Vitexin as an active ingredient in passion flower with potential as an agent for nicotine cessation: vitexin antagonism of the expression of nicotine locomotor sensitization in rats.
CONCLUSION: Vitexin should be examined in future studies to evaluate its potential for treating nicotine addiction in humans. PMID: 30707857 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 2, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Patients’ experiences attributed to the use of Passiflora incarnata: A qualitative, phenomenological study
ConclusionThe distinct biographical narratives of the patients associated with their specific experiences of taking Passiflora incarnata provide an additional perspective on the use of Passiflora incarnata as a medicinal plant.Graphical abstractFig. 1: Three types of patient biographical narratives attributed to the experiences of using Passiflora incarnata (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 15, 2018 Category: Drugs & Pharmacology Source Type: research

Pharmaceutical applications of spouted beds: A review on solid dosage forms
Publication date: Available online 4 October 2018Source: ParticuologyAuthor(s): Luís Alexandre Pedro de FreitasAbstractSpouted beds (SBs) have a long history of successful applications for preparation of solid dosage forms of pharmaceuticals. The well-known versatility of SBs, provided by different design and operational factors, and their efficient mixing of solids allow for engineering of technological characteristics of pharmaceutical solid forms. Particle properties like morphology, size, porosity, flowability, and dissolution rate can be improved by managing geometric and operational conditions for spouting. Drying i...
Source: Particuology - October 5, 2018 Category: Science Source Type: research

Evaluation of an early twentieth century Afghan herbalist ’s preparations
AbstractMahomet Allum was a flamboyant philanthropist and herbalist who worked in South Australia in the early part of last century, whose herbal therapies generated some controversy at the time. Two of his preparations have survived to the present day, a general tonic and a treatment for liver and kidney dysfunction. Given the frequent use of pharmaceutical drugs in “tonics” at the time, toxicological analysis was undertaken at Forensic Science SA, Adelaide with liquid chromatography/quadrupole-time-of-flight mass-spectrometer (LC-QTOF MS), liquid-chromatography/ diode array detector (LC/UV) and gas chromatography/ ni...
Source: Forensic Science, Medicine, and Pathology - September 27, 2018 Category: Forensic Medicine Source Type: research

Prevalence of drug-herb and drug-supplement interactions in older adults: a cross-sectional survey.
CONCLUSION: GPs should routinely ask questions regarding herbal and supplement use, to identify and manage older adults at potential risk of adverse drug interactions. PMID: 30249608 [PubMed - as supplied by publisher] (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - September 24, 2018 Category: Primary Care Authors: Agbabiaka TB, Spencer NH, Khanom S, Goodman C Tags: Br J Gen Pract Source Type: research

Comparison of bioactive compounds content in leaf extracts of Passiflora incarnata, P. caerulea and P. alata and in vitro cytotoxic potential on leukemia cell lines
ABSTRACT Passiflora caerulea L., P. alata Curtis and P. incarnata L. (synonym for P. edulis Sims), are the most popular representatives of the Passiflora genus in South America. In recent years, a growing attention is paid to the biological activity and phytochemical profiles of crude extracts from various species of Passiflora in worldwide. The aim of this study was to evaluate and to compare of anti-leukemic activity of the dry crude extracts from leaves of three Passiflora species from greenhouse of Poland in two human acute lymphoblastic leukemia cell lines: CCRF-CEM and its multidrug resistant variant. Two systems of ...
Source: Revista Brasileira de Farmacognosia - June 11, 2018 Category: Drugs & Pharmacology Source Type: research

[Herbal medicines for psychiatric disorders].
CONCLUSION: Due to the promising effects and the low side effect potential within the existing studies, further randomized controlled trials (e. g. for Passiflora incarnata, Rhodiola rosea and Lavendula officinalis) are definitely indicated. PMID: 29846749 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 30, 2018 Category: Neurology Authors: Anheyer D, Haller H, Klose P, Cramer H, Dobos G Tags: Nervenarzt Source Type: research

