Plants Consumed as Food: Results from the Poisons Centres‐Based PlantLIBRA Study
Plant food supplements (PFS) are products of increasing popularity and wide‐spread distribution. Nevertheless, information about their risks is limited. To fill this gap, a poisons centres‐based study was performed as part of the EU project PlantLIBRA. Multicentre retrospective review of data from selected European and Brazilian poisons centres, involving human cases of adverse effects due to plants consumed as food or as ingredients of food supplements recorded between 2006 and 2010. Ten poisons centres provided a total of 75 cases. In 57 cases (76%) a PFS was involved; in 18 (24%) a plant was ingested as food. The 10...
Source: Phytotherapy Research - March 7, 2016 Category: Biochemistry Authors: Saskia Lüde, Sarah Vecchio, Sandra Sinno‐Tellier, Aymeric Dopter, Harriet Mustonen, Slavica Vucinic, Birgitta Jonsson, Dieter Müller, Ligia Veras Gimenez Fruchtengarten, Karl Hruby, Elizabeth De Souza Nascimento, Chiara Di Lorenzo, Patrizia Restani, H Tags: Research Article Source Type: research
Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms
Passiflora incarnata is widely used as an anxiolytic and sedative due to its putative GABAergic properties. Passiflora incarnata L. methanolic extract (PI-ME) was evaluated in an anima... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - February 24, 2016 Category: Complementary Medicine Authors: Urooj Aman, Fazal Subhan, Muhammad Shahid, Shehla Akbar, Nisar Ahmad, Gowhar Ali, Khwaja Fawad and Robert D. E. Sewell Source Type: research
Comparative metabolite profiling and fingerprinting of genus Passiflora leaves using a multiplex approach of UPLC-MS and NMR analyzed by chemometric tools.
Abstract
Passiflora incarnata as well as some other Passiflora species are reported to possess anxiolytic and sedative activity and to treat various CNS disorders. The medicinal use of only a few Passiflora species has been scientifically verified. There are over 400 species in the Passiflora genus worldwide, most of which have been little characterized in terms of phytochemical or pharmacological properties. Herein, large-scale multi-targeted metabolic profiling and fingerprinting techniques were utilized to help gain a broader insight into Passiflora species leaves' chemical composition. Nuclear magnetic...
Source: Analytical and Bioanalytical Chemistry - February 16, 2016 Category: Chemistry Authors: Farag MA, Otify A, Porzel A, Michel CG, Elsayed A, Wessjohann LA Tags: Anal Bioanal Chem Source Type: research
Passiflora incarnata L. Improves Spatial Memory, Reduces Stress, and Affects Neurotransmission in Rats
Passiflora incarnata L. has been used as a medicinal plant in South America and Europe since the 16th century. Previous pharmacological studies focused mainly on the plant's sedative, anxiolytic, and anticonvulsant effects on the central nervous system and its supporting role in the treatment of addiction. The aim of the present study was to evaluate the behavioral and neurochemical effects of long‐term oral administration of P. incarnata. The passionflower extract (30, 100, or 300 mg/kg body weight/day) was given to 4‐week‐old male Wistar rats via their drinking water. Tests were conducted after 7 weeks of treat...
Source: Phytotherapy Research - January 27, 2016 Category: Biochemistry Authors: Katarzyna Jawna‐Zboińska, Kamilla Blecharz‐Klin, Ilona Joniec‐Maciejak, Adriana Wawer, Justyna Pyrzanowska, Agnieszka Piechal, Dagmara Mirowska‐Guzel, Ewa Widy‐Tyszkiewicz Tags: Research Article Source Type: research
Passiflora actinia hydroalcoholic extract and its major constituent, isovitexin, are neuroprotective against glutamate‐induced cell damage in mice hippocampal slices
ConclusionsThis study highlights new neuropharmacological activity of the Passiflora genus, suggesting that it can act as modulator of the glutamatergic system. The search for improved pharmacotherapies with novel mechanisms of action has been shown of great importance for the treatment of resistant neurological and psychiatric disorders. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - January 1, 2016 Category: Drugs & Pharmacology Authors: Kely Cristina Santos, Tatiane Vieira Borges, Gislaine Olescowicz, Fabiana Kalyne Ludka, Cid Aimbiré de Moraes Santos, Simone Molz Tags: Research Paper Source Type: research
Pollen feeding proteomics: salivary proteins of the passion flower butterfly, Heliconius melpomene.
Abstract
While most adult Lepidoptera use flower nectar as their primary food source, butterflies in the genus Heliconius have evolved the novel ability to acquire amino acids from consuming pollen. Heliconius butterflies collect pollen on their proboscis, moisten the pollen with saliva, and use a combination of mechanical disruption and chemical degradation to release free amino acids that are subsequently re-ingested in the saliva. Little is known about the molecular mechanisms of this complex pollen feeding adaptation. Here we report an initial shotgun proteomic analysis of saliva from Heliconius melpom...
Source: Insect Biochemistry and Molecular Biology - May 7, 2015 Category: Biochemistry Authors: Harpel D, Cullen DA, Ott SR, Jiggins CD, Walters JR Tags: Insect Biochem Mol Biol Source Type: research
Revealing Medicinal Plants That Are Useful for the Comprehensive Management of Epilepsy and Associated Comorbidities through In Silico Mining of Their Phytochemical Diversity
In this study, the computer programmes PASS and PharmaExpert were used to reveal the medicinal plants useful in the comprehensive management of epilepsy and associated psychiatric disorders based on the pleiotropic effects predicted for their phytoconstituents. In silico analysis revealed that seven of 50 medicinal plants from traditional Indian medicine possessed the desired pleiotropic effect, i.e., anticonvulsant, antidepressant, and nootropic activities. The majority of phytoconstituents from Passiflora incarnata were concurrently predicted to have the desired pleiotropic effects. Therefore, P. incarnata was pharmacolo...
Source: Planta Medica - April 9, 2015 Category: Drugs & Pharmacology Authors: Goel, Rajesh KumarGawande, DineshLagunin, AlexeyRandhawa, PuneetMishra, AwanishPoroikov, Vladimir Tags: Original Papers Source Type: research