1414 A new passion fruit extract promoting skin wound healing process
Wound healing is an essential but complex physiological process that involves the collaboration of various cell types and factors. The kinetic of wound healing is divided into 3 phases which overlap: inflammatory phase, repair phase consisting of cell proliferation and migration, and remodeling phase. We have developed a patented active ingredient from passion fruit, maracuja oil concentrate, rich in unsaponifiable fraction, obtained from one of our sustainable supply chains. Evaluated on 2D in vitro models, the extract induced the proliferation and migration of keratinocytes and fibroblasts, and increased hyaluronic acid....
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: G. Boyer, M. Le roux, S. Bredif, G. Bellemere, S. Leclere bienfait, C. Baudouin Tags: Tissue Regeneration and Wound Healing Source Type: research

An open prospective pilot study of a herbal combination "Relief" as a supportive dietetic measure during alcohol withdrawal.
CONCLUSIONS: Despite the limitations of the present study, the findings showed the potential of Relief for the improvement of the clinical situation of patients with symptoms of alcohol withdrawal and therefore, justify a full-scale well-controlled study design to be implemented. PMID: 29604618 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - April 3, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Targeted-Analysis of β-Carboline Alkaloids in Passionfruit (“Maracujá”) by SBSE(PDMS)-LC/Flu and UHPLC-MS
Samples of pulp and seeds of sour (P. edulis) and sweet (P. alata) passionfruit were subjected to targeted analysis to identify β -carboline alkaloids, using combined UHPLC-MS (ultrahigh performance liquid chromatography-mass spectrometry) and SBSE(PDMS) (stir bar sorption extraction using polydimethylsiloxane as stationary phase) for sample preconcentration. All the samples contained harmane and harmine; harmaline was found only in P. alata seeds and in P. edulis pulp, while harmalol was found only in P. alata seeds. An analysis of sweet passionfruit by SBSE(PDMS) combined with LC/Flu (liquid chromatography/fluorescence ...
Source: Journal of the Brazilian Chemical Society - March 15, 2018 Category: Chemistry Source Type: research

Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho ‐oncologic relevance
Anxiety and depression are prevalent among cancer patients, with significant negative impact. Many patients prefer herbs for symptom relief to conventional medications which have limited efficacy/side effects. We identified single‐herb medicines that may warrant further study in cancer patients. Our search included PubMed, Allied and Complementary Medicine, Embase, and Cochrane databases, selecting only single‐herb randomized controlled trials between 1996 and 2016 in any population for data extraction, excluding herbs with known potential for interactions with cancer treatments. One hundred articles involving 38 botan...
Source: Phytotherapy Research - February 21, 2018 Category: Biochemistry Authors: K. Simon Yeung, Marisol Hernandez, Jun J. Mao, Ingrid Haviland, Jyothirmai Gubili Tags: REVIEW Source Type: research

Pregnancy outcomes in psychiatric patients treated with passiflora incarnata.
Abstract Passiflora incarnata is marketed in many countries as anxiolytic herbal supplement. Herbal medicines are natural products, but it doesn't mean they are always safe, especially during pregnancy. Passiflora incarnata extract was not teratogenic in experimental studies. However, there are no data available on possible effects on human pregnancy. Here we report five pregnant women with depression and/or anxiety who used passiflora incarnata in pregnancy. We observed one pregnancy resulting in neonatal death, two pregnancies with premature rupture of membranes, two infants with meconium aspiration synd...
Source: Complementary Therapies in Medicine - February 1, 2018 Category: Complementary Medicine Authors: Ozturk Z, Kalayci CC Tags: Complement Ther Med Source Type: research

Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men – an explorative randomized placebo - controlled double blind study
Conclusion: The results show that Ze 185 significantly attenuated the subjective emotional stress response during an acute stress situation, without affecting biological stress responses. Given that a circumscribed biological stress response is to be considered as an adaptive mechanism, Ze 185 reduces self-reported anxiety response to stress without affecting assumingly adaptive biological stress responses. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - December 12, 2017 Category: Drugs & Pharmacology Source Type: research